SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ha9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 2ha9 UPF0210 PROTEIN
SP0239
(Streptococcus
pneumoniae) 		4 / 6 VAL A  58
GLY A  59
ALA A 256
LEU A 260
 None
 0.66A 1e7bB-2ha9A:
undetectable		 1e7bB-2ha9A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2ha9 UPF0210 PROTEIN
SP0239
(Streptococcus
pneumoniae) 		5 / 8 VAL A 118
VAL A 395
VAL A 184
SER A 146
ILE A 133
 None
 1.40A 1igxA-2ha9A:
undetectable		 1igxA-2ha9A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 2ha9 UPF0210 PROTEIN
SP0239
(Streptococcus
pneumoniae) 		3 / 3 ASP A 163
ILE A 156
VAL A 395
 None
 0.57A 2avvD-2ha9A:
undetectable		 2avvD-2ha9A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 2ha9 UPF0210 PROTEIN
SP0239
(Streptococcus
pneumoniae) 		5 / 12 ASP A 126
ILE A 128
GLY A  84
ILE A  83
ALA A 136
 None
 1.08A 2b7zA-2ha9A:
undetectable		 2b7zA-2ha9A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 2ha9 UPF0210 PROTEIN
SP0239
(Streptococcus
pneumoniae) 		5 / 9 GLY A 155
ASN A 157
ILE A 149
ALA A 383
PHE A 185
 None
 1.32A 2drdA-2ha9A:
undetectable		 2drdA-2ha9A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 2ha9 UPF0210 PROTEIN
SP0239
(Streptococcus
pneumoniae) 		4 / 8 ILE A  44
ILE A  48
ARG A  74
VAL A  75
 None
 0.70A 2nniA-2ha9A:
undetectable		 2nniA-2ha9A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 2ha9 UPF0210 PROTEIN
SP0239
(Streptococcus
pneumoniae) 		5 / 10 ILE A 430
ALA A 380
VAL A 184
ILE A 397
VAL A 395
 None
 1.02A 2nnjA-2ha9A:
undetectable		 2nnjA-2ha9A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2ha9 UPF0210 PROTEIN
SP0239
(Streptococcus
pneumoniae) 		5 / 8 GLY A 155
ASN A 157
ILE A 149
ALA A 383
PHE A 185
 None
 1.40A 3aodA-2ha9A:
undetectable		 3aodA-2ha9A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2ha9 UPF0210 PROTEIN
SP0239
(Streptococcus
pneumoniae) 		5 / 12 ILE A 248
ALA A 256
PRO A  69
PHE A  18
VAL A 213
 None
 0.99A 3jb2A-2ha9A:
undetectable		 3jb2A-2ha9A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2ha9 UPF0210 PROTEIN
SP0239
(Streptococcus
pneumoniae) 		5 / 12 ILE A 208
VAL A 207
GLY A 201
ALA A 205
ILE A  83
 None
 1.00A 3mb5A-2ha9A:
undetectable		 3mb5A-2ha9A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2ha9 UPF0210 PROTEIN
SP0239
(Streptococcus
pneumoniae) 		4 / 5 GLY A 313
THR A 246
ILE A 266
VAL A 267
 None
 0.89A 3wriA-2ha9A:
undetectable		 3wriA-2ha9A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 2ha9 UPF0210 PROTEIN
SP0239
(Streptococcus
pneumoniae) 		4 / 5 GLY A 313
THR A 246
ILE A 266
VAL A 267
 None
 0.90A 3wriB-2ha9A:
undetectable		 3wriB-2ha9A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD391_1
(TETX2 PROTEIN)		 2ha9 UPF0210 PROTEIN
SP0239
(Streptococcus
pneumoniae) 		5 / 11 PHE A 114
GLY A 113
SER A 145
GLY A 125
ASN A 131
 None
 1.39A 4a99D-2ha9A:
0.0		 4a99D-2ha9A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 2ha9 UPF0210 PROTEIN
SP0239
(Streptococcus
pneumoniae) 		5 / 12 ILE A 149
ALA A 376
ILE A 133
PRO A 134
ASN A 131
 None
 1.35A 4gh8B-2ha9A:
undetectable		 4gh8B-2ha9A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 2ha9 UPF0210 PROTEIN
SP0239
(Streptococcus
pneumoniae) 		4 / 8 VAL A   6
LEU A 251
ILE A  20
VAL A  58
 None
 0.91A 4ma7A-2ha9A:
undetectable		 4ma7A-2ha9A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2ha9 UPF0210 PROTEIN
SP0239
(Streptococcus
pneumoniae) 		4 / 8 ALA A  40
ALA A  41
ILE A  44
LEU A  99
 None
 0.51A 4v1fA-2ha9A:
undetectable
4v1fB-2ha9A:
undetectable		 4v1fA-2ha9A:
13.33
4v1fB-2ha9A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 2ha9 UPF0210 PROTEIN
SP0239
(Streptococcus
pneumoniae) 		4 / 6 ASN A 422
THR A 370
PRO A 371
THR A 374
 None
 1.03A 4yoaA-2ha9A:
undetectable		 4yoaA-2ha9A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2ha9 UPF0210 PROTEIN
SP0239
(Streptococcus
pneumoniae) 		5 / 12 ALA A 188
PRO A  79
PHE A 199
GLY A 112
SER A 146
 None
 1.30A 5hfjA-2ha9A:
undetectable		 5hfjA-2ha9A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2ha9 UPF0210 PROTEIN
SP0239
(Streptococcus
pneumoniae) 		5 / 12 ALA A 188
PRO A  79
PHE A 199
GLY A 112
SER A 146
 None
 1.28A 5hfjC-2ha9A:
undetectable		 5hfjC-2ha9A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2ha9 UPF0210 PROTEIN
SP0239
(Streptococcus
pneumoniae) 		5 / 9 MET A 288
GLY A 215
ALA A 222
VAL A 218
ILE A 245
 None
 0.79A 5i3cA-2ha9A:
undetectable		 5i3cA-2ha9A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2ha9 UPF0210 PROTEIN
SP0239
(Streptococcus
pneumoniae) 		5 / 10 MET A 288
GLY A 215
ALA A 222
VAL A 218
ILE A 245
 None
 0.80A 5i3cB-2ha9A:
undetectable		 5i3cB-2ha9A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2ha9 UPF0210 PROTEIN
SP0239
(Streptococcus
pneumoniae) 		5 / 11 MET A 288
GLY A 215
ALA A 222
VAL A 218
ILE A 245
 None
 0.82A 5i3cC-2ha9A:
undetectable		 5i3cC-2ha9A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2ha9 UPF0210 PROTEIN
SP0239
(Streptococcus
pneumoniae) 		5 / 11 MET A 288
GLY A 215
ALA A 222
VAL A 218
SER A 270
 None
 1.01A 5i3cC-2ha9A:
undetectable		 5i3cC-2ha9A:
21.81