SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h4u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 2h4u THIOESTERASE
SUPERFAMILY MEMBER 2
(Homo
sapiens) 		4 / 5 GLY A 139
LEU A 138
THR A 112
VAL A  82
 None
 1.11A 1ekjF-2h4uA:
undetectable
1ekjG-2h4uA:
undetectable		 1ekjF-2h4uA:
18.34
1ekjG-2h4uA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2h4u THIOESTERASE
SUPERFAMILY MEMBER 2
(Homo
sapiens) 		4 / 8 ASN A  20
PHE A  21
ASN A  66
ASP A  65
 None
 1.30A 1p6kB-2h4uA:
undetectable		 1p6kB-2h4uA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 2h4u THIOESTERASE
SUPERFAMILY MEMBER 2
(Homo
sapiens) 		4 / 8 LYS A 136
THR A 116
ALA A 114
VAL A 106
 None
 0.87A 1sn5C-2h4uA:
undetectable		 1sn5C-2h4uA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 2h4u THIOESTERASE
SUPERFAMILY MEMBER 2
(Homo
sapiens) 		4 / 7 LYS A 136
THR A 116
ALA A 114
VAL A 106
 None
 0.77A 1tyrB-2h4uA:
undetectable		 1tyrB-2h4uA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2h4u THIOESTERASE
SUPERFAMILY MEMBER 2
(Homo
sapiens) 		3 / 3 GLU A  98
GLU A  45
LEU A  59
 None
 0.65A 1v8bA-2h4uA:
undetectable		 1v8bA-2h4uA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2h4u THIOESTERASE
SUPERFAMILY MEMBER 2
(Homo
sapiens) 		3 / 3 GLU A  98
GLU A  45
LEU A  59
 None
 0.71A 1v8bB-2h4uA:
undetectable		 1v8bB-2h4uA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2h4u THIOESTERASE
SUPERFAMILY MEMBER 2
(Homo
sapiens) 		4 / 8 ASN A  20
PHE A  21
ASN A  66
ASP A  65
 None
 1.27A 1zzuA-2h4uA:
undetectable		 1zzuA-2h4uA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2h4u THIOESTERASE
SUPERFAMILY MEMBER 2
(Homo
sapiens) 		4 / 8 SER A 117
ARG A 133
ASN A  87
ASP A 119
 None
 1.11A 1zzuA-2h4uA:
undetectable		 1zzuA-2h4uA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2h4u THIOESTERASE
SUPERFAMILY MEMBER 2
(Homo
sapiens) 		4 / 8 ASN A  20
PHE A  21
ASN A  66
ASP A  65
 None
 1.29A 1zzuB-2h4uA:
undetectable		 1zzuB-2h4uA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 2h4u THIOESTERASE
SUPERFAMILY MEMBER 2
(Homo
sapiens) 		4 / 8 ASN A  20
PHE A  21
ASN A  66
ASP A  65
 None
 1.27A 3n66B-2h4uA:
undetectable		 3n66B-2h4uA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 2h4u THIOESTERASE
SUPERFAMILY MEMBER 2
(Homo
sapiens) 		4 / 8 LYS A 136
THR A 116
ALA A 114
VAL A 106
 None
 0.84A 4iizB-2h4uA:
undetectable		 4iizB-2h4uA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 2h4u THIOESTERASE
SUPERFAMILY MEMBER 2
(Homo
sapiens) 		4 / 7 LYS A 136
THR A 116
ALA A 114
VAL A 106
 None
 0.75A 4ik7A-2h4uA:
undetectable		 4ik7A-2h4uA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 2h4u THIOESTERASE
SUPERFAMILY MEMBER 2
(Homo
sapiens) 		5 / 12 ILE A 102
ILE A  88
LEU A  63
LEU A  55
LEU A  59
 None
 1.23A 5tiwA-2h4uA:
undetectable		 5tiwA-2h4uA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 2h4u THIOESTERASE
SUPERFAMILY MEMBER 2
(Homo
sapiens) 		3 / 3 VAL A 106
ALA A  71
GLN A 109
 None
 0.71A 6gb9A-2h4uA:
undetectable		 6gb9A-2h4uA:
17.14