SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h5x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2h5x HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVA
(Mycobacterium
tuberculosis) 		3 / 3 THR A  73
LEU A  74
VAL A  80
 None
None
GOL  A 501 ( 4.8A)
 0.68A 1mz9E-2h5xA:
undetectable		 1mz9E-2h5xA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 2h5x HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVA
(Mycobacterium
tuberculosis) 		5 / 12 THR A  73
LEU A  97
LEU A  89
ILE A 115
LEU A 101
 None
 1.04A 2ouzA-2h5xA:
undetectable		 2ouzA-2h5xA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2h5x HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVA
(Mycobacterium
tuberculosis) 		3 / 3 GLY A 119
GLY A 114
GLY A 116
 None
 0.37A 3bogC-2h5xA:
undetectable		 3bogC-2h5xA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAI_B_AZMB263_1
(CARBONIC ANHYDRASE 9)		 2h5x HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVA
(Mycobacterium
tuberculosis) 		5 / 11 VAL A  28
VAL A   9
LEU A  35
THR A  31
THR A  34
 None
 1.34A 3iaiB-2h5xA:
undetectable		 3iaiB-2h5xA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 2h5x HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVA
(Mycobacterium
tuberculosis) 		3 / 3 ASN A 105
ALA A 107
ARG A 111
 None
 0.43A 5cvtB-2h5xA:
undetectable		 5cvtB-2h5xA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 2h5x HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVA
(Mycobacterium
tuberculosis) 		5 / 11 ALA A  88
ALA A  85
LEU A  74
LEU A 101
VAL A  77
 None
 1.13A 5eb5A-2h5xA:
undetectable		 5eb5A-2h5xA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 2h5x HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVA
(Mycobacterium
tuberculosis) 		5 / 11 ALA A  88
ALA A  85
VAL A  80
LEU A  74
VAL A  77
 None
None
GOL  A 501 ( 4.8A)
None
None
 1.30A 5eb5A-2h5xA:
undetectable		 5eb5A-2h5xA:
18.31