SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h63'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2h63 BILIVERDIN REDUCTASE
A
(Homo
sapiens) 		4 / 5 SER A 211
THR A 207
PHE A 180
GLY A 148
 None
 1.10A 1icrA-2h63A:
undetectable
1icrB-2h63A:
undetectable		 1icrA-2h63A:
22.22
1icrB-2h63A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2h63 BILIVERDIN REDUCTASE
A
(Homo
sapiens) 		4 / 5 GLY A 148
SER A 211
THR A 207
PHE A 180
 None
 1.05A 1icrA-2h63A:
undetectable
1icrB-2h63A:
undetectable		 1icrA-2h63A:
22.22
1icrB-2h63A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2h63 BILIVERDIN REDUCTASE
A
(Homo
sapiens) 		4 / 6 SER A 211
THR A 207
PHE A 180
GLY A 148
 None
 1.13A 1icuA-2h63A:
undetectable
1icuB-2h63A:
undetectable		 1icuA-2h63A:
22.22
1icuB-2h63A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2h63 BILIVERDIN REDUCTASE
A
(Homo
sapiens) 		4 / 6 GLY A 148
SER A 211
THR A 207
PHE A 180
 None
 1.13A 1icuA-2h63A:
undetectable
1icuB-2h63A:
undetectable		 1icuA-2h63A:
22.22
1icuB-2h63A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2h63 BILIVERDIN REDUCTASE
A
(Homo
sapiens) 		4 / 5 GLY A 148
SER A 211
THR A 207
PHE A 180
 None
 1.24A 1icuC-2h63A:
undetectable
1icuD-2h63A:
undetectable		 1icuC-2h63A:
22.22
1icuD-2h63A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2h63 BILIVERDIN REDUCTASE
A
(Homo
sapiens) 		4 / 5 GLY A 148
SER A 211
THR A 207
PHE A 180
 None
 1.14A 1icvA-2h63A:
undetectable
1icvB-2h63A:
undetectable		 1icvA-2h63A:
22.22
1icvB-2h63A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2h63 BILIVERDIN REDUCTASE
A
(Homo
sapiens) 		4 / 5 SER A 211
THR A 207
PHE A 180
GLY A 148
 None
 1.13A 1icvC-2h63A:
undetectable
1icvD-2h63A:
undetectable		 1icvC-2h63A:
22.22
1icvD-2h63A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2h63 BILIVERDIN REDUCTASE
A
(Homo
sapiens) 		4 / 5 GLY A 148
SER A 211
THR A 207
PHE A 180
 None
 1.16A 1icvC-2h63A:
undetectable
1icvD-2h63A:
undetectable		 1icvC-2h63A:
22.22
1icvD-2h63A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2h63 BILIVERDIN REDUCTASE
A
(Homo
sapiens) 		4 / 6 SER A 211
THR A 207
PHE A 180
GLY A 148
 None
 1.04A 1kqbA-2h63A:
undetectable
1kqbB-2h63A:
undetectable		 1kqbA-2h63A:
21.45
1kqbB-2h63A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2h63 BILIVERDIN REDUCTASE
A
(Homo
sapiens) 		4 / 5 GLY A 148
SER A 211
THR A 207
PHE A 180
 None
 1.10A 1kqbA-2h63A:
undetectable
1kqbB-2h63A:
undetectable		 1kqbA-2h63A:
21.45
1kqbB-2h63A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2h63 BILIVERDIN REDUCTASE
A
(Homo
sapiens) 		4 / 6 SER A 211
THR A 207
PHE A 180
GLY A 148
 None
 1.11A 1kqbC-2h63A:
undetectable
1kqbD-2h63A:
undetectable		 1kqbC-2h63A:
21.45
1kqbD-2h63A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2h63 BILIVERDIN REDUCTASE
A
(Homo
sapiens) 		4 / 6 GLY A 148
SER A 211
THR A 207
PHE A 180
 None
 1.10A 1kqbC-2h63A:
undetectable
1kqbD-2h63A:
undetectable		 1kqbC-2h63A:
21.45
1kqbD-2h63A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 2h63 BILIVERDIN REDUCTASE
A
(Homo
sapiens) 		4 / 7 TYR A  98
GLU A 124
MET A 130
ILE A 250
 NAP  A 501 (-3.6A)
NAP  A 501 ( 3.9A)
None
None
 1.02A 1tuvA-2h63A:
undetectable		 1tuvA-2h63A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2h63 BILIVERDIN REDUCTASE
A
(Homo
sapiens) 		5 / 11 TYR A  98
ILE A 250
LEU A  95
ILE A 257
PHE A 251
 NAP  A 501 (-3.6A)
None
None
None
None
 1.22A 2h42A-2h63A:
undetectable		 2h42A-2h63A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 2h63 BILIVERDIN REDUCTASE
A
(Homo
sapiens) 		5 / 12 VAL A  70
PHE A  87
ILE A  73
LEU A 121
ALA A 107
 None
 1.48A 5fctB-2h63A:
undetectable		 5fctB-2h63A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2h63 BILIVERDIN REDUCTASE
A
(Homo
sapiens) 		5 / 12 VAL A 126
ASP A 254
LEU A 157
ARG A  23
GLY A  20
 None
 1.11A 5m50E-2h63A:
2.3		 5m50E-2h63A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 2h63 BILIVERDIN REDUCTASE
A
(Homo
sapiens) 		5 / 12 LEU A  95
LEU A  48
GLY A  10
LEU A  27
ARG A  23
 None
 1.26A 6a7pA-2h63A:
undetectable		 6a7pA-2h63A:
20.83