SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h88'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		4 / 5 THR A 230
GLU A 521
THR A 517
LEU A  50
 None
None
None
FAD  A1001 (-3.8A)
 1.21A 1d4fC-2h88A:
3.7		 1d4fC-2h88A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		4 / 6 HIS A 202
ILE A 201
ALA A 445
VAL A 450
 None
 1.04A 1hk1A-2h88A:
2.0		 1hk1A-2h88A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		5 / 9 LEU A  90
ASP A 246
ILE A 602
THR A  83
ILE A  96
 None
 1.42A 1hzeA-2h88A:
0.0
1hzeB-2h88A:
0.0		 1hzeA-2h88A:
9.50
1hzeB-2h88A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		5 / 9 THR A  83
ILE A  96
LEU A  90
ASP A 246
ILE A 602
 None
 1.41A 1hzeA-2h88A:
0.0
1hzeB-2h88A:
0.0		 1hzeA-2h88A:
9.50
1hzeB-2h88A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		5 / 10 GLY A 231
LEU A 247
GLN A 534
THR A 213
GLY A 233
 None
None
None
FAD  A1001 (-4.3A)
None
 1.50A 1kvlA-2h88A:
undetectable		 1kvlA-2h88A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		4 / 8 TYR A 287
ILE A 306
GLU A 307
ARG A 312
 None
 0.65A 1mrjA-2h88A:
undetectable		 1mrjA-2h88A:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_B_CHDB4085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE II
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		5 / 11 GLU A 436
THR A 431
ARG A 205
ARG A 189
GLY A 391
 None
 1.48A 1v54A-2h88A:
1.8
1v54B-2h88A:
0.0
1v54T-2h88A:
0.0		 1v54A-2h88A:
22.47
1v54B-2h88A:
17.01
1v54T-2h88A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		4 / 8 ASP A 298
GLY A 131
PHE A 130
THR A 265
 None
None
None
TEO  A1002 (-3.7A)
 0.99A 2aouA-2h88A:
undetectable		 2aouA-2h88A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		4 / 8 MET A 367
ASP A 246
SER A 402
TYR A 365
 None
None
None
FAD  A1001 ( 4.2A)
 1.38A 2bteD-2h88A:
undetectable		 2bteD-2h88A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_B_CHDB1086_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		5 / 10 GLU A 436
THR A 431
ARG A 205
ARG A 189
GLY A 391
 None
 1.49A 2dyrA-2h88A:
0.0
2dyrB-2h88A:
0.0
2dyrT-2h88A:
0.0		 2dyrA-2h88A:
22.47
2dyrB-2h88A:
17.01
2dyrT-2h88A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		4 / 7 LEU A 456
LEU A 453
ILE A 192
ARG A 203
 None
 0.66A 2hc4A-2h88A:
undetectable		 2hc4A-2h88A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		5 / 12 ALA A 106
ALA A  33
GLY A 396
GLY A  28
TYR A 374
 None
None
FAD  A1001 (-3.6A)
FAD  A1001 (-4.1A)
None
 1.04A 2igtA-2h88A:
undetectable		 2igtA-2h88A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		5 / 12 ALA A 106
ALA A  33
GLY A 396
GLY A  28
TYR A 374
 None
None
FAD  A1001 (-3.6A)
FAD  A1001 (-4.1A)
None
 1.06A 2igtB-2h88A:
2.7		 2igtB-2h88A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		5 / 12 ILE A 264
HIS A 253
PHE A 130
GLY A 131
MET A 367
 None
TEO  A1002 (-4.0A)
None
None
None
 1.42A 2nyrB-2h88A:
2.8		 2nyrB-2h88A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6U_A_BEZA501_0
(NIKD PROTEIN)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		4 / 7 ARG A 546
GLU A 544
PHE A 249
TRP A 579
 None
 1.34A 2q6uA-2h88A:
11.5		 2q6uA-2h88A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		3 / 3 ARG A 189
