SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hae'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 2hae MALATE
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 12 GLU A 351
ALA A 345
LEU A 199
PHE A 299
PHE A 279
 None
 1.34A 1nw3A-2haeA:
4.7		 1nw3A-2haeA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1U_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 2hae MALATE
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 10 ILE A 332
VAL A 372
VAL A 326
GLY A 324
LEU A 337
 None
 1.34A 1s1uA-2haeA:
undetectable		 1s1uA-2haeA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2hae MALATE
OXIDOREDUCTASE
(Thermotoga
maritima) 		4 / 8 PHE A 318
GLY A 158
VAL A 161
LEU A 337
 None
 0.79A 3bgdB-2haeA:
5.4		 3bgdB-2haeA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 2hae MALATE
OXIDOREDUCTASE
(Thermotoga
maritima) 		4 / 7 VAL A 301
MET A 272
ILE A 269
ILE A 288
 None
 0.98A 3hgxA-2haeA:
undetectable		 3hgxA-2haeA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2hae MALATE
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 12 ASN A 127
ASP A 154
VAL A 162
GLY A 320
ILE A 321
 None
 1.20A 3k13A-2haeA:
undetectable		 3k13A-2haeA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2hae MALATE
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 12 ASN A 127
ASP A 154
VAL A 162
GLY A 320
ILE A 321
 None
 1.20A 3k13B-2haeA:
undetectable		 3k13B-2haeA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2hae MALATE
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 12 ASN A 127
ASP A 154
VAL A 162
GLY A 320
ILE A 321
 None
 1.20A 3k13C-2haeA:
undetectable		 3k13C-2haeA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 2hae MALATE
OXIDOREDUCTASE
(Thermotoga
maritima) 		4 / 5 PHE A 255
ILE A 300
ASN A 262
PHE A 254
 None
 1.34A 3octA-2haeA:
undetectable		 3octA-2haeA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2hae MALATE
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 9 ASN A 217
ILE A 215
GLY A 243
THR A 247
ASP A 220
 None
 1.27A 4fxsA-2haeA:
undetectable		 4fxsA-2haeA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 2hae MALATE
OXIDOREDUCTASE
(Thermotoga
maritima) 		4 / 8 GLY A 192
TYR A 228
LYS A 197
GLU A 231
 None
 0.89A 4hyfB-2haeA:
undetectable		 4hyfB-2haeA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 2hae MALATE
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 12 SER A 144
LEU A 143
ASP A 155
ASP A 130
GLY A 132
 None
 1.32A 4j7xF-2haeA:
2.5		 4j7xF-2haeA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 2hae MALATE
OXIDOREDUCTASE
(Thermotoga
maritima) 		4 / 4 VAL A 372
ALA A 376
ILE A 332
THR A 333
 None
 1.02A 5e4dB-2haeA:
undetectable		 5e4dB-2haeA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2hae MALATE
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 8 VAL A 204
VAL A 312
ILE A 355
ILE A 300
PHE A 254
 None
 1.32A 5hi2A-2haeA:
undetectable		 5hi2A-2haeA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 2hae MALATE
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 12 GLU A 287
GLY A 304
ASN A 283
ASN A 314
VAL A 162
 None
 1.38A 5kbwB-2haeA:
undetectable		 5kbwB-2haeA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 2hae MALATE
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 11 ALA A 248
THR A 247
VAL A 208
GLY A 251
ALA A 252
 None
 0.80A 5lf7K-2haeA:
undetectable
5lf7L-2haeA:
undetectable		 5lf7K-2haeA:
22.22
5lf7L-2haeA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 2hae MALATE
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 11 ALA A 248
THR A 247
VAL A 208
GLY A 251
ALA A 252
 None
 0.81A 5lf7Y-2haeA:
undetectable
5lf7Z-2haeA:
undetectable		 5lf7Y-2haeA:
22.22
5lf7Z-2haeA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2hae MALATE
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 12 VAL A 163
LEU A 199
VAL A 196
GLY A 192
PHE A 152
 None
 1.15A 6a94B-2haeA:
undetectable		 6a94B-2haeA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2hae MALATE
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 12 VAL A 163
THR A 159
LEU A 199
GLY A 192
PHE A 152
 None
 1.14A 6a94B-2haeA:
undetectable		 6a94B-2haeA:
22.57