SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hb6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2hb6 LEUCINE
AMINOPEPTIDASE 1
(Caenorhabditis
elegans) 		3 / 3 GLN A  43
ILE A  59
HIS A  65
 None
 0.69A 1fm9A-2hb6A:
undetectable		 1fm9A-2hb6A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 2hb6 LEUCINE
AMINOPEPTIDASE 1
(Caenorhabditis
elegans) 		4 / 6 ILE A 220
LYS A 252
ALA A 279
VAL A 305
 None
NA  A3001 ( 2.3A)
None
None
 1.02A 1hk1A-2hb6A:
undetectable		 1hk1A-2hb6A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2hb6 LEUCINE
AMINOPEPTIDASE 1
(Caenorhabditis
elegans) 		3 / 3 GLN A  43
ILE A  59
HIS A  65
 None
 0.66A 1k74A-2hb6A:
undetectable		 1k74A-2hb6A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 2hb6 LEUCINE
AMINOPEPTIDASE 1
(Caenorhabditis
elegans) 		5 / 10 GLU A 350
ALA A 354
ALA A 348
PHE A 346
GLY A 344
 None
 1.15A 1mjqG-2hb6A:
undetectable
1mjqH-2hb6A:
undetectable		 1mjqG-2hb6A:
12.76
1mjqH-2hb6A:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 2hb6 LEUCINE
AMINOPEPTIDASE 1
(Caenorhabditis
elegans) 		4 / 7 TYR A 471
THR A 364
SER A 371
VAL A 400
 None
 1.21A 1tv8A-2hb6A:
undetectable		 1tv8A-2hb6A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 2hb6 LEUCINE
AMINOPEPTIDASE 1
(Caenorhabditis
elegans) 		4 / 4 LEU A 249
LEU A 236
SER A 237
LEU A 352
 None
 1.12A 1ya3A-2hb6A:
undetectable		 1ya3A-2hb6A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 2hb6 LEUCINE
AMINOPEPTIDASE 1
(Caenorhabditis
elegans) 		4 / 8 PRO A 103
LEU A  17
GLY A  16
LEU A  71
 None
 0.85A 1ya4A-2hb6A:
3.0		 1ya4A-2hb6A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 2hb6 LEUCINE
AMINOPEPTIDASE 1
(Caenorhabditis
elegans) 		4 / 6 LEU A 166
LEU A 163
LEU A 489
LEU A 289
 None
 0.93A 2ab2A-2hb6A:
undetectable		 2ab2A-2hb6A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 2hb6 LEUCINE
AMINOPEPTIDASE 1
(Caenorhabditis
elegans) 		4 / 7 TYR A 471
THR A 364
SER A 371
VAL A 400
 None
 1.13A 2fb2B-2hb6A:
undetectable		 2fb2B-2hb6A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)		 2hb6 LEUCINE
AMINOPEPTIDASE 1
(Caenorhabditis
elegans) 		5 / 11 LEU A  74
ALA A  42
VAL A 112
ILE A  10
ILE A  22
 None
 0.98A 2idwA-2hb6A:
undetectable		 2idwA-2hb6A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2hb6 LEUCINE
AMINOPEPTIDASE 1
(Caenorhabditis
elegans) 		5 / 8 LEU A 283
ALA A 279
MET A 276
LEU A 184
ASP A 178
 None
 1.37A 2yfxA-2hb6A:
undetectable		 2yfxA-2hb6A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 2hb6 LEUCINE
AMINOPEPTIDASE 1
(Caenorhabditis
elegans) 		4 / 7 SER A 295
SER A 485
GLU A 158
ASP A 159
 None
 1.15A 3bc9A-2hb6A:
undetectable		 3bc9A-2hb6A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 2hb6 LEUCINE
AMINOPEPTIDASE 1
(Caenorhabditis
elegans) 		5 / 12 ASP A 257
GLY A 259
THR A 364
ALA A 335
SER A 424
 NA  A3002 ( 3.1A)
None
None
SO4  A 492 (-4.2A)
None
 1.29A 3d91B-2hb6A:
undetectable		 3d91B-2hb6A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 2hb6 LEUCINE
AMINOPEPTIDASE 1
(Caenorhabditis
elegans) 		5 / 12 GLY A 442
GLY A 337
GLY A 438
VAL A 254
ILE A 340
 None
SO4  A 492 (-3.3A)
None
None
None
 1.05A 3eluA-2hb6A:
undetectable		 3eluA-2hb6A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2hb6 LEUCINE
AMINOPEPTIDASE 1
(Caenorhabditis
elegans) 		3 / 3 LYS A 482
ARG A 452
LEU A 479
 GOL  A2012 (-3.3A)
GOL  A2012 (-3.0A)
None
 1.36A 3v4tE-2hb6A:
undetectable		 3v4tE-2hb6A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2hb6 LEUCINE
AMINOPEPTIDASE 1
(Caenorhabditis
elegans) 		4 / 8 LEU A 289
VAL A 486
TYR A 483
LEU A 298
 None
 1.11A 3v81A-2hb6A:
