SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h6c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 2h6c CHLOROPHENOL
REDUCTION GENE K
(Desulfitobacteri
um
dehalogenans) 		3 / 3 GLU A 100
ALA A  38
SER A  41
 None
 0.70A 1errB-2h6cA:
undetectable		 1errB-2h6cA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 2h6c CHLOROPHENOL
REDUCTION GENE K
(Desulfitobacteri
um
dehalogenans) 		5 / 9 THR A 104
LEU A  56
ALA A  96
TYR A  95
GLU A  72
 None
 1.42A 2azqA-2h6cA:
undetectable		 2azqA-2h6cA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2h6c CHLOROPHENOL
REDUCTION GENE K
(Desulfitobacteri
um
dehalogenans) 		5 / 11 GLU A 159
LEU A 160
SER A 162
LEU A 222
LEU A 156
 None
 1.32A 3ndvA-2h6cA:
undetectable
3ndvB-2h6cA:
undetectable		 3ndvA-2h6cA:
19.61
3ndvB-2h6cA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2h6c CHLOROPHENOL
REDUCTION GENE K
(Desulfitobacteri
um
dehalogenans) 		5 / 11 LEU A 156
GLU A 159
LEU A 160
SER A 162
LEU A 222
 None
 1.31A 3ndvA-2h6cA:
undetectable
3ndvB-2h6cA:
undetectable		 3ndvA-2h6cA:
19.61
3ndvB-2h6cA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2h6c CHLOROPHENOL
REDUCTION GENE K
(Desulfitobacteri
um
dehalogenans) 		5 / 11 GLU A 159
LEU A 160
SER A 162
LEU A 222
LEU A 156
 None
 1.29A 3ndvC-2h6cA:
undetectable
3ndvD-2h6cA:
undetectable		 3ndvC-2h6cA:
19.61
3ndvD-2h6cA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2h6c CHLOROPHENOL
REDUCTION GENE K
(Desulfitobacteri
um
dehalogenans) 		5 / 11 LEU A 156
GLU A 159
LEU A 160
SER A 162
LEU A 222
 None
 1.31A 3ndvC-2h6cA:
undetectable
3ndvD-2h6cA:
undetectable		 3ndvC-2h6cA:
19.61
3ndvD-2h6cA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 2h6c CHLOROPHENOL
REDUCTION GENE K
(Desulfitobacteri
um
dehalogenans) 		5 / 9 PHE A 157
LEU A 198
VAL A 194
LEU A 178
ILE A 183
 None
 1.11A 3tbgD-2h6cA:
undetectable		 3tbgD-2h6cA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2h6c CHLOROPHENOL
REDUCTION GENE K
(Desulfitobacteri
um
dehalogenans) 		4 / 7 LEU A 222
LEU A 219
ILE A 174
MET A 176
 None
 1.03A 3u5jA-2h6cA:
undetectable		 3u5jA-2h6cA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2h6c CHLOROPHENOL
REDUCTION GENE K
(Desulfitobacteri
um
dehalogenans) 		3 / 3 TYR A  76
GLU A  72
TYR A  95
 None
 1.03A 3ug8A-2h6cA:
undetectable		 3ug8A-2h6cA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 2h6c CHLOROPHENOL
REDUCTION GENE K
(Desulfitobacteri
um
dehalogenans) 		4 / 6 LEU A 201
LEU A 198
SER A 195
THR A 193
 None
 1.09A 4d7bB-2h6cA:
undetectable		 4d7bB-2h6cA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 2h6c CHLOROPHENOL
REDUCTION GENE K
(Desulfitobacteri
um
dehalogenans) 		4 / 6 LEU A 201
LEU A 198
SER A 195
THR A 193
 None
 1.07A 5bojA-2h6cA:
1.9		 5bojA-2h6cA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2h6c CHLOROPHENOL
REDUCTION GENE K
(Desulfitobacteri
um
dehalogenans) 		4 / 4 LEU A 112
ARG A 117
ILE A 115
PHE A 116
 None
 1.05A 5kirB-2h6cA:
undetectable		 5kirB-2h6cA:
17.96