SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h8r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 2h8r HEPATOCYTE NUCLEAR
FACTOR 1-BETA
(Homo
sapiens) 		3 / 3 VAL A 142
VAL A 140
TRP A 171
 None
 0.96A 1av2A-2h8rA:
undetectable
1av2B-2h8rA:
undetectable		 1av2A-2h8rA:
5.69
1av2B-2h8rA:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 2h8r HEPATOCYTE NUCLEAR
FACTOR 1-BETA
(Homo
sapiens) 		3 / 3 VAL A 142
VAL A 140
TRP A 171
 None
 0.82A 1w5uA-2h8rA:
undetectable
1w5uB-2h8rA:
undetectable		 1w5uA-2h8rA:
5.69
1w5uB-2h8rA:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 2h8r HEPATOCYTE NUCLEAR
FACTOR 1-BETA
(Homo
sapiens) 		3 / 3 VAL A 140
TRP A 171
VAL A 142
 None
 0.93A 2izqC-2h8rA:
undetectable
2izqD-2h8rA:
undetectable		 2izqC-2h8rA:
5.69
2izqD-2h8rA:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2h8r HEPATOCYTE NUCLEAR
FACTOR 1-BETA
(Homo
sapiens) 		4 / 8 ILE A 179
ASN A 269
VAL A 278
GLY A 277
 None
 0.72A 3em0B-2h8rA:
undetectable		 3em0B-2h8rA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2h8r HEPATOCYTE NUCLEAR
FACTOR 1-BETA
(Homo
sapiens) 		4 / 7 GLU A 138
GLU A 178
HIS A 284
VAL A 278
 None
 0.95A 4a97A-2h8rA:
undetectable		 4a97A-2h8rA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2h8r HEPATOCYTE NUCLEAR
FACTOR 1-BETA
(Homo
sapiens) 		4 / 7 GLU A 138
GLU A 178
HIS A 284
VAL A 278
 None
 0.94A 4a97D-2h8rA:
undetectable		 4a97D-2h8rA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2h8r HEPATOCYTE NUCLEAR
FACTOR 1-BETA
(Homo
sapiens) 		4 / 7 GLU A 138
GLU A 178
HIS A 284
VAL A 278
 None
 0.87A 4a97H-2h8rA:
undetectable		 4a97H-2h8rA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 2h8r HEPATOCYTE NUCLEAR
FACTOR 1-BETA
(Homo
sapiens) 		4 / 6 ALA A 167
GLN A 163
LEU A 168
LEU A 114
 None
 1.13A 4xoyA-2h8rA:
undetectable		 4xoyA-2h8rA:
21.66