SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h92'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 2h92 CYTIDYLATE KINASE
(Staphylococcus
aureus) 		3 / 3 ARG A  87
ARG A 153
ARG A 160
 C5P  A1300 ( 4.8A)
SO4  A1400 ( 3.6A)
None
 0.84A 2jb7A-2h92A:
undetectable
2jb7B-2h92A:
undetectable
2jb7C-2h92A:
undetectable		 2jb7A-2h92A:
21.92
2jb7B-2h92A:
21.92
2jb7C-2h92A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 2h92 CYTIDYLATE KINASE
(Staphylococcus
aureus) 		3 / 3 ARG A 153
ARG A 160
ARG A  87
 SO4  A1400 ( 3.6A)
None
C5P  A1300 ( 4.8A)
 0.82A 2jb7A-2h92A:
undetectable
2jb7B-2h92A:
undetectable
2jb7C-2h92A:
undetectable		 2jb7A-2h92A:
21.92
2jb7B-2h92A:
21.92
2jb7C-2h92A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 2h92 CYTIDYLATE KINASE
(Staphylococcus
aureus) 		3 / 3 ARG A 160
ARG A  87
ARG A 153
 None
C5P  A1300 ( 4.8A)
SO4  A1400 ( 3.6A)
 0.81A 2jb7A-2h92A:
undetectable
2jb7B-2h92A:
undetectable
2jb7C-2h92A:
undetectable		 2jb7A-2h92A:
21.92
2jb7B-2h92A:
21.92
2jb7C-2h92A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2h92 CYTIDYLATE KINASE
(Staphylococcus
aureus) 		4 / 5 SER A  17
GLY A  15
ASP A 168
ASP A 156
 SO4  A1400 (-3.1A)
SO4  A1400 (-3.6A)
None
None
 1.08A 2oxtB-2h92A:
undetectable		 2oxtB-2h92A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 2h92 CYTIDYLATE KINASE
(Staphylococcus
aureus) 		5 / 9 LEU A   8
ALA A  24
VAL A  32
GLY A 120
ILE A   4
 None
 1.21A 3spkA-2h92A:
undetectable		 3spkA-2h92A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 2h92 CYTIDYLATE KINASE
(Staphylococcus
aureus) 		5 / 12 GLY A  15
GLY A  10
ARG A  22
SER A  17
GLU A  26
 SO4  A1400 (-3.6A)
None
None
SO4  A1400 (-3.1A)
None
 1.30A 3tkaA-2h92A:
undetectable		 3tkaA-2h92A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 2h92 CYTIDYLATE KINASE
(Staphylococcus
aureus) 		4 / 5 LYS A  56
LEU A  57
LEU A  48
LYS A  44
 None
 1.24A 4k4yA-2h92A:
undetectable		 4k4yA-2h92A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 2h92 CYTIDYLATE KINASE
(Staphylococcus
aureus) 		4 / 5 LYS A  56
LEU A  57
LEU A  48
LYS A  44
 None
 1.24A 4k4yI-2h92A:
undetectable		 4k4yI-2h92A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 2h92 CYTIDYLATE KINASE
(Staphylococcus
aureus) 		3 / 3 ARG A 152
GLU A 151
PHE A 166
 None
 0.84A 4kszA-2h92A:
undetectable		 4kszA-2h92A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2h92 CYTIDYLATE KINASE
(Staphylococcus
aureus) 		3 / 3 LEU A 169
ILE A 173
ARG A 176
 None
None
C5P  A1300 (-3.1A)
 0.34A 4mk4B-2h92A:
3.0		 4mk4B-2h92A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2h92 CYTIDYLATE KINASE
(Staphylococcus
aureus) 		4 / 6 ALA A  36
GLY A  15
THR A 208
ARG A  87
 None
SO4  A1400 (-3.6A)
None
C5P  A1300 ( 4.8A)
 0.91A 5btgA-2h92A:
undetectable
5btgB-2h92A:
undetectable
5btgC-2h92A:
undetectable		 5btgA-2h92A:
20.33
5btgB-2h92A:
24.26
5btgC-2h92A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 2h92 CYTIDYLATE KINASE
(Staphylococcus
aureus) 		4 / 7 VAL A  95
SER A  96
ALA A  99
ARG A  39
 C5P  A1300 (-4.3A)
C5P  A1300 (-3.6A)
C5P  A1300 ( 3.7A)
C5P  A1300 (-4.0A)
 0.92A 5fpdB-2h92A:
undetectable		 5fpdB-2h92A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2h92 CYTIDYLATE KINASE
(Staphylococcus
aureus) 		4 / 8 LEU A  41
VAL A  82
VAL A  91
LEU A  77
 None
 0.84A 6czmD-2h92A:
undetectable
6czmF-2h92A:
undetectable		 6czmD-2h92A:
21.19
6czmF-2h92A:
21.19