SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hak'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens) 		4 / 7 LEU A  55
ALA A  70
VAL A  79
VAL A 128
 None
 0.86A 1epbA-2hakA:
undetectable		 1epbA-2hakA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		 2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens) 		5 / 11 LEU A 176
VAL A 172
CYH A 166
GLY A 195
LEU A 181
 None
 1.42A 1jkhA-2hakA:
undetectable
1jkhB-2hakA:
undetectable		 1jkhA-2hakA:
18.90
1jkhB-2hakA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens) 		5 / 9 VAL A  67
ALA A  80
TYR A 131
ALA A 132
LEU A 182
 None
 0.45A 1muoA-2hakA:
13.9		 1muoA-2hakA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens) 		6 / 12 VAL A  67
ALA A  80
MET A 104
VAL A 113
GLY A 135
ALA A 192
 None
 0.86A 1opjB-2hakA:
8.8		 1opjB-2hakA:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens) 		4 / 8 GLY A 293
GLU A 230
GLU A 219
ILE A 298
 None
 0.67A 1pk7B-2hakA:
undetectable		 1pk7B-2hakA:
22.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens) 		6 / 11 GLY A  60
VAL A  67
ALA A  80
MET A 129
TYR A 131
ALA A 132
 None
 0.54A 2evaA-2hakA:
19.4		 2evaA-2hakA:
31.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens) 		4 / 6 LEU A 240
LEU A 285
GLU A 278
MET A 273
 None
 1.23A 2kuhA-2hakA:
0.2		 2kuhA-2hakA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens) 		5 / 8 ALA A 217
GLU A 219
LEU A 236
VAL A 163
ILE A 191
 None
 1.33A 2uxpA-2hakA:
0.2		 2uxpA-2hakA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens) 		3 / 3 GLY A 265
PRO A 249
LEU A 285
 None
 0.58A 3hcpB-2hakA:
undetectable		 3hcpB-2hakA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens) 		4 / 5 ILE A 103
VAL A 113
LEU A 182
ASP A 193
 None
 1.16A 3wzdA-2hakA:
14.6		 3wzdA-2hakA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens) 		4 / 5 LYS A  82
VAL A 113
LEU A 182
ASP A 193
 None
 1.02A 3wzdA-2hakA:
14.6		 3wzdA-2hakA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens) 		5 / 9 ILE A 103
LEU A 107
ILE A 112
TYR A 131
ILE A 191
 None
 0.66A 3zosA-2hakA:
20.3		 3zosA-2hakA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens) 		5 / 9 ILE A 103
LEU A 107
ILE A 112
TYR A 131
ILE A 191
 None
 0.68A 3zosB-2hakA:
20.2		 3zosB-2hakA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens) 		4 / 5 VAL A  67
ILE A 112
TYR A 131
ILE A 191
 None
 0.79A 4c8bA-2hakA:
20.1		 4c8bA-2hakA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens) 		6 / 10 GLY A  60
GLY A  62
VAL A  67
ALA A  80
TYR A 131
ALA A 132
 None
 0.52A 4ckjA-2hakA:
19.6		 4ckjA-2hakA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens) 		7 / 12 VAL A  67
ALA A  80
ILE A 103
MET A 104
VAL A 113
TYR A 131
ALA A 192
 None
 0.90A 4csvA-2hakA:
13.3		 4csvA-2hakA:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens) 		7 / 12 VAL A  67
ILE A 103
MET A 104
VAL A 113
TYR A 131
LEU A 182
ALA A 192
 None
 1.11A 4csvA-2hakA:
13.3		 4csvA-2hakA:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens) 		6 / 12 GLY A  60
VAL A  67
ALA A  80
LYS A  82
LEU A 115
LEU A 127
 None
 0.29A 4ifgA-2hakA:
21.4		 4ifgA-2hakA:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens) 		4 / 8 VAL A 172
TYR A 226
HIS A 167
LEU A 236
 None
 1.02A 4jtrA-2hakA:
undetectable		 4jtrA-2hakA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens) 		5 / 8 GLY A  62
VAL A  67
ALA A  80
LYS A  82
MET A 129
 None
 0.63A 4l9iB-2hakA:
14.3		 4l9iB-2hakA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens) 		7 / 12 ILE A  59
GLY A  60
VAL A  67
ALA A  80
MET A 129
TYR A 131
LEU A 182
 None
 0.83A 4qmzA-2hakA:
21.6		 4qmzA-2hakA:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens) 		3 / 3 ASP A 227
ARG A 292
PRO A 289
 None
 0.60A 4wanC-2hakA:
undetectable		 4wanC-2hakA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens) 		3 / 3 SER A 235
GLU A 230
ASP A 175
 None
 0.84A 4xudA-2hakA:
undetectable		 4xudA-2hakA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens) 		4 / 5 ILE A 112
ILE A 106
TYR A 165
GLU A 318
 None
 1.05A 4zzcE-2hakA:
undetectable		 4zzcE-2hakA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens) 		5 / 12 LEU A 243
ILE A 239
LEU A 236
PRO A 229
LEU A 183
 None
 0.95A 5ienA-2hakA:
undetectable		 5ienA-2hakA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens) 		5 / 9 ILE A  59
GLY A  60
VAL A  67
ALA A  80
MET A 129
 None
 0.51A 5lw1B-2hakA:
21.0		 5lw1B-2hakA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens) 		6 / 12 LEU A  69
ALA A  80
MET A 104
VAL A 113
GLY A 134
LEU A 182
 None
 1.01A 5te0A-2hakA:
22.0		 5te0A-2hakA:
28.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens) 		6 / 12 LEU A  69
ALA A  80
MET A 104
VAL A 113
GLY A 135
LEU A 182
 None
 0.88A 5te0A-2hakA:
22.0		 5te0A-2hakA:
28.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens) 		7 / 12 VAL A  67
ALA A  80
MET A 104
TYR A 131
ALA A 132
GLY A 135
ALA A 192
 None
 0.96A 5zv2A-2hakA:
20.5		 5zv2A-2hakA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens) 		7 / 12 VAL A  67
ALA A  80
LYS A  82
MET A 104
ALA A 132
GLY A 135
ALA A 192
 None
 1.01A 5zv2B-2hakA:
13.6		 5zv2B-2hakA:
14.09