SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h8x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 2h8x XENOBIOTIC REDUCTASE
A
(Pseudomonas
putida) 		4 / 8 THR A  67
PRO A  68
GLY A  69
CYH A  70
 None
SO4  A1506 ( 4.7A)
None
None
 0.82A 1h4oG-2h8xA:
undetectable		 1h4oG-2h8xA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 2h8x XENOBIOTIC REDUCTASE
A
(Pseudomonas
putida) 		5 / 11 GLY A 182
THR A 270
LEU A 211
GLY A 233
GLU A 236
 None
 1.00A 1i7qA-2h8xA:
undetectable		 1i7qA-2h8xA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 2h8x XENOBIOTIC REDUCTASE
A
(Pseudomonas
putida) 		4 / 8 THR A  67
PRO A  68
GLY A  69
CYH A  70
 None
SO4  A1506 ( 4.7A)
None
None
 0.88A 1oc3A-2h8xA:
undetectable		 1oc3A-2h8xA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 2h8x XENOBIOTIC REDUCTASE
A
(Pseudomonas
putida) 		5 / 12 GLY A 185
LEU A 215
LEU A 211
VAL A 218
ILE A 175
 None
 1.19A 1zq9A-2h8xA:
undetectable		 1zq9A-2h8xA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2h8x XENOBIOTIC REDUCTASE
A
(Pseudomonas
putida) 		4 / 7 GLY A 279
PRO A 280
THR A 306
GLY A 303
 SO4  A1504 (-3.1A)
SO4  A1504 (-4.6A)
None
FMN  A1401 (-4.1A)
 0.82A 2jkjE-2h8xA:
undetectable		 2jkjE-2h8xA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2h8x XENOBIOTIC REDUCTASE
A
(Pseudomonas
putida) 		4 / 7 GLY A 279
PRO A 280
THR A 306
GLY A 303
 SO4  A1504 (-3.1A)
SO4  A1504 (-4.6A)
None
FMN  A1401 (-4.1A)
 0.81A 2jklA-2h8xA:
undetectable		 2jklA-2h8xA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2h8x XENOBIOTIC REDUCTASE
A
(Pseudomonas
putida) 		4 / 7 GLY A 279
PRO A 280
THR A 306
GLY A 303
 SO4  A1504 (-3.1A)
SO4  A1504 (-4.6A)
None
FMN  A1401 (-4.1A)
 0.81A 2jklC-2h8xA:
undetectable		 2jklC-2h8xA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2h8x XENOBIOTIC REDUCTASE
A
(Pseudomonas
putida) 		4 / 7 GLY A 279
PRO A 280
THR A 306
GLY A 303
 SO4  A1504 (-3.1A)
SO4  A1504 (-4.6A)
None
FMN  A1401 (-4.1A)
 0.81A 2jklD-2h8xA:
undetectable		 2jklD-2h8xA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2h8x XENOBIOTIC REDUCTASE
A
(Pseudomonas
putida) 		4 / 7 GLY A 279
PRO A 280
THR A 306
GLY A 303
 SO4  A1504 (-3.1A)
SO4  A1504 (-4.6A)
None
FMN  A1401 (-4.1A)
 0.80A 2jklE-2h8xA:
undetectable		 2jklE-2h8xA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2h8x XENOBIOTIC REDUCTASE
A
(Pseudomonas
putida) 		4 / 7 GLY A 279
PRO A 280
THR A 306
GLY A 303
 SO4  A1504 (-3.1A)
SO4  A1504 (-4.6A)
None
FMN  A1401 (-4.1A)
 0.80A 2jklF-2h8xA:
undetectable		 2jklF-2h8xA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 2h8x XENOBIOTIC REDUCTASE
A
(Pseudomonas
putida) 		4 / 5 LEU A  45
GLY A  48
ILE A  19
ILE A  21
 None
 0.87A 2q9rA-2h8xA:
undetectable		 2q9rA-2h8xA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 2h8x XENOBIOTIC REDUCTASE
A
(Pseudomonas
putida) 		4 / 8 LEU A 260
SER A 208
VAL A 234
GLY A 233
 None
 1.08A 2qd5B-2h8xA:
undetectable		 2qd5B-2h8xA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 2h8x XENOBIOTIC REDUCTASE
A
(Pseudomonas
putida) 		4 / 7 ILE A 286
ARG A 289
TYR A 237
GLU A 242
 None
 1.00A 2qebA-2h8xA:
undetectable		 2qebA-2h8xA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2h8x XENOBIOTIC REDUCTASE
A
(Pseudomonas
putida) 		4 / 7 GLY A 305
GLY A 303
GLU A 341
ALA A 327
 None
FMN  A1401 (-4.1A)
None
None
 0.79A 3fpjB-2h8xA:
undetectable		 3fpjB-2h8xA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2h8x XENOBIOTIC REDUCTASE
A
(Pseudomonas
putida) 		3 / 3 ILE A  89
PHE A 172
HIS A  41
 None
 0.75A 3h0aA-2h8xA:
undetectable		 3h0aA-2h8xA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2h8x XENOBIOTIC REDUCTASE
A
(Pseudomonas
putida) 		5 / 6 VAL A  54
SER A 264
LEU A 314
ALA A  20
LEU A  52
 None
 1.46A 3kk6B-2h8xA:
undetectable		 3kk6B-2h8xA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_1
(PROTEASE)		 2h8x XENOBIOTIC REDUCTASE
A
(Pseudomonas
putida) 		5 / 12 GLY A 171
ALA A 170
ASP A 169
ILE A  73
THR A  58
 None
 0.85A 3s56A-2h8xA:
