SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hcb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Aquifex
aeolicus) 		4 / 7 GLY A 233
PHE A 199
ILE A 209
PHE A 195
 None
 0.97A 2qmzA-2hcbA:
undetectable
2qmzB-2hcbA:
undetectable		 2qmzA-2hcbA:
22.75
2qmzB-2hcbA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Aquifex
aeolicus) 		4 / 7 GLY A 234
PHE A 199
ILE A 209
PHE A 195
 None
 1.04A 2qmzA-2hcbA:
undetectable
2qmzB-2hcbA:
undetectable		 2qmzA-2hcbA:
22.75
2qmzB-2hcbA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Aquifex
aeolicus) 		5 / 11 ALA A 131
LEU A 178
LEU A 105
ILE A 115
THR A  84
 None
 1.32A 3jw5A-2hcbA:
undetectable		 3jw5A-2hcbA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Aquifex
aeolicus) 		5 / 8 PHE A 167
TYR A 171
ALA A 154
ALA A 152
LEU A 185
 None
 1.14A 3l4dA-2hcbA:
undetectable		 3l4dA-2hcbA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_B_TPFB490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Aquifex
aeolicus) 		5 / 9 PHE A 167
TYR A 171
ALA A 154
ALA A 152
LEU A 185
 None
 1.26A 3l4dB-2hcbA:
undetectable		 3l4dB-2hcbA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Aquifex
aeolicus) 		3 / 3 GLY A 122
GLY A 124
THR A 126
 ACP  A 700 (-3.3A)
ACP  A 700 (-3.1A)
MG  A 400 ( 2.9A)
 0.45A 3si7B-2hcbA:
6.1		 3si7B-2hcbA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Aquifex
aeolicus) 		4 / 7 PHE A 195
PHE A 151
ALA A 148
LEU A 211
 None
 1.09A 3t3sC-2hcbA:
undetectable		 3t3sC-2hcbA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Aquifex
aeolicus) 		4 / 8 ASN A 113
PHE A 195
ILE A 198
PHE A 151
 None
 0.90A 4fglD-2hcbA:
undetectable		 4fglD-2hcbA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Aquifex
aeolicus) 		4 / 7 ASN A 113
PHE A 195
ILE A 198
PHE A 151
 None
 0.91A 4fglC-2hcbA:
undetectable		 4fglC-2hcbA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Aquifex
aeolicus) 		4 / 7 GLY A 234
PHE A 199
ILE A 209
PHE A 195
 None
 0.71A 4fglC-2hcbA:
undetectable		 4fglC-2hcbA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Aquifex
aeolicus) 		3 / 3 HIS A 127
VAL A 143
LEU A  79
 ACP  A 700 (-3.9A)
None
None
 0.62A 4m2vA-2hcbA:
undetectable		 4m2vA-2hcbA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Aquifex
aeolicus) 		4 / 6 GLY A 234
PHE A 199
ILE A 209
PHE A 195
 None
 0.89A 4qogA-2hcbA:
undetectable
4qogB-2hcbA:
undetectable		 4qogA-2hcbA:
22.75
4qogB-2hcbA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Aquifex
aeolicus) 		4 / 8 GLU A 271
LEU A 305
VAL A 320
LEU A 324
 None
 1.01A 4r38B-2hcbA:
undetectable		 4r38B-2hcbA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Aquifex
aeolicus) 		5 / 9 GLU A 271
LEU A 305
VAL A 320
LEU A 324
ILE A 308
 None
 1.33A 4r38C-2hcbA:
undetectable		 4r38C-2hcbA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Aquifex
aeolicus) 		4 / 7 ARG A 139
ALA A 131
ILE A 210
LEU A 178
 None
 0.97A 5te8C-2hcbA:
undetectable		 5te8C-2hcbA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Aquifex
aeolicus) 		5 / 12 LEU A 177
ILE A 144
GLY A 133
LEU A 202
VAL A 174
 None
 0.92A 5twjA-2hcbA:
undetectable		 5twjA-2hcbA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Aquifex
aeolicus) 		5 / 10 LEU A 177
ILE A 144
GLY A 133
LEU A 202
VAL A 174
 None
 0.95A 5twjB-2hcbA:
undetectable		 5twjB-2hcbA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Aquifex
aeolicus) 		5 / 11 LEU A 177
ILE A 144
GLY A 133
LEU A 202
VAL A 174
 None
 0.93A 5twjD-2hcbA:
undetectable		 5twjD-2hcbA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Aquifex
aeolicus) 		4 / 8 VAL A 276
PHE A  88
THR A 245
GLY A 124
 ACP  A 700 (-4.1A)
ACP  A 700 (-3.2A)
None
ACP  A 700 (-3.1A)
 1.00A 5v0vA-2hcbA:
undetectable		 5v0vA-2hcbA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Aquifex
aeolicus) 		5 / 12 SER A 146
TYR A 171
ILE A 198
ALA A 148
LEU A 185
 None
 1.40A 5zwrB-2hcbA:
undetectable		 5zwrB-2hcbA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Aquifex
aeolicus) 		4 / 7 ASP A 303
ARG A 299
GLU A 295
GLU A 271
 None
 1.22A 6mn5B-2hcbA:
undetectable		 6mn5B-2hcbA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Aquifex
aeolicus) 		4 / 6 ASP A 303
ARG A 299
GLU A 295
GLU A 271
 None
 1.12A 6mn5D-2hcbA:
undetectable		 6mn5D-2hcbA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Aquifex
aeolicus) 		4 / 7 ASP A 303
ARG A 299
GLU A 295
GLU A 271
 None
 0.76A 6mn5E-2hcbA:
undetectable		 6mn5E-2hcbA:
11.97