SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h6t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		5 / 10 GLY A 122
ASP A  32
ILE A  31
ILE A 126
ILE A  99
 None
 1.08A 1sh9B-2h6tA:
5.4		 1sh9B-2h6tA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		5 / 12 THR A  19
GLY A  63
GLN A  25
ILE A  99
PHE A 111
 None
 1.33A 2azxA-2h6tA:
undetectable		 2azxA-2h6tA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		4 / 7 PHE A 279
PHE A 264
ILE A 208
GLY A 260
 None
 0.88A 2v0mC-2h6tA:
undetectable		 2v0mC-2h6tA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		5 / 12 ASP A 218
GLY A 220
ASP A  32
GLY A  34
SER A  36
 None
 0.78A 2v0zC-2h6tA:
34.7		 2v0zC-2h6tA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		7 / 12 VAL A  30
ASP A  32
GLY A  34
SER A  35
TYR A  84
ASP A 218
GLY A 220
 None
 0.47A 2v0zC-2h6tA:
34.7		 2v0zC-2h6tA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		5 / 12 ASP A 218
GLY A 220
ASP A  32
GLY A  34
SER A  36
 None
 0.78A 2v0zO-2h6tA:
34.4		 2v0zO-2h6tA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		5 / 12 VAL A  30
ASP A  32
GLY A  34
ASP A 218
GLY A 220
 None
 0.36A 2v0zO-2h6tA:
34.4		 2v0zO-2h6tA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		4 / 7 TYR A  65
VAL A  40
ILE A  99
ASP A  97
 None
 1.25A 2x45B-2h6tA:
undetectable		 2x45B-2h6tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		4 / 5 LEU A 216
ASP A 218
ILE A 305
GLY A  34
 None
 0.50A 3bufA-2h6tA:
30.8		 3bufA-2h6tA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		5 / 12 ASP A  32
GLY A  34
VAL A  30
LEU A 216
ASP A 218
 None
 1.17A 3d91B-2h6tA:
34.4		 3d91B-2h6tA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		4 / 8 ASP A  32
GLY A  34
ASP A  37
ILE A 123
 None
 0.65A 3el0A-2h6tA:
4.6		 3el0A-2h6tA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_C_SRYC403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		5 / 12 ASN A 309
ASP A 308
SER A 219
SER A  35
ASP A  32
 None
 1.42A 3havC-2h6tA:
undetectable		 3havC-2h6tA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		5 / 12 TYR A 315
LEU A 183
SER A 336
ILE A 170
GLY A 172
 None
 1.09A 3kk6A-2h6tA:
undetectable		 3kk6A-2h6tA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		5 / 12 TYR A 315
LEU A 183
SER A 336
ILE A 170
GLY A 172
 None
 1.11A 3kk6B-2h6tA:
undetectable		 3kk6B-2h6tA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		5 / 12 ARG A 195
TYR A 225
PHE A 298
ILE A 305
LEU A 217
 None
 1.29A 3lcvB-2h6tA:
undetectable		 3lcvB-2h6tA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		7 / 12 ASP A  32
GLY A  34
ASP A 120
ASP A 218
THR A 221
TYR A 225
ILE A 305
 None
 0.79A 3prsA-2h6tA:
35.2		 3prsA-2h6tA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		8 / 12 ASP A  32
GLY A  34
GLY A  85
ASP A  86
ASP A 218
THR A 221
TYR A 225
ILE A 305
 None
 0.48A 3prsA-2h6tA:
35.2		 3prsA-2h6tA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		5 / 12 ASP A 308
GLY A  34
ASP A 120
THR A 221
ILE A 305
 None
 1.11A 3prsA-2h6tA:
35.2		 3prsA-2h6tA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		5 / 12 ASP A  32
GLY A  85
THR A 221
TYR A 225
ILE A 305
 None
 0.44A 3pwwA-2h6tA:
35.1		 3pwwA-2h6tA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		6 / 8 GLY A  34
SER A  35
ILE A  82
TYR A  84
ASP A  86
ASP A 218
 None
 0.51A 3pwwA-2h6tA:
35.1		 3pwwA-2h6tA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		6 / 8 GLY A  34
