SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h8l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_1
(PHOSPHOLIPASE A2)		 2h8l PROTEIN
DISULFIDE-ISOMERASE
A3
(Homo
sapiens) 		4 / 5 VAL A 325
GLN A 339
PHE A 299
ARG A 304
 None
 1.40A 3bjwE-2h8lA:
undetectable		 3bjwE-2h8lA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 2h8l PROTEIN
DISULFIDE-ISOMERASE
A3
(Homo
sapiens) 		4 / 8 PHE A 148
GLY A 158
PHE A 159
SER A 136
 None
 0.96A 3tzfB-2h8lA:
undetectable		 3tzfB-2h8lA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 2h8l PROTEIN
DISULFIDE-ISOMERASE
A3
(Homo
sapiens) 		4 / 8 PHE A 160
GLY A 158
ILE A 156
ILE A 232
 None
 0.78A 4em2A-2h8lA:
undetectable		 4em2A-2h8lA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 2h8l PROTEIN
DISULFIDE-ISOMERASE
A3
(Homo
sapiens) 		5 / 12 SER A 165
GLY A 202
GLY A 200
THR A 223
ALA A 167
 None
 1.13A 5kpcB-2h8lA:
undetectable		 5kpcB-2h8lA:
21.71