SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h6r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2h6r TRIOSEPHOSPHATE
ISOMERASE
(Methanocaldococc
us
jannaschii) 		4 / 8 VAL A 202
GLY A 201
VAL A 196
ILE A   3
 None
 0.80A 2a1mB-2h6rA:
undetectable		 2a1mB-2h6rA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2h6r TRIOSEPHOSPHATE
ISOMERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  87
GLU A 138
GLY A 176
ASN A   6
ALA A 193
 None
 1.09A 2bm9C-2h6rA:
undetectable		 2bm9C-2h6rA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2h6r TRIOSEPHOSPHATE
ISOMERASE
(Methanocaldococc
us
jannaschii) 		4 / 7 GLU A 138
GLN A  41
ALA A  22
ILE A  48
 None
 0.79A 2xkwA-2h6rA:
undetectable		 2xkwA-2h6rA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 2h6r TRIOSEPHOSPHATE
ISOMERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 135
VAL A 116
ILE A 115
GLU A 194
PRO A 132
 None
 1.30A 2yzqA-2h6rA:
undetectable		 2yzqA-2h6rA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2h6r TRIOSEPHOSPHATE
ISOMERASE
(Methanocaldococc
us
jannaschii) 		4 / 6 VAL A   4
ILE A 100
ALA A 136
LEU A 174
 None
 0.84A 3kk6B-2h6rA:
undetectable		 3kk6B-2h6rA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 2h6r TRIOSEPHOSPHATE
ISOMERASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ILE A  24
ILE A  21
VAL A  28
ILE A   5
ILE A  36
 None
 1.10A 3p4wB-2h6rA:
undetectable		 3p4wB-2h6rA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 2h6r TRIOSEPHOSPHATE
ISOMERASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A  24
ILE A  21
VAL A  28
ILE A   5
ILE A  36
 None
 1.10A 3p4wD-2h6rA:
undetectable		 3p4wD-2h6rA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 2h6r TRIOSEPHOSPHATE
ISOMERASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A  24
ILE A  21
VAL A  28
ILE A   5
ILE A  36
 None
 1.09A 3p4wE-2h6rA:
undetectable		 3p4wE-2h6rA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 2h6r TRIOSEPHOSPHATE
ISOMERASE
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A 100
ILE A 135
LYS A  84
GLY A  85
 None
 0.82A 4hb6A-2h6rA:
undetectable		 4hb6A-2h6rA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 2h6r TRIOSEPHOSPHATE
ISOMERASE
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A 100
ILE A 135
LYS A  84
GLY A  85
 None
 0.84A 4hb8A-2h6rA:
undetectable		 4hb8A-2h6rA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 2h6r TRIOSEPHOSPHATE
ISOMERASE
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A 100
ILE A 135
LYS A  84
GLY A  85
 None
 0.76A 4hdlA-2h6rA:
undetectable		 4hdlA-2h6rA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2h6r TRIOSEPHOSPHATE
ISOMERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  78
GLN A  59
LEU A  87
ILE A  88
VAL A 103
 None
 1.07A 4k6iA-2h6rA:
undetectable		 4k6iA-2h6rA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2h6r TRIOSEPHOSPHATE
ISOMERASE
(Methanocaldococc
us
jannaschii) 		4 / 8 ALA A 126
ASP A  99
ILE A 100
ILE A  88
 None
 0.90A 4kttD-2h6rA:
undetectable		 4kttD-2h6rA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2h6r TRIOSEPHOSPHATE
ISOMERASE
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A 198
ILE A 179
GLY A 178
LEU A 174
VAL A 196
 None
 0.95A 5twjD-2h6rA:
undetectable		 5twjD-2h6rA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2h6r TRIOSEPHOSPHATE
ISOMERASE
(Methanocaldococc
us
jannaschii) 		4 / 6 SER A 200
TYR A  10
GLU A  92
THR A   9
 None
 1.32A 6djzA-2h6rA:
undetectable		 6djzA-2h6rA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2h6r TRIOSEPHOSPHATE
ISOMERASE
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A 123
GLU A 155
ASN A 119
 None
 0.81A 6nj9K-2h6rA:
undetectable		 6nj9K-2h6rA:
20.85