SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hal'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2hal HEPATITIS A PROTEASE
3C
(Hepatovirus
A) 		4 / 8 SER A 178
SER A 179
GLU A 132
GLY A 133
 None
 0.68A 1meiA-2halA:
undetectable		 1meiA-2halA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 2hal HEPATITIS A PROTEASE
3C
(Hepatovirus
A) 		5 / 12 ALA A 193
GLY A 194
GLY A 195
ASP A  84
ASP A 158
 None
 0.96A 1sqfA-2halA:
undetectable		 1sqfA-2halA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 2hal HEPATITIS A PROTEASE
3C
(Hepatovirus
A) 		4 / 7 GLY A 174
PHE A 103
ILE A  99
PHE A 209
 None
 1.01A 2qmzA-2halA:
undetectable
2qmzB-2halA:
undetectable		 2qmzA-2halA:
25.51
2qmzB-2halA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 2hal HEPATITIS A PROTEASE
3C
(Hepatovirus
A) 		3 / 3 ASP A  51
THR A 152
GLU A  49
 None
 0.82A 2zifB-2halA:
undetectable		 2zifB-2halA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2hal HEPATITIS A PROTEASE
3C
(Hepatovirus
A) 		5 / 12 HIS A 191
ALA A 160
VAL A 204
GLY A 189
VAL A 157
 None
 1.12A 3f8wC-2halA:
undetectable		 3f8wC-2halA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2hal HEPATITIS A PROTEASE
3C
(Hepatovirus
A) 		5 / 12 HIS A  44
ASP A  84
ARG A 162
GLY A 170
ALA A 193
 None
 1.03A 3sueB-2halA:
9.8		 3sueB-2halA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEE_B_RXMB601_0
(SCAFFOLD PROTEIN D13)		 2hal HEPATITIS A PROTEASE
3C
(Hepatovirus
A) 		5 / 9 GLN A  15
PHE A  96
VAL A 204
PHE A  16
PHE A 209
 None
 1.24A 6beeA-2halA:
0.0
6beeB-2halA:
0.0
6beeC-2halA:
0.0		 6beeA-2halA:
18.17
6beeB-2halA:
18.17
6beeC-2halA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEH_A_RPTA601_1
(SCAFFOLD PROTEIN D13)		 2hal HEPATITIS A PROTEASE
3C
(Hepatovirus
A) 		5 / 10 GLN A  15
PHE A  96
VAL A 204
PHE A  16
PHE A 209
 None
 1.25A 6behA-2halA:
0.5
6behB-2halA:
0.0
6behC-2halA:
0.0		 6behA-2halA:
18.17
6behB-2halA:
18.17
6behC-2halA:
18.17