SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h5g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE
(Homo
sapiens) 		5 / 12 LEU A 487
LEU A 433
LEU A 392
ILE A 515
LEU A 428
 None
 1.04A 2ouzA-2h5gA:
undetectable		 2ouzA-2h5gA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB926_0
(FERROCHELATASE)		 2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE
(Homo
sapiens) 		5 / 10 LEU A 757
ILE A 556
ARG A 558
SER A 446
GLY A 730
 None
None
SO4  A 301 (-3.8A)
None
None
 1.10A 2qd4B-2h5gA:
3.2		 2qd4B-2h5gA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE
(Homo
sapiens) 		5 / 12 PRO A 575
GLY A 498
SER A 497
LEU A 757
LEU A 377
 None
 1.12A 3e23A-2h5gA:
undetectable		 3e23A-2h5gA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE
(Homo
sapiens) 		5 / 11 GLY A 669
GLU A 616
LEU A 673
LEU A 671
LEU A 615
 None
 1.04A 3ndvA-2h5gA:
undetectable
3ndvB-2h5gA:
undetectable		 3ndvA-2h5gA:
23.08
3ndvB-2h5gA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE
(Homo
sapiens) 		5 / 11 LEU A 615
GLY A 669
GLU A 616
LEU A 673
LEU A 671
 None
 0.99A 3ndvA-2h5gA:
undetectable
3ndvB-2h5gA:
undetectable		 3ndvA-2h5gA:
23.08
3ndvB-2h5gA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE
(Homo
sapiens) 		5 / 11 GLY A 669
GLU A 616
LEU A 673
LEU A 671
LEU A 615
 None
 1.01A 3ndvC-2h5gA:
undetectable
3ndvD-2h5gA:
undetectable		 3ndvC-2h5gA:
23.08
3ndvD-2h5gA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE
(Homo
sapiens) 		5 / 11 LEU A 615
GLY A 669
GLU A 616
LEU A 673
LEU A 671
 None
 1.02A 3ndvC-2h5gA:
undetectable
3ndvD-2h5gA:
undetectable		 3ndvC-2h5gA:
23.08
3ndvD-2h5gA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE
(Homo
sapiens) 		4 / 7 LEU A 757
LEU A 554
PRO A 557
ILE A 556
 None
 0.94A 3s56B-2h5gA:
undetectable		 3s56B-2h5gA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE
(Homo
sapiens) 		4 / 5 HIS A 585
GLY A 692
TYR A 691
GLU A 676
 None
 1.34A 4ae1B-2h5gA:
undetectable		 4ae1B-2h5gA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE
(Homo
sapiens) 		4 / 6 ILE A 552
VAL A 478
CYH A 486
ILE A 479
 None
 0.93A 4asdA-2h5gA:
undetectable		 4asdA-2h5gA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE
(Homo
sapiens) 		5 / 12 LEU A 501
VAL A 478
ALA A 491
LEU A 754
LEU A 757
 None
 0.91A 4i1rA-2h5gA:
undetectable		 4i1rA-2h5gA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE
(Homo
sapiens) 		4 / 8 SER A 447
LEU A 754
ARG A 453
ARG A 792
 None
 1.22A 4ijiF-2h5gA:
undetectable		 4ijiF-2h5gA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE
(Homo
sapiens) 		4 / 8 ILE A 688
LEU A 624
LEU A 618
ILE A 633
 None
 0.78A 4r38A-2h5gA:
undetectable		 4r38A-2h5gA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE
(Homo
sapiens) 		4 / 8 ILE A 688
LEU A 624
LEU A 618
ILE A 633
 None
 0.82A 4r38D-2h5gA:
undetectable		 4r38D-2h5gA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE
(Homo
sapiens) 		5 / 10 ALA A 492
LEU A 392
ALA A 393
LEU A 524
ALA A 523
 None
 1.07A 4zbrA-2h5gA:
undetectable		 4zbrA-2h5gA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE
(Homo
sapiens) 		3 / 3 PRO A 751
ILE A 495
SER A 728
 None
 0.79A 5fsaA-2h5gA:
undetectable		 5fsaA-2h5gA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE
(Homo
sapiens) 		5 / 12 ALA A 737
GLY A 730
LEU A 754
ALA A 492
GLY A 439
 None
 0.90A 5jglB-2h5gA:
2.7		 5jglB-2h5gA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_A_ASCA1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE
(Homo
sapiens) 		4 / 6 HIS A 713
VAL A 714
GLN A 682
HIS A 689
 None
 1.27A 5kkzA-2h5gA:
undetectable
5kkzG-2h5gA:
undetectable		 5kkzA-2h5gA:
21.83
5kkzG-2h5gA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE
(Homo
sapiens) 		4 / 7 HIS A 689
HIS A 713
VAL A 714
GLN A 682
 None
 1.31A 5kkzM-2h5gA:
undetectable
5kkzO-2h5gA:
undetectable		 5kkzM-2h5gA:
17.52
5kkzO-2h5gA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE
(Homo
sapiens) 		3 / 3 LEU A 487
THR A 538
ASN A 537
 None
 0.67A 6baaE-2h5gA:
2.1		 6baaE-2h5gA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE
(Homo
sapiens) 		3 / 3 LEU A 487
THR A 538
ASN A 537
 None
 0.67A 6baaF-2h5gA:
2.1		 6baaF-2h5gA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE
(Homo
sapiens) 		3 / 3 LEU A 487
THR A 538
ASN A 537
 None
 0.67A 6baaG-2h5gA:
2.0		 6baaG-2h5gA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE
(Homo
sapiens) 		3 / 3 LEU A 487
THR A 538
ASN A 537
 None
 0.67A 6baaH-2h5gA:
2.0		 6baaH-2h5gA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE
(Homo
sapiens) 		5 / 12 LEU A 554
ILE A 473
GLY A 474
ILE A 556
VAL A 490
 None
 1.01A 6emuA-2h5gA:
4.8		 6emuA-2h5gA:
18.24