SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h8q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 2h8q RED FLUORESCENT
PROTEIN DRFP583
(Discosoma
sp.) 		5 / 11 LEU A  61
VAL A  22
VAL A 105
GLY A 126
LEU A  54
 None
 1.37A 1fkpA-2h8qA:
undetectable		 1fkpA-2h8qA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 2h8q RED FLUORESCENT
PROTEIN DRFP583
(Discosoma
sp.) 		5 / 12 LEU A 157
GLU A 160
ILE A  79
GLY A 219
HIS A  75
 None
 1.22A 1g50B-2h8qA:
undetectable		 1g50B-2h8qA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 2h8q RED FLUORESCENT
PROTEIN DRFP583
(Discosoma
sp.) 		5 / 11 LEU A 157
GLU A 160
ILE A  79
GLY A 219
HIS A  75
 None
 1.21A 1g50C-2h8qA:
undetectable		 1g50C-2h8qA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 2h8q RED FLUORESCENT
PROTEIN DRFP583
(Discosoma
sp.) 		4 / 5 PRO A 152
LEU A 157
THR A 147
ARG A 220
 None
 0.90A 1i2wA-2h8qA:
undetectable		 1i2wA-2h8qA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2h8q RED FLUORESCENT
PROTEIN DRFP583
(Discosoma
sp.) 		5 / 10 LEU A  61
VAL A  22
VAL A 105
GLY A 126
LEU A  54
 None
 1.44A 1lw0A-2h8qA:
undetectable		 1lw0A-2h8qA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2h8q RED FLUORESCENT
PROTEIN DRFP583
(Discosoma
sp.) 		5 / 11 LEU A  61
VAL A  22
VAL A 105
GLY A 126
LEU A  54
 None
 1.43A 1lwcA-2h8qA:
undetectable		 1lwcA-2h8qA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2h8q RED FLUORESCENT
PROTEIN DRFP583
(Discosoma
sp.) 		4 / 7 ILE A 180
LEU A 189
LEU A 150
GLY A 159
 None
 0.91A 1mt1H-2h8qA:
undetectable
1mt1K-2h8qA:
undetectable		 1mt1H-2h8qA:
19.20
1mt1K-2h8qA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VRT_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2h8q RED FLUORESCENT
PROTEIN DRFP583
(Discosoma
sp.) 		5 / 9 LEU A  61
VAL A  22
VAL A 105
GLY A 126
LEU A  54
 None
 1.40A 1vrtA-2h8qA:
undetectable		 1vrtA-2h8qA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2h8q RED FLUORESCENT
PROTEIN DRFP583
(Discosoma
sp.) 		3 / 3 LEU A  54
PHE A  27
ARG A  95
 None
None
CRQ  A  66 ( 3.0A)
 0.85A 1xdkB-2h8qA:
undetectable		 1xdkB-2h8qA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2h8q RED FLUORESCENT
PROTEIN DRFP583
(Discosoma
sp.) 		5 / 10 LEU A  61
VAL A  22
VAL A 105
GLY A 126
LEU A  54
 None
 1.42A 2hndA-2h8qA:
undetectable		 2hndA-2h8qA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2h8q RED FLUORESCENT
PROTEIN DRFP583
(Discosoma
sp.) 		5 / 10 LEU A  61
VAL A  22
VAL A 105
GLY A 126
LEU A  54
 None
 1.40A 2hnyA-2h8qA:
undetectable		 2hnyA-2h8qA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2h8q RED FLUORESCENT
PROTEIN DRFP583
(Discosoma
sp.) 		4 / 8 ILE A 180
LEU A 189
LEU A 150
GLY A 159
 None
 0.91A 2qqcH-2h8qA:
undetectable
2qqcK-2h8qA:
undetectable		 2qqcH-2h8qA:
18.47
2qqcK-2h8qA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2h8q RED FLUORESCENT
PROTEIN DRFP583
(Discosoma
sp.) 		5 / 12 SER A 179
SER A  62
PHE A 124
ILE A  29
PHE A  56
 None
 1.28A 3aocC-2h8qA:
undetectable		 3aocC-2h8qA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2h8q RED FLUORESCENT
PROTEIN DRFP583
(Discosoma
sp.) 		5 / 10 LEU A  61
VAL A  22
VAL A 105
GLY A 126
LEU A  54
 None
 1.46A 3lp1A-2h8qA:
undetectable		 3lp1A-2h8qA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)		 2h8q RED FLUORESCENT
PROTEIN DRFP583
(Discosoma
sp.) 		5 / 10 LEU A  61
VAL A  22
VAL A 105
GLY A 126
LEU A  54
 None
 1.46A 3qipA-2h8qA:
undetectable		 3qipA-2h8qA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 2h8q RED FLUORESCENT
PROTEIN DRFP583
(Discosoma
sp.) 		5 / 12 PHE A  56
GLN A 213
LEU A  46
VAL A  48
ILE A  29
 None
CRQ  A  66 ( 3.9A)
None
None
None
 1.23A 4k39A-2h8qA:
undetectable		 4k39A-2h8qA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 2h8q RED FLUORESCENT
PROTEIN DRFP583
(Discosoma
sp.) 		4 / 7 GLU A 160
TYR A 192
TYR A 151
GLY A 159
 None
 0.91A 4rdxA-2h8qA:
undetectable		 4rdxA-2h8qA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 2h8q RED FLUORESCENT
PROTEIN DRFP583
(Discosoma
sp.) 		3 / 3 TYR A 214
THR A 202
THR A  43
 None
 0.83A 5aoxE-2h8qA:
undetectable		 5aoxE-2h8qA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 2h8q RED FLUORESCENT
PROTEIN DRFP583
(Discosoma
sp.) 		3 / 3 ILE A 119
MET A  83
ASP A 110
 None
 0.76A 5h2uA-2h8qA:
undetectable		 5h2uA-2h8qA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2h8q RED FLUORESCENT
PROTEIN DRFP583
(Discosoma
sp.) 		5 / 11 LEU A  61
VAL A  22
VAL A 105
GLY A 126
LEU A  54
 None
 1.43A 5hbmA-2h8qA:
undetectable		 5hbmA-2h8qA:
18.23