SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h6o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 2h6o MAJOR OUTER ENVELOPE
GLYCOPROTEIN GP350
(Human
gammaherpesvirus
4) 		5 / 12 ILE A 230
PHE A 228
PHE A 196
LEU A 179
LEU A 281
 None
 1.19A 1dtlA-2h6oA:
undetectable		 1dtlA-2h6oA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2h6o MAJOR OUTER ENVELOPE
GLYCOPROTEIN GP350
(Human
gammaherpesvirus
4) 		4 / 7 LEU A  63
ALA A  48
VAL A 130
VAL A 128
 None
 0.63A 1epbA-2h6oA:
undetectable		 1epbA-2h6oA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2h6o MAJOR OUTER ENVELOPE
GLYCOPROTEIN GP350
(Human
gammaherpesvirus
4) 		4 / 8 PHE A  52
ARG A 107
THR A 105
LEU A 104
 None
 0.89A 3abkA-2h6oA:
undetectable
3abkJ-2h6oA:
undetectable		 3abkA-2h6oA:
23.02
3abkJ-2h6oA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2h6o MAJOR OUTER ENVELOPE
GLYCOPROTEIN GP350
(Human
gammaherpesvirus
4) 		4 / 8 PHE A  52
ARG A 107
THR A 105
LEU A 104
 None
 0.88A 3abmN-2h6oA:
undetectable
3abmW-2h6oA:
undetectable		 3abmN-2h6oA:
23.02
3abmW-2h6oA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 2h6o MAJOR OUTER ENVELOPE
GLYCOPROTEIN GP350
(Human
gammaherpesvirus
4) 		5 / 12 PHE A  33
VAL A  46
PHE A  26
LEU A 125
ALA A 144
 None
 1.29A 3apxA-2h6oA:
undetectable		 3apxA-2h6oA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2h6o MAJOR OUTER ENVELOPE
GLYCOPROTEIN GP350
(Human
gammaherpesvirus
4) 		5 / 12 TYR A  36
GLY A  66
ASP A 134
VAL A 135
PRO A  70
 None
 1.02A 3dmfA-2h6oA:
undetectable		 3dmfA-2h6oA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2h6o MAJOR OUTER ENVELOPE
GLYCOPROTEIN GP350
(Human
gammaherpesvirus
4) 		3 / 3 ILE A  50
PHE A  26
HIS A 143
 None
 0.74A 3h0aA-2h6oA:
undetectable		 3h0aA-2h6oA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 2h6o MAJOR OUTER ENVELOPE
GLYCOPROTEIN GP350
(Human
gammaherpesvirus
4) 		4 / 7 VAL A 393
TYR A 324
TRP A 352
LYS A 401
 None
None
None
FUC  A1364 ( 4.3A)
 1.20A 3hs4A-2h6oA:
undetectable		 3hs4A-2h6oA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 2h6o MAJOR OUTER ENVELOPE
GLYCOPROTEIN GP350
(Human
gammaherpesvirus
4) 		4 / 8 SER A 286
SER A 197
GLY A 287
PRO A 290
 None
None
None
NAG  A1195 (-4.0A)
 0.97A 3lslA-2h6oA:
undetectable
3lslD-2h6oA:
undetectable		 3lslA-2h6oA:
19.40
3lslD-2h6oA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 2h6o MAJOR OUTER ENVELOPE
GLYCOPROTEIN GP350
(Human
gammaherpesvirus
4) 		4 / 8 PRO A 290
SER A 286
SER A 197
GLY A 287
 NAG  A1195 (-4.0A)
None
None
None
 0.96A 3lslA-2h6oA:
undetectable
3lslD-2h6oA:
undetectable		 3lslA-2h6oA:
19.40
3lslD-2h6oA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP6_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2h6o MAJOR OUTER ENVELOPE
GLYCOPROTEIN GP350
(Human
gammaherpesvirus
4) 		5 / 12 THR A 267
SER A 241
VAL A 181
ILE A 209
MET A 202
 None
 1.35A 3sp6A-2h6oA:
0.0		 3sp6A-2h6oA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 2h6o MAJOR OUTER ENVELOPE
GLYCOPROTEIN GP350
(Human
gammaherpesvirus
4) 		4 / 6 VAL A 181
LEU A 179
ILE A 303
VAL A 283
 None
 0.90A 4a9kA-2h6oA:
undetectable		 4a9kA-2h6oA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 2h6o MAJOR OUTER ENVELOPE
GLYCOPROTEIN GP350
(Human
gammaherpesvirus
4) 		3 / 3 LYS A 110
LYS A 109
PRO A 154
 None
 1.16A 4dv1L-2h6oA:
undetectable		 4dv1L-2h6oA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 2h6o MAJOR OUTER ENVELOPE
GLYCOPROTEIN GP350
(Human
gammaherpesvirus
4) 		4 / 5 GLY A 294
SER A 293
ALA A 292
PHE A 284
 None
 0.87A 4m93B-2h6oA:
6.5
4m93C-2h6oA:
6.5		 4m93B-2h6oA:
20.42
4m93C-2h6oA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2h6o MAJOR OUTER ENVELOPE
GLYCOPROTEIN GP350
(Human
gammaherpesvirus
4) 		4 / 7 PHE A  52
ARG A 107
THR A 105
LEU A 104
 None
 0.79A 5b1bN-2h6oA:
undetectable
5b1bW-2h6oA:
undetectable		 5b1bN-2h6oA:
23.02
5b1bW-2h6oA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2h6o MAJOR OUTER ENVELOPE
GLYCOPROTEIN GP350
(Human
gammaherpesvirus
4) 		4 / 7 PHE A  52
ARG A 107
THR A 105
LEU A 104
 None
 0.93A 5b3sN-2h6oA:
undetectable
5b3sW-2h6oA:
undetectable		 5b3sN-2h6oA:
23.02
5b3sW-2h6oA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 2h6o MAJOR OUTER ENVELOPE
GLYCOPROTEIN GP350
(Human
gammaherpesvirus
4) 		5 / 9 ILE A 115
GLY A  84
LEU A  61
LEU A 111
LEU A  91
 NDG  A1114 ( 4.7A)
None
None
None
None
 1.37A 5fhzB-2h6oA:
undetectable		 5fhzB-2h6oA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 2h6o MAJOR OUTER ENVELOPE
GLYCOPROTEIN GP350
(Human
gammaherpesvirus
4) 		5 / 12 PHE A  65
GLY A  80
ALA A  81
ASP A  64
ILE A  50
 None
None
None
NAG  A1047 (-4.6A)
None
 1.10A 6dwnD-2h6oA:
undetectable		 6dwnD-2h6oA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2h6o MAJOR OUTER ENVELOPE
GLYCOPROTEIN GP350
(Human
gammaherpesvirus
4) 		4 / 5 ARG A 107
MET A 106
THR A 105
LEU A 104
 None
 1.31A 6nknW-2h6oA:
undetectable		 6nknW-2h6oA:
8.98