SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h8a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZZN_B_SAMB402_0 (UNCHARACTERIZED PROTEIN MJ0883)	2h8a	MICROSOMAL GLUTATHIONE S-TRANSFERASE 1 (Rattus norvegicus)	5 / 12	PHE A 134 PHE A 109 GLY A 136 ILE A 82 ASN A 81	None	1.25A	2zznB-2h8aA: undetectable	2zznB-2h8aA: 21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4O5F_A_PAUA301_0 (TYPE III PANTOTHENATE KINASE)	2h8a	MICROSOMAL GLUTATHIONE S-TRANSFERASE 1 (Rattus norvegicus)	5 / 12	VAL A 83 TYR A 92 LEU A 91 GLY A 87 THR A 140	None	1.31A	4o5fA-2h8aA: undetectable 4o5fB-2h8aA: undetectable	4o5fA-2h8aA: 18.22 4o5fB-2h8aA: 18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4W5N_A_IPHA901_0 (PROTEIN ARGONAUTE-2)	2h8a	MICROSOMAL GLUTATHIONE S-TRANSFERASE 1 (Rattus norvegicus)	3 / 3	VAL A 110 ALA A 112 PHE A 85	None	0.91A	4w5nA-2h8aA: undetectable	4w5nA-2h8aA: 11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GH9_A_MIXA1003_0 (UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 15)	2h8a	MICROSOMAL GLUTATHIONE S-TRANSFERASE 1 (Rattus norvegicus)	4 / 5	ASN A 77 TYR A 115 GLY A 111 HIS A 116	None	1.30A	6gh9A-2h8aA: undetectable	6gh9A-2h8aA: 21.17

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2ZZN_B_SAMB402_0","UNCHARACTERIZED PROTEIN MJ0883","2h8a","MICROSOMAL GLUTATHIONE S-TRANSFERASE 1","Rattus norvegicus",5,"PHE A 134;PHE A 109;GLY A 136;ILE A  82;ASN A  81","None","1.25A","2zznB-2h8aA:undetectable","2zznB-2h8aA:21.28"],["4O5F_A_PAUA301_0","TYPE III PANTOTHENATE KINASE","2h8a","MICROSOMAL GLUTATHIONE S-TRANSFERASE 1","Rattus norvegicus",5,"VAL A  83;TYR A  92;LEU A  91;GLY A  87;THR A 140","None","1.31A","4o5fA-2h8aA:undetectable;4o5fB-2h8aA:undetectable","4o5fA-2h8aA:18.22;4o5fB-2h8aA:18.22"],["4W5N_A_IPHA901_0","PROTEIN ARGONAUTE-2","2h8a","MICROSOMAL GLUTATHIONE S-TRANSFERASE 1","Rattus norvegicus",3,"VAL A 110;ALA A 112;PHE A  85","None","0.91A","4w5nA-2h8aA:undetectable","4w5nA-2h8aA:11.30"],["6GH9_A_MIXA1003_0","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 15","2h8a","MICROSOMAL GLUTATHIONE S-TRANSFERASE 1","Rattus norvegicus",4,"ASN A  77;TYR A 115;GLY A 111;HIS A 116","None","1.30A","6gh9A-2h8aA:undetectable","6gh9A-2h8aA:21.17"]]