SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2h98'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM
(Acinetobacter
sp.
ADP1) 		5 / 11 LEU A 271
ALA A 245
VAL A 289
LEU A 105
ARG A 156
 None
 1.47A 1kt6A-2h98A:
undetectable		 1kt6A-2h98A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM
(Acinetobacter
sp.
ADP1) 		5 / 12 ILE A 285
ILE A  94
PHE A 144
ASP A 277
LEU A 135
 None
 1.02A 1qhyA-2h98A:
undetectable		 1qhyA-2h98A:
19.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM
(Acinetobacter
sp.
ADP1) 		7 / 9 LEU A 100
LEU A 104
LEU A 105
ILE A 108
PHE A 144
LEU A 159
ILE A 269
 None
 0.66A 2f78A-2h98A:
29.8		 2f78A-2h98A:
41.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM
(Acinetobacter
sp.
ADP1) 		7 / 9 LEU A 100
LEU A 104
LEU A 105
ILE A 108
PHE A 144
LEU A 159
ILE A 269
 None
 0.64A 2f78B-2h98A:
29.8		 2f78B-2h98A:
41.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM
(Acinetobacter
sp.
ADP1) 		4 / 7 VAL A  97
SER A  99
ARG A 146
LEU A 147
 CL  A 315 ( 4.6A)
CL  A 314 (-2.9A)
None
None
 1.10A 2f78B-2h98A:
29.8		 2f78B-2h98A:
41.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM
(Acinetobacter
sp.
ADP1) 		7 / 9 LEU A 100
LEU A 104
LEU A 105
ILE A 108
PHE A 144
LEU A 159
ILE A 269
 None
 0.45A 2f7aA-2h98A:
29.5		 2f7aA-2h98A:
41.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM
(Acinetobacter
sp.
ADP1) 		6 / 9 LEU A 100
LEU A 105
ILE A 108
PHE A 144
LEU A 159
ILE A 269
 None
 0.83A 2f7aB-2h98A:
30.5		 2f7aB-2h98A:
41.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM
(Acinetobacter
sp.
ADP1) 		6 / 9 LEU A 104
LEU A 105
ILE A 108
PHE A 144
LEU A 159
ILE A 269
 None
 0.79A 2f7aB-2h98A:
30.5		 2f7aB-2h98A:
41.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM
(Acinetobacter
sp.
ADP1) 		4 / 6 VAL A  97
SER A  99
ARG A 146
LEU A 147
 CL  A 315 ( 4.6A)
CL  A 314 (-2.9A)
None
None
 1.17A 2f8dA-2h98A:
30.0		 2f8dA-2h98A:
41.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM
(Acinetobacter
sp.
ADP1) 		8 / 10 LEU A 100
GLY A 103
LEU A 104
LEU A 105
ILE A 108
PHE A 144
LEU A 159
ILE A 269
 None
 0.59A 2f8dA-2h98A:
30.0		 2f8dA-2h98A:
41.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM
(Acinetobacter
sp.
ADP1) 		8 / 10 LEU A 100
GLY A 103
LEU A 104
LEU A 105
ILE A 108
PHE A 144
LEU A 159
ILE A 269
 None
 0.64A 2f8dB-2h98A:
31.1		 2f8dB-2h98A:
41.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM
(Acinetobacter
sp.
ADP1) 		3 / 3 LEU A 101
TYR A  96
GLY A 127
 None
None
CL  A 315 ( 3.8A)
 0.42A 2ocuA-2h98A:
6.2		 2ocuA-2h98A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM
(Acinetobacter
sp.
ADP1) 		5 / 12 LEU A 105
LEU A 111
GLN A 115
PHE A 144
LEU A 142
 None
 1.41A 2w8yA-2h98A:
undetectable		 2w8yA-2h98A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM
(Acinetobacter
sp.
ADP1) 		3 / 3 GLY A  95
GLY A 145
GLY A 143
 None
 0.36A 3bogC-2h98A:
undetectable		 3bogC-2h98A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM
(Acinetobacter
sp.
ADP1) 		6 / 12 LEU A 261
ALA A 265
ILE A 207
LEU A 216
VAL A 182
ILE A 260
 None
 1.48A 3em6B-2h98A:
undetectable		 3em6B-2h98A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM
(Acinetobacter
sp.
ADP1) 		5 / 11 LEU A 286
LEU A 142
ILE A 108
LEU A 105
ILE A 269
 None
 1.06A 3tqbA-2h98A:
undetectable		 3tqbA-2h98A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM
(Acinetobacter
sp.
ADP1) 		4 / 7 ALA A 134
ILE A 132
ARG A 274
GLY A 143
 None
 0.97A 3v4tH-2h98A:
undetectable		 3v4tH-2h98A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM
(Acinetobacter
sp.
ADP1) 		4 / 6 LEU A 174
LEU A 166
ILE A 242
MET A 192
 None
 1.00A 4do3B-2h98A:
3.7		 4do3B-2h98A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM
(Acinetobacter
sp.
ADP1) 		5 / 12 LEU A  92
ALA A 272
ILE A 109
GLY A  95
CYH A 126
 None
 1.26A 4hfpB-2h98A:
undetectable		 4hfpB-2h98A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM
(Acinetobacter
sp.
ADP1) 		5 / 12 LEU A 142
VAL A 273
ILE A 282
ILE A 285
ALA A 287
 None
 1.03A 4ltwA-2h98A:
undetectable		 4ltwA-2h98A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM
(Acinetobacter
sp.
ADP1) 		5 / 10 LEU A 271
ILE A 108
LEU A 105
LEU A 286
PHE A 144
 None
 1.05A 4odoA-2h98A:
undetectable		 4odoA-2h98A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM
(Acinetobacter
sp.
ADP1) 		5 / 10 LEU A 271
ILE A 108
LEU A 105
LEU A 286
PHE A 144
 None
 1.02A 4odoB-2h98A:
undetectable		 4odoB-2h98A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM
(Acinetobacter
sp.
ADP1) 		5 / 10 LEU A 271
ILE A 108
LEU A 105
LEU A 286
PHE A 144
 None
 1.07A 4odoC-2h98A:
undetectable		 4odoC-2h98A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM
(Acinetobacter
sp.
ADP1) 		5 / 10 GLY A 251
ALA A 235
VAL A 252
ASP A 249
ILE A 250
 None
 1.07A 5i3cB-2h98A:
undetectable		 5i3cB-2h98A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM
(Acinetobacter
sp.
ADP1) 		5 / 12 LEU A 142
ILE A  94
GLY A  95
THR A 128
VAL A 289
 None
None
None
CL  A 315 (-4.2A)
None
 1.07A 6emuC-2h98A:
undetectable		 6emuC-2h98A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM
(Acinetobacter
sp.
ADP1) 		5 / 12 PRO A 106
ILE A 285
THR A 295
HIS A 296
PHE A 293
 None
 1.49A 6j20A-2h98A:
undetectable		 6j20A-2h98A:
21.66