SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h5r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 2h5r MSTRAWBERRY
(Discosoma
sp.) 		5 / 10 ALA A  44
LEU A 213
LEU A  61
GLU A  28
MET A  18
 None
CRO  A  66 ( 4.3A)
None
None
None
 1.31A 1a29A-2h5rA:
undetectable		 1a29A-2h5rA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 2h5r MSTRAWBERRY
(Discosoma
sp.) 		5 / 11 LEU A  61
VAL A  22
VAL A 105
GLY A 126
LEU A  54
 None
 1.36A 1fkpA-2h5rA:
undetectable		 1fkpA-2h5rA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 2h5r MSTRAWBERRY
(Discosoma
sp.) 		3 / 3 PHE A  56
LEU A  61
LEU A 124
 None
 0.62A 1mx1E-2h5rA:
undetectable		 1mx1E-2h5rA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2h5r MSTRAWBERRY
(Discosoma
sp.) 		3 / 3 LEU A  54
PHE A  27
ARG A  95
 None
None
CRO  A  66 ( 2.9A)
 0.80A 1xdkB-2h5rA:
undetectable		 1xdkB-2h5rA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 2h5r MSTRAWBERRY
(Discosoma
sp.) 		4 / 4 LEU A 189
LEU A  85
SER A  86
LEU A  83
 None
 1.03A 1ya3A-2h5rA:
undetectable		 1ya3A-2h5rA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 2h5r MSTRAWBERRY
(Discosoma
sp.) 		4 / 6 LEU A  83
GLN A 188
PRO A 190
TYR A  82
 None
 1.35A 3vkxA-2h5rA:
undetectable		 3vkxA-2h5rA:
23.84