GLY A 190
SER A 449
 None
 0.63A 2xctB-2h88A:
undetectable		 2xctB-2h88A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		4 / 8 GLY A 215
ASN A 366
SER A 229
THR A 224
 None
None
FAD  A1001 ( 4.9A)
FAD  A1001 (-4.7A)
 0.96A 2yoeB-2h88A:
undetectable
2yoeC-2h88A:
undetectable		 2yoeB-2h88A:
19.05
2yoeC-2h88A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		5 / 11 GLU A 436
THR A 431
ARG A 205
ARG A 189
GLY A 391
 None
 1.49A 3asoA-2h88A:
1.9
3asoB-2h88A:
0.0
3asoT-2h88A:
0.0		 3asoA-2h88A:
22.47
3asoB-2h88A:
17.01
3asoT-2h88A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		5 / 12 LEU A 157
LEU A 110
THR A  48
VAL A 418
PRO A  52
 None
None
FAD  A1001 (-4.1A)
None
None
 1.25A 3dcjA-2h88A:
2.5
3dcjB-2h88A:
3.0		 3dcjA-2h88A:
16.53
3dcjB-2h88A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		5 / 12 VAL A  24
ALA A  33
ALA A  34
ALA A 425
VAL A 191
 None
 0.90A 3fc6C-2h88A:
undetectable		 3fc6C-2h88A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		5 / 11 GLY A 421
PHE A 420
ALA A  34
ALA A  21
ALA A 394
 None
 1.11A 3g88B-2h88A:
undetectable		 3g88B-2h88A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		5 / 11 SER A  55
THR A  57
ALA A 212
GLY A  30
ALA A  26
 FAD  A1001 (-2.7A)
FAD  A1001 (-3.2A)
None
None
FAD  A1001 (-3.8A)
 1.35A 3mg0H-2h88A:
undetectable
3mg0I-2h88A:
undetectable		 3mg0H-2h88A:
17.90
3mg0I-2h88A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		5 / 11 ARG A 269
LEU A 323
ASP A 351
VAL A 359
ILE A 357
 None
 1.27A 3oxxB-2h88A:
undetectable		 3oxxB-2h88A:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		5 / 12 GLY A  86
ARG A 619
GLY A 405
HIS A 404
SER A 296
 None
 1.35A 3tkaA-2h88A:
undetectable		 3tkaA-2h88A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		5 / 9 GLY A 241
ALA A 240
ALA A 235
ARG A 239
LEU A 181
 None
 1.21A 3ur0C-2h88A:
0.8		 3ur0C-2h88A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		5 / 12 PHE A 249
ASN A 366
GLY A 405
ALA A 550
GLU A 552
 None
 1.23A 3v3oB-2h88A:
8.2		 3v3oB-2h88A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		5 / 12 ALA A  26
THR A  53
ALA A 212
ALA A 178
VAL A  47
 FAD  A1001 (-3.8A)
None
None
FAD  A1001 (-3.5A)
None
 1.07A 4df3A-2h88A:
2.7		 4df3A-2h88A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		5 / 12 ALA A  26
THR A  53
ALA A 212
ALA A 178
VAL A  47
 FAD  A1001 (-3.8A)
None
None
FAD  A1001 (-3.5A)
None
 1.08A 4df3B-2h88A:
undetectable		 4df3B-2h88A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		4 / 8 GLY A 231
THR A 234
MET A 367
GLY A 368
 None
None
None
K  A 622 (-4.4A)
 0.77A 4fo4B-2h88A:
undetectable		 4fo4B-2h88A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		4 / 4 LEU A 503
LEU A 528
GLN A 498
GLU A 467
 None
None
UNL  A1004 ( 4.2A)
None
 1.24A 4i41A-2h88A:
undetectable		 4i41A-2h88A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		4 / 7 ILE A 257
THR A 343
VAL A 321
ASP A 293
 None
 1.39A 4iarA-2h88A:
3.5		 4iarA-2h88A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		5 / 9 THR A 583
GLY A 538
GLY A 368
PHE A 249
GLU A 248
 None
None
K  A 622 (-4.4A)
None
None
 1.17A 4kqiA-2h88A:
undetectable		 4kqiA-2h88A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		3 / 3 HIS A 155