1.0		 3v81A-2hb6A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2hb6 LEUCINE
AMINOPEPTIDASE 1
(Caenorhabditis
elegans) 		5 / 8 ASP A 413
GLY A 412
PHE A 411
VAL A 328
SER A 324
 None
None
GOL  A2005 ( 4.6A)
None
None
 1.06A 4acbB-2hb6A:
undetectable
4acbC-2hb6A:
2.3		 4acbB-2hb6A:
23.65
4acbC-2hb6A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2hb6 LEUCINE
AMINOPEPTIDASE 1
(Caenorhabditis
elegans) 		4 / 7 VAL A 120
VAL A 124
ASN A 157
VAL A 146
 None
 0.83A 4e1gB-2hb6A:
undetectable		 4e1gB-2hb6A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2hb6 LEUCINE
AMINOPEPTIDASE 1
(Caenorhabditis
elegans) 		5 / 10 GLY A 438
MET A 379
ASN A 331
PHE A 411
PHE A 447
 None
None
None
GOL  A2005 ( 4.6A)
GOL  A2005 (-4.7A)
 1.30A 4fgkA-2hb6A:
1.9
4fgkB-2hb6A:
3.1		 4fgkA-2hb6A:
20.49
4fgkB-2hb6A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 2hb6 LEUCINE
AMINOPEPTIDASE 1
(Caenorhabditis
elegans) 		6 / 12 GLY A 219
GLY A 218
ASN A 307
GLY A 260
PRO A 316
LEU A 261
 None
 1.50A 4fp9A-2hb6A:
undetectable		 4fp9A-2hb6A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 2hb6 LEUCINE
AMINOPEPTIDASE 1
(Caenorhabditis
elegans) 		6 / 12 GLY A 219
GLY A 218
ASN A 307
GLY A 260
PRO A 316
LEU A 261
 None
 1.49A 4fp9C-2hb6A:
undetectable		 4fp9C-2hb6A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 2hb6 LEUCINE
AMINOPEPTIDASE 1
(Caenorhabditis
elegans) 		6 / 12 GLY A 219
GLY A 218
ASN A 307
GLY A 260
PRO A 316
LEU A 261
 None
 1.49A 4fzvA-2hb6A:
undetectable		 4fzvA-2hb6A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 2hb6 LEUCINE
AMINOPEPTIDASE 1
(Caenorhabditis
elegans) 		5 / 12 ILE A  22
ALA A  72
THR A   2
VAL A   4
LEU A  97
 None
 1.25A 4qzuA-2hb6A:
undetectable		 4qzuA-2hb6A:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 2hb6 LEUCINE
AMINOPEPTIDASE 1
(Caenorhabditis
elegans) 		5 / 12 ASP A 382
GLU A 388
LEU A 249
LEU A 298
THR A 297
 None
GOL  A2012 (-3.1A)
None
None
None
 1.40A 5hnxB-2hb6A:
undetectable		 5hnxB-2hb6A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2hb6 LEUCINE
AMINOPEPTIDASE 1
(Caenorhabditis
elegans) 		4 / 7 GLY A 227
VAL A 254
ASP A 257
VAL A 255
 None
None
NA  A3002 ( 3.1A)
None
 0.81A 5ik1A-2hb6A:
undetectable		 5ik1A-2hb6A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 2hb6 LEUCINE
AMINOPEPTIDASE 1
(Caenorhabditis
elegans) 		4 / 7 ILE A 441
LEU A 440
MET A 421
LEU A 414
 None
 1.03A 5u4sA-2hb6A:
2.1		 5u4sA-2hb6A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 2hb6 LEUCINE
AMINOPEPTIDASE 1
(Caenorhabditis
elegans) 		4 / 8 ILE A 441
LEU A 440
MET A 421
LEU A 414
 None
 1.06A 5u4sB-2hb6A:
2.0		 5u4sB-2hb6A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2hb6 LEUCINE
AMINOPEPTIDASE 1
(Caenorhabditis
elegans) 		5 / 12 LEU A 212
PHE A 346
GLY A 344
LEU A 440
ILE A 340
 None
 1.19A 5y2tA-2hb6A:
undetectable		 5y2tA-2hb6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2hb6 LEUCINE
AMINOPEPTIDASE 1
(Caenorhabditis
elegans) 		3 / 3 GLN A  43
ILE A  59
HIS A  65
 None
 0.61A 5z12B-2hb6A:
undetectable		 5z12B-2hb6A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 2hb6 LEUCINE
AMINOPEPTIDASE 1
(Caenorhabditis
elegans) 		4 / 6 SER A  92
ALA A  61
SER A  62
ALA A  80
 None
 1.03A 6bocA-2hb6A:
undetectable
6bocB-2hb6A:
undetectable
6bocC-2hb6A:
undetectable
6bocD-2hb6A:
undetectable		 6bocA-2hb6A:
5.60
6bocB-2hb6A:
5.60
6bocC-2hb6A:
5.60
6bocD-2hb6A:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 2hb6 LEUCINE
AMINOPEPTIDASE 1
(Caenorhabditis
elegans) 		5 / 9 VAL A 255
LEU A 283
ALA A 193
VAL A 194
ASP A 191
 None
 1.36A 6c2mB-2hb6A:
undetectable		 6c2mB-2hb6A:
10.28