SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h7g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 2h7g DNA TOPOISOMERASE 1
(Variola
virus) 		5 / 9 ILE X 217
VAL X  94
ILE X 102
ILE X 219
ILE X 212
 None
 0.96A 1hshB-2h7gX:
undetectable		 1hshB-2h7gX:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2h7g DNA TOPOISOMERASE 1
(Variola
virus) 		5 / 11 THR X 190
PHE X 200
PHE X 120
PHE X 127
VAL X 176
 None
 1.34A 1q23J-2h7gX:
undetectable		 1q23J-2h7gX:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 2h7g DNA TOPOISOMERASE 1
(Variola
virus) 		3 / 3 PHE X 297
TYR X 225
TYR X  92
 None
 1.03A 1x70B-2h7gX:
undetectable		 1x70B-2h7gX:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 2h7g DNA TOPOISOMERASE 1
(Variola
virus) 		3 / 3 ARG X  86
VAL X 304
THR X 278
 None
 0.71A 2nmzA-2h7gX:
undetectable		 2nmzA-2h7gX:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 2h7g DNA TOPOISOMERASE 1
(Variola
virus) 		3 / 3 ARG X  86
VAL X 304
THR X 278
 None
 0.77A 2nnkA-2h7gX:
undetectable		 2nnkA-2h7gX:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2h7g DNA TOPOISOMERASE 1
(Variola
virus) 		5 / 12 THR X 278
PHE X 297
ASP X 298
ASP X  85
ARG X  84
 None
 1.03A 3iv6D-2h7gX:
undetectable		 3iv6D-2h7gX:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 2h7g DNA TOPOISOMERASE 1
(Variola
virus) 		3 / 3 ARG X  86
VAL X 304
THR X 278
 None
 0.81A 3k4vA-2h7gX:
undetectable		 3k4vA-2h7gX:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 2h7g DNA TOPOISOMERASE 1
(Variola
virus) 		3 / 3 ARG X  86
VAL X 304
THR X 278
 None
 0.81A 3k4vD-2h7gX:
undetectable		 3k4vD-2h7gX:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 2h7g DNA TOPOISOMERASE 1
(Variola
virus) 		3 / 3 ARG X  86
VAL X 304
THR X 278
 None
 0.77A 3nduD-2h7gX:
undetectable		 3nduD-2h7gX:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 2h7g DNA TOPOISOMERASE 1
(Variola
virus) 		3 / 3 ARG X  86
VAL X 304
THR X 278
 None
 0.74A 3pwrA-2h7gX:
undetectable		 3pwrA-2h7gX:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 2h7g DNA TOPOISOMERASE 1
(Variola
virus) 		3 / 3 ARG X  86
VAL X 304
THR X 278
 None
 0.76A 3tl9A-2h7gX:
undetectable		 3tl9A-2h7gX:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2h7g DNA TOPOISOMERASE 1
(Variola
virus) 		4 / 8 SER X 211
ILE X 212
PHE X 120
GLU X 210
 None
 1.27A 4cx7A-2h7gX:
undetectable
4cx7B-2h7gX:
undetectable		 4cx7A-2h7gX:
21.25
4cx7B-2h7gX:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2h7g DNA TOPOISOMERASE 1
(Variola
virus) 		4 / 8 SER X 211
ILE X 212
PHE X 120
GLU X 210
 None
 1.23A 4cx7C-2h7gX:
undetectable
4cx7D-2h7gX:
undetectable		 4cx7C-2h7gX:
21.25
4cx7D-2h7gX:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2h7g DNA TOPOISOMERASE 1
(Variola
virus) 		4 / 8 GLU X  29
GLU X  51
ARG X  56
GLY X  47
 None
 1.04A 4fgzA-2h7gX:
undetectable
4fgzB-2h7gX:
undetectable		 4fgzA-2h7gX:
22.84
4fgzB-2h7gX:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2h7g DNA TOPOISOMERASE 1
(Variola
virus) 		3 / 3 VAL X 239
SER X 293
TRP X 236
 None
 1.05A 5jwaA-2h7gX:
undetectable		 5jwaA-2h7gX:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 2h7g DNA TOPOISOMERASE 1
(Variola
virus) 		5 / 12 MET X 121
ILE X  98
LEU X 117
PHE X 215
SER X 211
 None
 1.25A 5tiwB-2h7gX:
undetectable		 5tiwB-2h7gX:
21.78