SER A  35
ILE A  82
TYR A  84
ASP A 218
THR A 222
 None
 0.31A 3pwwA-2h6tA:
35.1		 3pwwA-2h6tA:
27.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		9 / 12 ILE A 123
ASP A  32
GLY A  34
GLY A  85
GLU A 193
ASP A 218
THR A 221
TYR A 225
ILE A 305
 None
 1.14A 3q70A-2h6tA:
50.9		 3q70A-2h6tA:
73.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		5 / 6 SER A  35
ILE A  82
TYR A  84
ASP A 120
THR A 222
 None
 0.68A 3q70A-2h6tA:
50.9		 3q70A-2h6tA:
73.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		9 / 12 ASP A  32
GLY A  34
ILE A  82
GLY A  85
ASP A  86
ASP A 120
ASP A 218
TYR A 225
ILE A 305
 None
 0.42A 3tneA-2h6tA:
47.6		 3tneA-2h6tA:
53.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		9 / 12 ILE A 123
ASP A  32
GLY A  34
GLY A  85
ASP A  86
ASP A 120
ASP A 218
TYR A 225
ILE A 305
 None
 1.26A 3tneA-2h6tA:
47.6		 3tneA-2h6tA:
53.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		5 / 6 SER A  35
TYR A  84
VAL A 119
THR A 221
THR A 222
 None
 0.24A 3tneA-2h6tA:
47.6		 3tneA-2h6tA:
53.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		8 / 12 ASP A  32
GLY A  34
ILE A  82
GLY A  85
ASP A  86
ASP A 120
ASP A 218
ILE A 305
 None
 0.35A 3tneB-2h6tA:
47.8		 3tneB-2h6tA:
53.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		8 / 12 ILE A 123
ASP A  32
GLY A  34
GLY A  85
ASP A  86
ASP A 120
ASP A 218
ILE A 305
 None
 1.25A 3tneB-2h6tA:
47.8		 3tneB-2h6tA:
53.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		7 / 7 SER A  35
TYR A  84
VAL A 119
ILE A 123
THR A 221
THR A 222
TYR A 225
 None
 0.46A 3tneB-2h6tA:
47.8		 3tneB-2h6tA:
53.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		5 / 12 VAL A 274
ALA A 314
LEU A 217
PHE A 266
PHE A 264
 None
 1.19A 4eckA-2h6tA:
undetectable		 4eckA-2h6tA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		5 / 8 ILE A 272
ASP A 308
LEU A 311
GLY A 307
TYR A  14
 None
 1.35A 4iqqD-2h6tA:
undetectable		 4iqqD-2h6tA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		5 / 11 TYR A 318
LEU A 186
VAL A 188
ILE A 196
LEU A 216
 None
 1.40A 4k37B-2h6tA:
undetectable		 4k37B-2h6tA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		4 / 4 ILE A  82
SER A  90
ASP A  32
ASP A 308
 None
 1.29A 4krhB-2h6tA:
undetectable		 4krhB-2h6tA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		5 / 12 VAL A  29
ILE A  18
GLY A 100
VAL A   3
LEU A 144
 None
 0.86A 4y8wA-2h6tA:
undetectable		 4y8wA-2h6tA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		5 / 12 VAL A  29
ILE A  18
GLY A 100
VAL A   3
LEU A 144
 None
 0.87A 4y8wB-2h6tA:
undetectable		 4y8wB-2h6tA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		5 / 12 VAL A  29
ILE A  18
GLY A 100
VAL A   3
LEU A 144
 None
 0.83A 4y8wC-2h6tA:
undetectable		 4y8wC-2h6tA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		5 / 8 ILE A 272
ASP A 308
LEU A 311
GLY A 307
TYR A  14
 None
 1.37A 5nooD-2h6tA:
undetectable		 5nooD-2h6tA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		5 / 9 LEU A 327
ALA A 270
PHE A 266
HIS A 197
ILE A 325
 None
None
None
ZN  A 602 (-3.1A)
None
 1.12A 5om2A-2h6tA:
undetectable
5om2B-2h6tA:
undetectable		 5om2A-2h6tA:
12.94
5om2B-2h6tA:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 2h6t CANDIDAPEPSIN-3
(Candida
albicans) 		4 / 8 LEU A 226
VAL A 234
VAL A 274
VAL A 262
 None
 1.08A 6cp4A-2h6tA:
undetectable		 6cp4A-2h6tA:
23.28