undetectable		 3s56A-2h8xA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2h8x XENOBIOTIC REDUCTASE
A
(Pseudomonas
putida) 		5 / 12 GLY A  32
GLY A  64
ALA A  59
ARG A 166
ASP A 162
 None
 1.07A 3sugA-2h8xA:
undetectable		 3sugA-2h8xA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPW_A_NCAA412_0
(OLD YELLOW ENZYME
2.6 (OYE2.6), NADPH
DEHYDROGENASE)		 2h8x XENOBIOTIC REDUCTASE
A
(Pseudomonas
putida) 		5 / 9 ALA A 101
HIS A 178
HIS A 181
TYR A 183
TYR A  27
 None
FMN  A1401 ( 3.7A)
SO4  A1507 ( 3.8A)
SO4  A1507 (-4.4A)
None
 1.33A 3upwA-2h8xA:
35.4		 3upwA-2h8xA:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 2h8x XENOBIOTIC REDUCTASE
A
(Pseudomonas
putida) 		4 / 8 HIS A  38
TRP A  37
PRO A 112
TRP A 113
 None
 1.18A 3v35A-2h8xA:
10.3		 3v35A-2h8xA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 2h8x XENOBIOTIC REDUCTASE
A
(Pseudomonas
putida) 		5 / 11 GLY A 239
ASP A 241
VAL A 267
ASN A 275
PRO A 277
 None
 1.22A 3v8vB-2h8xA:
undetectable		 3v8vB-2h8xA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 2h8x XENOBIOTIC REDUCTASE
A
(Pseudomonas
putida) 		4 / 6 HIS A 178
HIS A 181
TYR A 183
TYR A  27
 FMN  A1401 ( 3.7A)
SO4  A1507 ( 3.8A)
SO4  A1507 (-4.4A)
None
 0.95A 4df2A-2h8xA:
35.4		 4df2A-2h8xA:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2h8x XENOBIOTIC REDUCTASE
A
(Pseudomonas
putida) 		5 / 10 ALA A  59
THR A  58
ALA A  57
ALA A 101
GLY A  69
 None
None
FMN  A1401 (-3.1A)
None
None
 0.82A 4qvyK-2h8xA:
undetectable
4qvyL-2h8xA:
undetectable		 4qvyK-2h8xA:
19.67
4qvyL-2h8xA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2h8x XENOBIOTIC REDUCTASE
A
(Pseudomonas
putida) 		5 / 10 ALA A  59
THR A  58
ALA A  57
ALA A 101
GLY A  69
 None
None
FMN  A1401 (-3.1A)
None
None
 0.82A 4qvyY-2h8xA:
undetectable
4qvyZ-2h8xA:
undetectable		 4qvyY-2h8xA:
19.67
4qvyZ-2h8xA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 2h8x XENOBIOTIC REDUCTASE
A
(Pseudomonas
putida) 		3 / 3 ASP A 123
ARG A 111
PRO A  68
 None
SO4  A1506 (-2.9A)
SO4  A1506 ( 4.7A)
 0.83A 4wanC-2h8xA:
undetectable		 4wanC-2h8xA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 2h8x XENOBIOTIC REDUCTASE
A
(Pseudomonas
putida) 		5 / 11 PHE A 210
ALA A 230
VAL A  60
ASP A 159
GLY A 185
 None
 1.21A 4xp4A-2h8xA:
0.0		 4xp4A-2h8xA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2h8x XENOBIOTIC REDUCTASE
A
(Pseudomonas
putida) 		5 / 9 ALA A  59
THR A  58
ALA A  57
ALA A 101
GLY A  69
 None
None
FMN  A1401 (-3.1A)
None
None
 0.94A 5l5zK-2h8xA:
undetectable
5l5zL-2h8xA:
undetectable		 5l5zK-2h8xA:
20.65
5l5zL-2h8xA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2h8x XENOBIOTIC REDUCTASE
A
(Pseudomonas
putida) 		5 / 9 ALA A  59
THR A  58
ALA A  57
ALA A 101
GLY A  69
 None
None
FMN  A1401 (-3.1A)
None
None
 0.94A 5l5zY-2h8xA:
undetectable
5l5zZ-2h8xA:
undetectable		 5l5zY-2h8xA:
20.65
5l5zZ-2h8xA:
21.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OCS_A_ACTA402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 2h8x XENOBIOTIC REDUCTASE
A
(Pseudomonas
putida) 		5 / 5 CYH A  25
ILE A  66
HIS A 178
HIS A 181
TYR A 183
 FMN  A1401 (-3.1A)
None
FMN  A1401 ( 3.7A)
SO4  A1507 ( 3.8A)
SO4  A1507 (-4.4A)
 0.21A 5ocsA-2h8xA:
53.0		 5ocsA-2h8xA:
44.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OCS_C_ACTC402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 2h8x XENOBIOTIC REDUCTASE
A
(Pseudomonas
putida) 		5 / 5 CYH A  25
ILE A  66
HIS A 178
HIS A 181
TYR A 183
 FMN  A1401 (-3.1A)
None
FMN  A1401 ( 3.7A)
SO4  A1507 ( 3.8A)
SO4  A1507 (-4.4A)
 0.21A 5ocsC-2h8xA:
53.0		 5ocsC-2h8xA:
44.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2h8x XENOBIOTIC REDUCTASE
A
(Pseudomonas
putida) 		5 / 12 PRO A  62
GLY A  69
ASP A 123
GLY A 126
ALA A 107
 None
 1.00A 6nj9K-2h8xA:
undetectable		 6nj9K-2h8xA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2h8x XENOBIOTIC REDUCTASE
A
(Pseudomonas
putida) 		3 / 3 ARG A 207
PHE A 179
PHE A 204
 None
 0.87A 6nknC-2h8xA:
undetectable
6nknJ-2h8xA:
undetectable		 6nknC-2h8xA:
21.04
6nknJ-2h8xA:
9.94