SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hbw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2hbw NLP/P60 PROTEIN
(Trichormus
variabilis) 		5 / 12 ASP A 164
THR A 104
ILE A 101
SER A 136
PHE A 134
 None
 1.34A 1xoqA-2hbwA:
undetectable		 1xoqA-2hbwA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2hbw NLP/P60 PROTEIN
(Trichormus
variabilis) 		5 / 12 ASP A 164
THR A 104
ILE A 101
SER A 136
PHE A 134
 None
 1.36A 1xoqB-2hbwA:
undetectable		 1xoqB-2hbwA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 2hbw NLP/P60 PROTEIN
(Trichormus
variabilis) 		5 / 8 TYR A 146
TYR A  64
GLY A 117
THR A  36
ALA A  35
 None
UNL  A 237 (-4.9A)
UNL  A 237 ( 3.7A)
None
UNL  A 237 (-4.7A)
 1.27A 2a1hA-2hbwA:
undetectable
2a1hB-2hbwA:
undetectable		 2a1hA-2hbwA:
23.26
2a1hB-2hbwA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 2hbw NLP/P60 PROTEIN
(Trichormus
variabilis) 		4 / 8 TYR A 114
ASP A 125
SER A 127
HIS A 176
 ACT  A 236 (-4.2A)
UNL  A 237 (-3.8A)
UNL  A 237 (-2.6A)
ACT  A 236 (-3.7A)
 1.29A 2bteA-2hbwA:
undetectable		 2bteA-2hbwA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 2hbw NLP/P60 PROTEIN
(Trichormus
variabilis) 		4 / 8 TYR A 114
ASP A 125
SER A 127
HIS A 176
 ACT  A 236 (-4.2A)
UNL  A 237 (-3.8A)
UNL  A 237 (-2.6A)
ACT  A 236 (-3.7A)
 1.35A 2bteD-2hbwA:
undetectable		 2bteD-2hbwA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 2hbw NLP/P60 PROTEIN
(Trichormus
variabilis) 		5 / 12 CYH A  60
LEU A  25
LEU A  68
VAL A  46
LEU A  76
 None
 1.08A 2bxfA-2hbwA:
undetectable		 2bxfA-2hbwA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 2hbw NLP/P60 PROTEIN
(Trichormus
variabilis) 		5 / 10 TYR A  64
GLY A 117
THR A  36
ALA A  35
TYR A 146
 UNL  A 237 (-4.9A)
UNL  A 237 ( 3.7A)
None
UNL  A 237 (-4.7A)
None
 1.29A 2coiA-2hbwA:
undetectable
2coiB-2hbwA:
undetectable		 2coiA-2hbwA:
20.98
2coiB-2hbwA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 2hbw NLP/P60 PROTEIN
(Trichormus
variabilis) 		5 / 10 TYR A 146
TYR A  64
GLY A 117
THR A  36
ALA A  35
 None
UNL  A 237 (-4.9A)
UNL  A 237 ( 3.7A)
None
UNL  A 237 (-4.7A)
 1.26A 2coiA-2hbwA:
undetectable
2coiB-2hbwA:
undetectable		 2coiA-2hbwA:
20.98
2coiB-2hbwA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 2hbw NLP/P60 PROTEIN
(Trichormus
variabilis) 		5 / 11 TYR A  64
GLY A 117
THR A  36
ALA A  35
TYR A 146
 UNL  A 237 (-4.9A)
UNL  A 237 ( 3.7A)
None
UNL  A 237 (-4.7A)
None
 1.25A 2cojA-2hbwA:
undetectable
2cojB-2hbwA:
undetectable		 2cojA-2hbwA:
20.98
2cojB-2hbwA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 2hbw NLP/P60 PROTEIN
(Trichormus
variabilis) 		5 / 9 TYR A 146
TYR A  64
GLY A 117
THR A  36
ALA A  35
 None
UNL  A 237 (-4.9A)
UNL  A 237 ( 3.7A)
None
UNL  A 237 (-4.7A)
 1.24A 2cojA-2hbwA:
undetectable
2cojB-2hbwA:
undetectable		 2cojA-2hbwA:
20.98
2cojB-2hbwA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2hbw NLP/P60 PROTEIN
(Trichormus
variabilis) 		5 / 12 GLY A 223
GLY A 221
VAL A 177
THR A 152
LEU A 141
 None
 1.12A 3dh0B-2hbwA:
undetectable		 3dh0B-2hbwA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2hbw NLP/P60 PROTEIN
(Trichormus
variabilis) 		5 / 12 LEU A 115
ASP A 125
SER A 127
ALA A 132
LEU A  23
 None
UNL  A 237 (-3.8A)
UNL  A 237 (-2.6A)
None
None
 1.23A 4nc3A-2hbwA:
undetectable		 4nc3A-2hbwA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 2hbw NLP/P60 PROTEIN
(Trichormus
variabilis) 		5 / 12 LEU A 165
GLY A 178
THR A 104
ILE A 101
LEU A 181
 None
 1.29A 4o5fA-2hbwA:
undetectable
4o5fB-2hbwA:
undetectable		 4o5fA-2hbwA:
23.00
4o5fB-2hbwA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 2hbw NLP/P60 PROTEIN
(Trichormus
variabilis) 		5 / 11 LEU A 219
GLY A 178
LEU A 179
PHE A 167
ALA A 222
 None
 1.36A 4wnuC-2hbwA:
undetectable		 4wnuC-2hbwA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2hbw NLP/P60 PROTEIN
(Trichormus
variabilis) 		4 / 6 ILE A 155
VAL A 166
ASP A 164
ALA A 222
 None
 0.81A 5cu6A-2hbwA:
undetectable		 5cu6A-2hbwA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 2hbw NLP/P60 PROTEIN
(Trichormus
variabilis) 		4 / 7 VAL A 225
THR A 152
LEU A 179
VAL A 177
 None
 1.00A 5e4dA-2hbwA:
undetectable
5e4dB-2hbwA:
undetectable		 5e4dA-2hbwA:
18.88
5e4dB-2hbwA:
18.88