SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ha8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 2ha8 TAR (HIV-1) RNA LOOP
BINDING PROTEIN
(Homo
sapiens) 		6 / 12 GLY A 129
GLY A 134
ILE A 149
SER A 157
LEU A 158
VAL A 160
 SAH  A 401 (-3.1A)
SAH  A 401 (-3.2A)
SAH  A 401 (-3.8A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-4.3A)
SAH  A 401 (-3.6A)
 0.41A 1v2xA-2ha8A:
19.9		 1v2xA-2ha8A:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 2ha8 TAR (HIV-1) RNA LOOP
BINDING PROTEIN
(Homo
sapiens) 		5 / 11 GLY A 129
GLY A 134
ILE A 149
SER A 157
LEU A 158
 SAH  A 401 (-3.1A)
SAH  A 401 (-3.2A)
SAH  A 401 (-3.8A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-4.3A)
 0.75A 1x7pA-2ha8A:
20.4
1x7pB-2ha8A:
20.8		 1x7pA-2ha8A:
21.95
1x7pB-2ha8A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 2ha8 TAR (HIV-1) RNA LOOP
BINDING PROTEIN
(Homo
sapiens) 		4 / 4 VAL A 160
LEU A  93
ILE A 103
LEU A 143
 SAH  A 401 (-3.6A)
None
None
None
 1.03A 2byoA-2ha8A:
undetectable		 2byoA-2ha8A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2ha8 TAR (HIV-1) RNA LOOP
BINDING PROTEIN
(Homo
sapiens) 		5 / 12 ALA A  75
LEU A  55
SER A  53
ILE A 168
LEU A  27
 None
 1.17A 2oipD-2ha8A:
2.7		 2oipD-2ha8A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2ha8 TAR (HIV-1) RNA LOOP
BINDING PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  42
VAL A  54
SER A  72
SER A  32
GLY A  58
 None
 0.98A 2vmyA-2ha8A:
undetectable		 2vmyA-2ha8A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2ha8 TAR (HIV-1) RNA LOOP
BINDING PROTEIN
(Homo
sapiens) 		3 / 3 LEU A  93
TYR A  92
GLN A  95
 None
 0.72A 2wekA-2ha8A:
2.5		 2wekA-2ha8A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ha8 TAR (HIV-1) RNA LOOP
BINDING PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 129
SER A  32
LEU A  55
LEU A  93
LEU A  89
 SAH  A 401 (-3.1A)
None
None
None
None
 0.79A 3cs8A-2ha8A:
undetectable		 3cs8A-2ha8A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 2ha8 TAR (HIV-1) RNA LOOP
BINDING PROTEIN
(Homo
sapiens) 		5 / 11 GLY A 129
GLY A 134
ILE A 149
LEU A 158
VAL A 160
 SAH  A 401 (-3.1A)
SAH  A 401 (-3.2A)
SAH  A 401 (-3.8A)
SAH  A 401 (-4.3A)
SAH  A 401 (-3.6A)
 0.49A 3dcmX-2ha8A:
13.8		 3dcmX-2ha8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 2ha8 TAR (HIV-1) RNA LOOP
BINDING PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 129
ILE A 149
SER A 157
LEU A 158
SER A 163
 SAH  A 401 (-3.1A)
SAH  A 401 (-3.8A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-4.3A)
SAH  A 401 (-3.0A)
 0.75A 3gyqA-2ha8A:
18.2
3gyqB-2ha8A:
18.4		 3gyqA-2ha8A:
23.25
3gyqB-2ha8A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 2ha8 TAR (HIV-1) RNA LOOP
BINDING PROTEIN
(Homo
sapiens) 		6 / 11 GLY A 129
ILE A 149
SER A 157
LEU A 158
VAL A 160
SER A 163
 SAH  A 401 (-3.1A)
SAH  A 401 (-3.8A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-4.3A)
SAH  A 401 (-3.6A)
SAH  A 401 (-3.0A)
 0.42A 3gyqB-2ha8A:
18.4		 3gyqB-2ha8A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2ha8 TAR (HIV-1) RNA LOOP
BINDING PROTEIN
(Homo
sapiens) 		5 / 12 ALA A  75
LEU A  55
SER A  53
ILE A 168
LEU A  27
 None
 1.15A 3hj3B-2ha8A:
undetectable		 3hj3B-2ha8A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 2ha8 TAR (HIV-1) RNA LOOP
BINDING PROTEIN
(Homo
sapiens) 		8 / 12 ASN A  39
GLY A 129
GLY A 134
ILE A 149
SER A 157
ASN A 159
VAL A 160
SER A 163
 None
SAH  A 401 (-3.1A)
SAH  A 401 (-3.2A)
SAH  A 401 (-3.8A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 (-3.6A)
SAH  A 401 (-3.0A)
 0.39A 3nk7A-2ha8A:
18.8		 3nk7A-2ha8A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 2ha8 TAR (HIV-1) RNA LOOP
BINDING PROTEIN
(Homo
sapiens) 		6 / 12 ASN A  39
LEU A 167
ILE A 149
ASN A 159
VAL A 160
SER A 163