VAL A 418
LEU A 161
 None
 0.70A 4m2vA-2h88A:
undetectable		 4m2vA-2h88A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		5 / 12 TYR A 220
GLY A 369
SER A 229
GLY A 231
THR A 535
 None
K  A 622 ( 4.7A)
FAD  A1001 ( 4.9A)
None
None
 1.06A 4mm8A-2h88A:
undetectable		 4mm8A-2h88A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		5 / 12 HIS A 253
THR A 255
GLU A 266
GLY A 131
GLY A  63
 TEO  A1002 (-4.0A)
None
None
None
FAD  A1001 (-4.1A)
 1.42A 4uinH-2h88A:
undetectable
4uinL-2h88A:
undetectable		 4uinH-2h88A:
16.59
4uinL-2h88A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		3 / 3 LYS A 555
ARG A 551
HIS A 549
 None
 1.15A 4zbrA-2h88A:
undetectable		 4zbrA-2h88A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		5 / 11 SER A 225
THR A 224
ALA A 548
GLU A 266
GLU A 397
 None
FAD  A1001 (-4.7A)
None
None
FAD  A1001 ( 3.7A)
 1.29A 4zjoD-2h88A:
undetectable		 4zjoD-2h88A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		5 / 12 GLY A 132
LEU A 294
VAL A 321
GLN A 133
LEU A 409
 None
 1.15A 5hg0A-2h88A:
undetectable		 5hg0A-2h88A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		5 / 12 LEU A 596
GLY A 538
THR A 535
GLN A 534
LEU A 533
 None
 1.19A 5hg0A-2h88A:
undetectable		 5hg0A-2h88A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		6 / 12 ARG A 484
SER A 545
LEU A 596
GLY A 538
ALA A 539
LEU A 489
 None
 1.30A 5iktA-2h88A:
undetectable		 5iktA-2h88A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		4 / 8 SER A 613
PRO A 616
TYR A 563
SER A  87
 None
 1.09A 5l1fA-2h88A:
undetectable
5l1fB-2h88A:
undetectable		 5l1fA-2h88A:
20.51
5l1fB-2h88A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		5 / 12 SER A  55
THR A  57
ALA A 212
GLY A  30
ALA A  26
 FAD  A1001 (-2.7A)
FAD  A1001 (-3.2A)
None
None
FAD  A1001 (-3.8A)
 1.32A 5l5zH-2h88A:
undetectable
5l5zI-2h88A:
undetectable		 5l5zH-2h88A:
17.42
5l5zI-2h88A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		5 / 12 SER A  55
THR A  57
ALA A 212
GLY A  30
ALA A  26
 FAD  A1001 (-2.7A)
FAD  A1001 (-3.2A)
None
None
FAD  A1001 (-3.8A)
 1.32A 5l5zV-2h88A:
undetectable
5l5zW-2h88A:
undetectable		 5l5zV-2h88A:
17.42
5l5zW-2h88A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_1
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		4 / 4 SER A 400
ASP A 386
HIS A 381
ASP A  92
 None
 1.31A 5x7fA-2h88A:
0.0		 5x7fA-2h88A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		4 / 6 TYR A 287
ILE A 306
GLU A 307
ARG A 312
 None
 0.64A 5z3jA-2h88A:
undetectable		 5z3jA-2h88A:
18.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		3 / 3 HIS A 253
HIS A 364
ARG A 408
 TEO  A1002 (-4.0A)
TEO  A1002 ( 3.8A)
TEO  A1002 ( 2.8A)
 0.56A 6b58A-2h88A:
45.2		 6b58A-2h88A:
39.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		5 / 12 VAL A 363
VAL A 250
PHE A 177
THR A 213
GLY A 214
 None
None
FAD  A1001 ( 3.7A)
FAD  A1001 (-4.3A)
FAD  A1001 ( 3.7A)
 0.81A 6brdC-2h88A:
10.1		 6brdC-2h88A:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		4 / 8 PHE A  51
HIS A 159
VAL A  58
SER A  55
 None
None
None
FAD  A1001 (-2.7A)
 1.24A 6huoC-2h88A:
3.7
6huoD-2h88A:
3.3		 6huoC-2h88A:
9.21
6huoD-2h88A:
9.22