SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h57'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2h57 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
6
(Homo
sapiens) 		3 / 3 LYS A  85
ILE A  90
THR A  66
 None
 0.85A 1rx3A-2h57A:
1.8		 1rx3A-2h57A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 2h57 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
6
(Homo
sapiens) 		4 / 6 THR A  31
GLU A  56
PHE A  53
ILE A  51
 MG  A 202 ( 3.0A)
None
None
None
 1.44A 2w98B-2h57A:
3.3		 2w98B-2h57A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 2h57 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
6
(Homo
sapiens) 		4 / 8 GLY A 167
ILE A  34
CYH A  22
PHE A  92
 None
 1.01A 3ko0B-2h57A:
0.0
3ko0J-2h57A:
undetectable		 3ko0B-2h57A:
18.65
3ko0J-2h57A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC201_1
(PROTEIN S100-A4)		 2h57 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
6
(Homo
sapiens) 		5 / 9 PHE A 128
GLY A 167
ILE A  34
CYH A  22
PHE A  92
 None
 1.44A 3ko0A-2h57A:
undetectable
3ko0C-2h57A:
undetectable		 3ko0A-2h57A:
18.65
3ko0C-2h57A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI201_1
(PROTEIN S100-A4)		 2h57 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
6
(Homo
sapiens) 		5 / 9 PHE A 128
GLY A 167
ILE A  34
CYH A  22
PHE A  92
 None
 1.44A 3ko0H-2h57A:
undetectable
3ko0I-2h57A:
0.0		 3ko0H-2h57A:
18.65
3ko0I-2h57A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 2h57 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
6
(Homo
sapiens) 		4 / 8 GLY A 167
ILE A  34
CYH A  22
PHE A  92
 None
 1.02A 3ko0K-2h57A:
0.0
3ko0S-2h57A:
0.0		 3ko0K-2h57A:
18.65
3ko0S-2h57A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN201_1
(PROTEIN S100-A4)		 2h57 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
6
(Homo
sapiens) 		5 / 10 GLY A 173
GLY A 167
ILE A  34
CYH A  22
PHE A  92
 None
 1.16A 3ko0L-2h57A:
undetectable
3ko0N-2h57A:
undetectable		 3ko0L-2h57A:
18.65
3ko0N-2h57A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN201_1
(PROTEIN S100-A4)		 2h57 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
6
(Homo
sapiens) 		5 / 10 PHE A 128
GLY A 167
ILE A  34
CYH A  22
PHE A  92
 None
 1.43A 3ko0L-2h57A:
undetectable
3ko0N-2h57A:
undetectable		 3ko0L-2h57A:
18.65
3ko0N-2h57A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 2h57 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
6
(Homo
sapiens) 		5 / 10 GLY A 167
ILE A  34
CYH A  22
PHE A  92
PHE A 128
 None
 1.46A 3ko0R-2h57A:
undetectable
3ko0T-2h57A:
undetectable		 3ko0R-2h57A:
18.65
3ko0T-2h57A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 2h57 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
6
(Homo
sapiens) 		3 / 3 LYS A  85
ILE A  90
THR A  66
 None
 0.88A 4gh8A-2h57A:
1.7		 4gh8A-2h57A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 2h57 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
6
(Homo
sapiens) 		4 / 8 LEU A 126
ILE A  94
PHE A 128
GLY A 169
 None
 0.82A 4hb6A-2h57A:
undetectable		 4hb6A-2h57A:
13.16