SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h5j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2h5j CASPASE-3, P17
SUBUNIT
(Homo
sapiens) 		3 / 3 ILE A  96
LEU A  99
VAL A 103
 None
 0.26A 1mz9B-2h5jA:
undetectable		 1mz9B-2h5jA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 2h5j CASPASE-3, P17
SUBUNIT
(Homo
sapiens) 		5 / 12 ILE A  50
ILE A  96
ILE A 139
LEU A 136
ARG A  64
 None
 1.07A 1qhyA-2h5jA:
undetectable		 1qhyA-2h5jA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2h5j CASPASE-3, P17
SUBUNIT
(Homo
sapiens) 		3 / 3 THR A  92
ASP A 102
SER A 104
 None
 0.76A 2nxeA-2h5jA:
3.4		 2nxeA-2h5jA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2h5j CASPASE-3, P17
SUBUNIT
(Homo
sapiens) 		3 / 3 THR A  92
ASP A 102
SER A 104
 None
 0.73A 2nxeB-2h5jA:
3.6		 2nxeB-2h5jA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 2h5j CASPASE-3, P17
SUBUNIT
(Homo
sapiens) 		4 / 4 GLU A 123
GLY A 165
THR A 166
GLU A 167
 None
 0.75A 3e9xA-2h5jA:
undetectable		 3e9xA-2h5jA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 2h5j CASPASE-3, P17
SUBUNIT
(Homo
sapiens) 		3 / 3 LYS A 110
ARG A 111
HIS A 108
 None
 1.01A 4zbrA-2h5jA:
undetectable		 4zbrA-2h5jA:
14.00