SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h84'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2h84 STEELY1
(Dictyostelium
discoideum) 		5 / 12 PRO A2869
GLY A2982
PHE A3112
VAL A3110
MET A3114
 None
 1.28A 1ffyA-2h84A:
undetectable		 1ffyA-2h84A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 2h84 STEELY1
(Dictyostelium
discoideum) 		5 / 11 PHE A2979
THR A2899
VAL A2868
LEU A2871
ALA A2872
 None
 0.88A 1jinA-2h84A:
undetectable		 1jinA-2h84A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2h84 STEELY1
(Dictyostelium
discoideum) 		4 / 7 LEU A2999
ARG A3118
ASP A2882
GLY A2793
 None
 0.87A 1n13D-2h84A:
0.5
1n13E-2h84A:
undetectable		 1n13D-2h84A:
15.63
1n13E-2h84A:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2h84 STEELY1
(Dictyostelium
discoideum) 		4 / 8 PRO A2797
THR A3072
PHE A3112
ASP A2981
 None
 1.22A 1p7lC-2h84A:
undetectable		 1p7lC-2h84A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2h84 STEELY1
(Dictyostelium
discoideum) 		4 / 8 PRO A2797
THR A3072
PHE A3112
ASP A2981
 None
 1.21A 1p7lD-2h84A:
undetectable		 1p7lD-2h84A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 2h84 STEELY1
(Dictyostelium
discoideum) 		5 / 12 ILE A2827
ILE A3081
ILE A3077
VAL A2974
ILE A2978
 None
 1.25A 1r5lA-2h84A:
undetectable		 1r5lA-2h84A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2h84 STEELY1
(Dictyostelium
discoideum) 		4 / 8 PRO A2797
THR A3072
PHE A3112
ASP A2981
 None
 1.22A 1rg9D-2h84A:
undetectable		 1rg9D-2h84A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2h84 STEELY1
(Dictyostelium
discoideum) 		4 / 8 SER A2977
LEU A3028
PHE A3132
LEU A3078
 None
 1.02A 1wrlC-2h84A:
undetectable
1wrlD-2h84A:
undetectable		 1wrlC-2h84A:
13.64
1wrlD-2h84A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 2h84 STEELY1
(Dictyostelium
discoideum) 		4 / 4 LEU A2910
SER A2983
LEU A2880
LEU A2953
 None
 1.18A 1yajA-2h84A:
undetectable		 1yajA-2h84A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 2h84 STEELY1
(Dictyostelium
discoideum) 		4 / 7 LEU A2962
SER A2961
TYR A2842
VAL A2839
 None
 1.08A 2uz2A-2h84A:
undetectable		 2uz2A-2h84A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2h84 STEELY1
(Dictyostelium
discoideum) 		5 / 12 GLY A3133
CYH A2930
ILE A2978
LEU A3028
LEU A3030
 None
P6G  A1000 (-3.4A)
None
None
P6G  A1000 ( 4.4A)
 1.36A 3cs8A-2h84A:
undetectable		 3cs8A-2h84A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2h84 STEELY1
(Dictyostelium
discoideum) 		4 / 4 LEU A2934
MET A3003
ILE A3087
ASP A3047
 None
 1.50A 3hecA-2h84A:
undetectable		 3hecA-2h84A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 2h84 STEELY1
(Dictyostelium
discoideum) 		5 / 12 GLY A2970
GLY A2969
ILE A2810
SER A2965
SER A2976
 P6G  A1000 (-3.5A)
P6G  A1000 (-3.2A)
None
None
None
 0.98A 3nk7B-2h84A:
undetectable		 3nk7B-2h84A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 2h84 STEELY1
(Dictyostelium
discoideum) 		4 / 6 VAL A2839
ASP A2981
ALA A3108
PHE A3112
 None
 1.14A 4nedA-2h84A:
undetectable		 4nedA-2h84A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2h84 STEELY1
(Dictyostelium
discoideum) 		4 / 8 THR A3057
VAL A3046
LEU A3049
ILE A3128
 None
 0.88A 4r38D-2h84A:
undetectable		 4r38D-2h84A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2h84 STEELY1
(Dictyostelium
discoideum) 		4 / 8 PRO A2797
THR A3072
PHE A3112
ASP A2981
 None
 1.17A 5t8sB-2h84A:
undetectable		 5t8sB-2h84A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 2h84 STEELY1
(Dictyostelium
discoideum) 		4 / 5 ASN A3094
TYR A3000
LEU A2937
SER A3127
 None
 1.27A 6a7pA-2h84A:
undetectable		 6a7pA-2h84A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		 2h84 STEELY1
(Dictyostelium
discoideum) 		4 / 4 LEU A3030
ASP A2971
GLN A2972
VAL A2896
 P6G  A1000 ( 4.4A)
P6G  A1000 (-3.3A)
None
None
 1.43A 6bzoF-2h84A:
undetectable		 6bzoF-2h84A:
21.76