SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hc8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 2hc8 CATION-TRANSPORTING
ATPASE, P-TYPE
(Archaeoglobus
fulgidus) 		4 / 8 ALA A 305
GLY A 292
ILE A 257
VAL A 243
 None
 0.74A 1d4sB-2hc8A:
undetectable		 1d4sB-2hc8A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 2hc8 CATION-TRANSPORTING
ATPASE, P-TYPE
(Archaeoglobus
fulgidus) 		5 / 9 ASP A 288
VAL A 290
ILE A 250
PRO A 258
VAL A 259
 None
 1.03A 1hpvB-2hc8A:
undetectable		 1hpvB-2hc8A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_2
(PROTEASE RETROPEPSIN)		 2hc8 CATION-TRANSPORTING
ATPASE, P-TYPE
(Archaeoglobus
fulgidus) 		5 / 11 ASP A 288
VAL A 290
ILE A 250
PRO A 258
VAL A 259
 None
 0.77A 1t3rB-2hc8A:
undetectable		 1t3rB-2hc8A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2hc8 CATION-TRANSPORTING
ATPASE, P-TYPE
(Archaeoglobus
fulgidus) 		3 / 3 ARG A 252
VAL A 264
GLY A 246
 None
 0.51A 2avvE-2hc8A:
undetectable		 2avvE-2hc8A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_2
(PROTEASE)		 2hc8 CATION-TRANSPORTING
ATPASE, P-TYPE
(Archaeoglobus
fulgidus) 		5 / 12 ASP A 288
VAL A 290
ILE A 250
PRO A 258
VAL A 259
 None
 0.82A 2ienB-2hc8A:
undetectable		 2ienB-2hc8A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 2hc8 CATION-TRANSPORTING
ATPASE, P-TYPE
(Archaeoglobus
fulgidus) 		5 / 12 ASP A 288
VAL A 290
ILE A 250
PRO A 258
VAL A 259
 None
 0.93A 2ieoA-2hc8A:
undetectable		 2ieoA-2hc8A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 2hc8 CATION-TRANSPORTING
ATPASE, P-TYPE
(Archaeoglobus
fulgidus) 		5 / 11 ASP A 288
VAL A 290
ILE A 250
PRO A 258
VAL A 259
 None
 1.03A 2qhcA-2hc8A:
undetectable		 2qhcA-2hc8A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 2hc8 CATION-TRANSPORTING
ATPASE, P-TYPE
(Archaeoglobus
fulgidus) 		5 / 9 ASP A 288
VAL A 290
ILE A 250
PRO A 258
VAL A 259
 None
 0.82A 3ekvB-2hc8A:
undetectable		 3ekvB-2hc8A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 2hc8 CATION-TRANSPORTING
ATPASE, P-TYPE
(Archaeoglobus
fulgidus) 		3 / 3 GLU A 267
GLY A 299
THR A 298
 None
 0.54A 3iazA-2hc8A:
undetectable		 3iazA-2hc8A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_1
(GAG-POL POLYPROTEIN)		 2hc8 CATION-TRANSPORTING
ATPASE, P-TYPE
(Archaeoglobus
fulgidus) 		5 / 12 ASP A 288
VAL A 290
ILE A 250
PRO A 258
VAL A 259
 None
 0.82A 3jvyA-2hc8A:
undetectable		 3jvyA-2hc8A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 2hc8 CATION-TRANSPORTING
ATPASE, P-TYPE
(Archaeoglobus
fulgidus) 		5 / 12 ASP A 288
VAL A 290
ILE A 250
PRO A 258
VAL A 259
 None
 0.81A 3lzuB-2hc8A:
undetectable		 3lzuB-2hc8A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)		 2hc8 CATION-TRANSPORTING
ATPASE, P-TYPE
(Archaeoglobus
fulgidus) 		5 / 8 ASP A 288
VAL A 290
ILE A 250
PRO A 258
VAL A 259
 None
 0.82A 3nu9A-2hc8A:
undetectable		 3nu9A-2hc8A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 2hc8 CATION-TRANSPORTING
ATPASE, P-TYPE
(Archaeoglobus
fulgidus) 		5 / 10 ASP A 288
VAL A 290
ILE A 250
PRO A 258
VAL A 259
 None
 0.91A 3nujA-2hc8A:
undetectable		 3nujA-2hc8A:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 2hc8 CATION-TRANSPORTING
ATPASE, P-TYPE
(Archaeoglobus
fulgidus) 		3 / 3 GLY A 221
ILE A 317
VAL A 318
 None
 0.48A 3nv6A-2hc8A:
undetectable		 3nv6A-2hc8A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_1
(HIV-1 PROTEASE)		 2hc8 CATION-TRANSPORTING
ATPASE, P-TYPE
(Archaeoglobus
fulgidus) 		5 / 11 ASP A 288
VAL A 290
ILE A 250
PRO A 258
VAL A 259
 None
 0.88A 3oy4A-2hc8A:
undetectable		 3oy4A-2hc8A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 2hc8 CATION-TRANSPORTING
ATPASE, P-TYPE
(Archaeoglobus
fulgidus) 		5 / 10 ASP A 288
VAL A 290
ILE A 250
PRO A 258
VAL A 259
 None
 1.02A 4dqcA-2hc8A:
undetectable		 4dqcA-2hc8A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_1
(ASPARTYL PROTEASE)		 2hc8 CATION-TRANSPORTING
ATPASE, P-TYPE
(Archaeoglobus
fulgidus) 		5 / 12 ASP A 288
VAL A 290
ILE A 250
PRO A 258
VAL A 259
 None
 0.88A 4dqfA-2hc8A:
undetectable		 4dqfA-2hc8A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 2hc8 CATION-TRANSPORTING
ATPASE, P-TYPE
(Archaeoglobus
fulgidus) 		4 / 8 ASP A 260
VAL A 249
GLY A 246
ALA A 227
 None
 0.89A 4m48A-2hc8A:
undetectable		 4m48A-2hc8A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 2hc8 CATION-TRANSPORTING
ATPASE, P-TYPE
(Archaeoglobus
fulgidus) 		5 / 10 ASP A 288
VAL A 290
ILE A 250
PRO A 258
VAL A 259
 None
 0.83A 4q1wB-2hc8A:
undetectable		 4q1wB-2hc8A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 2hc8 CATION-TRANSPORTING
ATPASE, P-TYPE
(Archaeoglobus
fulgidus) 		3 / 3 GLY A 310
GLY A 309
GLN A 223
 None
 0.35A 5imsA-2hc8A:
undetectable		 5imsA-2hc8A:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_1
(PROTEASE)		 2hc8 CATION-TRANSPORTING
ATPASE, P-TYPE
(Archaeoglobus
fulgidus) 		5 / 12 ASP A 288
VAL A 290
ILE A 250
PRO A 258
VAL A 259
 None
 0.83A 6dgxB-2hc8A:
undetectable		 6dgxB-2hc8A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_1
(PROTEASE)		 2hc8 CATION-TRANSPORTING
ATPASE, P-TYPE
(Archaeoglobus
fulgidus) 		5 / 12 ASP A 288
VAL A 290
ILE A 250
PRO A 258
VAL A 259
 None
 0.85A 6dh0B-2hc8A:
undetectable		 6dh0B-2hc8A:
21.93