 None
None
SAH  A 401 (-3.8A)
None
SAH  A 401 (-3.6A)
SAH  A 401 (-3.0A)
 1.38A 3nk7A-2ha8A:
18.8		 3nk7A-2ha8A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 2ha8 TAR (HIV-1) RNA LOOP
BINDING PROTEIN
(Homo
sapiens) 		7 / 12 GLY A 129
GLU A 131
GLY A 134
ILE A 149
SER A 157
ASN A 159
SER A 163
 SAH  A 401 (-3.1A)
None
SAH  A 401 (-3.2A)
SAH  A 401 (-3.8A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 (-3.0A)
 1.07A 3nk7A-2ha8A:
18.8		 3nk7A-2ha8A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 2ha8 TAR (HIV-1) RNA LOOP
BINDING PROTEIN
(Homo
sapiens) 		8 / 12 ASN A  39
GLY A 129
GLY A 134
ILE A 149
SER A 157
LEU A 158
VAL A 160
SER A 163
 None
SAH  A 401 (-3.1A)
SAH  A 401 (-3.2A)
SAH  A 401 (-3.8A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-4.3A)
SAH  A 401 (-3.6A)
SAH  A 401 (-3.0A)
 0.48A 3nk7B-2ha8A:
18.7		 3nk7B-2ha8A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 2ha8 TAR (HIV-1) RNA LOOP
BINDING PROTEIN
(Homo
sapiens) 		6 / 12 ASN A  39
LEU A 167
ILE A 149
LEU A 158
VAL A 160
SER A 163
 None
None
SAH  A 401 (-3.8A)
SAH  A 401 (-4.3A)
SAH  A 401 (-3.6A)
SAH  A 401 (-3.0A)
 1.34A 3nk7B-2ha8A:
18.7		 3nk7B-2ha8A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 2ha8 TAR (HIV-1) RNA LOOP
BINDING PROTEIN
(Homo
sapiens) 		6 / 12 GLY A 129
GLU A 131
GLY A 134
ILE A 149
SER A 157
LEU A 158
 SAH  A 401 (-3.1A)
None
SAH  A 401 (-3.2A)
SAH  A 401 (-3.8A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-4.3A)
 0.96A 3nk7B-2ha8A:
18.7		 3nk7B-2ha8A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 2ha8 TAR (HIV-1) RNA LOOP
BINDING PROTEIN
(Homo
sapiens) 		4 / 7 ILE A 135
SER A  32
LEU A 125
VAL A  30
 None
 0.88A 3ua5B-2ha8A:
undetectable		 3ua5B-2ha8A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2ha8 TAR (HIV-1) RNA LOOP
BINDING PROTEIN
(Homo
sapiens) 		5 / 12 ALA A  75
LEU A  55
SER A  53
ILE A 168
LEU A  27
 None
 1.14A 4ky8A-2ha8A:
undetectable		 4ky8A-2ha8A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2ha8 TAR (HIV-1) RNA LOOP
BINDING PROTEIN
(Homo
sapiens) 		5 / 12 ALA A  75
LEU A  55
SER A  53
ILE A 168
LEU A  27
 None
 1.14A 4ky8B-2ha8A:
undetectable		 4ky8B-2ha8A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2ha8 TAR (HIV-1) RNA LOOP
BINDING PROTEIN
(Homo
sapiens) 		5 / 12 ALA A  75
LEU A  55
SER A  53
ILE A 168
LEU A  27
 None
 1.12A 4ky8E-2ha8A:
undetectable		 4ky8E-2ha8A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 2ha8 TAR (HIV-1) RNA LOOP
BINDING PROTEIN
(Homo
sapiens) 		5 / 9 LEU A 128
GLY A 129
ILE A 149
SER A 157
VAL A 160
 SAH  A 401 ( 4.6A)
SAH  A 401 (-3.1A)
SAH  A 401 (-3.8A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-3.6A)
 0.92A 4x3mA-2ha8A:
19.8		 4x3mA-2ha8A:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 2ha8 TAR (HIV-1) RNA LOOP
BINDING PROTEIN
(Homo
sapiens) 		6 / 9 LEU A 128
GLY A 129
ILE A 149
SER A 157
LEU A 158
VAL A 160
 SAH  A 401 ( 4.6A)
SAH  A 401 (-3.1A)
SAH  A 401 (-3.8A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-4.3A)
SAH  A 401 (-3.6A)
 0.81A 4x3mB-2ha8A:
17.1		 4x3mB-2ha8A:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 2ha8 TAR (HIV-1) RNA LOOP
BINDING PROTEIN
(Homo
sapiens) 		6 / 12 GLY A 129
GLY A 134
ILE A 149
GLN A 151
SER A 157
LEU A 158
 SAH  A 401 (-3.1A)
SAH  A 401 (-3.2A)
SAH  A 401 (-3.8A)
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-4.3A)
 0.31A 5l0zA-2ha8A:
20.9		 5l0zA-2ha8A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 2ha8 TAR (HIV-1) RNA LOOP
BINDING PROTEIN
(Homo
sapiens) 		6 / 10 GLY A 129
GLY A 134
ILE A 149
GLN A 151
SER A 157
LEU A 158
 SAH  A 401 (-3.1A)
SAH  A 401 (-3.2A)
SAH  A 401 (-3.8A)
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-4.3A)
 0.55A 5l0zB-2ha8A:
21.2		 5l0zB-2ha8A:
21.84