SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hcf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 2hcf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Chlorobaculum
tepidum) 		4 / 7 PHE A   8
VAL A 223
VAL A 173
ILE A 175
 None
 0.84A 1p7rA-2hcfA:
undetectable		 1p7rA-2hcfA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2hcf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Chlorobaculum
tepidum) 		5 / 12 VAL A  56
LEU A  57
SER A  58
GLY A  50
ALA A  51
 None
 1.08A 1pxxC-2hcfA:
undetectable		 1pxxC-2hcfA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 2hcf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Chlorobaculum
tepidum) 		4 / 7 PRO A 130
LEU A 127
GLY A 123
LEU A  15
 None
 0.93A 1ya4B-2hcfA:
2.6		 1ya4B-2hcfA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2hcf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Chlorobaculum
tepidum) 		5 / 12 ASP A   9
GLY A  46
GLY A 117
THR A 178
ASP A  11
 MG  A 300 (-2.5A)
MG  A 300 ( 4.7A)
None
MG  A 300 ( 4.8A)
None
 0.72A 2oxtD-2hcfA:
undetectable		 2oxtD-2hcfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 2hcf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Chlorobaculum
tepidum) 		4 / 8 LEU A 101
LEU A 127
LYS A 128
LEU A  93
 None
 1.19A 2xn3A-2hcfA:
undetectable
2xn3B-2hcfA:
undetectable		 2xn3A-2hcfA:
19.10
2xn3B-2hcfA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2hcf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Chlorobaculum
tepidum) 		6 / 12 ILE A 227
LEU A 111
ALA A 159
VAL A 173
LEU A   7
LEU A 115
 None
 1.48A 2yqzA-2hcfA:
2.9		 2yqzA-2hcfA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2hcf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Chlorobaculum
tepidum) 		6 / 12 ILE A 227
LEU A 111
ALA A 159
VAL A 173
LEU A   7
LEU A 115
 None
 1.50A 2yqzB-2hcfA:
2.7		 2yqzB-2hcfA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAW_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2hcf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Chlorobaculum
tepidum) 		4 / 6 PHE A   8
LEU A 224
VAL A 223
VAL A 173
 None
 1.06A 2zawA-2hcfA:
undetectable		 2zawA-2hcfA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUH_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2hcf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Chlorobaculum
tepidum) 		4 / 6 PHE A   8
LEU A 224
VAL A 223
VAL A 173
 None
 1.09A 2zuhA-2hcfA:
undetectable		 2zuhA-2hcfA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2hcf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Chlorobaculum
tepidum) 		5 / 12 LEU A 112
ILE A 175
ASP A   9
LEU A 101
LEU A 100
 None
None
MG  A 300 (-2.5A)
None
None
 1.00A 3cjtC-2hcfA:
2.8		 3cjtC-2hcfA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 2hcf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Chlorobaculum
tepidum) 		4 / 8 SER A  58
ILE A  52
LEU A  29
ASN A  59
 None
 0.86A 3dcjB-2hcfA:
3.2		 3dcjB-2hcfA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2hcf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Chlorobaculum
tepidum) 		5 / 9 LEU A   5
LEU A 115
ILE A 174
ALA A 190
ALA A 155
 None
 1.12A 3mdvA-2hcfA:
undetectable		 3mdvA-2hcfA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NHX_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 2hcf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Chlorobaculum
tepidum) 		5 / 12 LEU A 146
PHE A 119
PHE A  44
VAL A  56
ALA A  74
 None
 1.44A 3nhxA-2hcfA:
0.0		 3nhxA-2hcfA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 2hcf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Chlorobaculum
tepidum) 		5 / 12 ASP A 177
ILE A 175
ASP A  49
ILE A  52
ASP A   9
 MG  A 300 (-2.7A)
None
None
None
MG  A 300 (-2.5A)
 1.43A 3phaB-2hcfA:
undetectable		 3phaB-2hcfA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 2hcf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Chlorobaculum
tepidum) 		5 / 12 LEU A 100
PHE A   8
TYR A 135
ASP A   9
ASP A 177
 None
None
None
MG  A 300 (-2.5A)
MG  A 300 (-2.7A)
 1.48A 4j7xF-2hcfA:
2.1		 4j7xF-2hcfA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_H_RFPH1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2hcf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Chlorobaculum
tepidum) 		5 / 12 ASP A 102
LEU A 114
ARG A 124
PRO A 130
ARG A  98
 None
 1.37A 4kmuH-2hcfA:
1.1		 4kmuH-2hcfA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2hcf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Chlorobaculum
tepidum) 		4 / 5 PHE A   8
LEU A 224
VAL A 223
VAL A 173
 None
 1.18A 4l49A-2hcfA:
undetectable		 4l49A-2hcfA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2hcf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Chlorobaculum
tepidum) 		5 / 11 ALA A  51
GLU A 179
ASP A   9
THR A  13
GLY A 176
 None
None
MG  A 300 (-2.5A)
None
None
 1.40A 4zjoD-2hcfA:
2.0		 4zjoD-2hcfA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 2hcf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Chlorobaculum
tepidum) 		5 / 12 GLY A  46
GLY A 117
THR A 178
VAL A 195
ASP A  11
 MG  A 300 ( 4.7A)
None
MG  A 300 ( 4.8A)
None
None
 0.94A 5njvC-2hcfA:
undetectable		 5njvC-2hcfA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2hcf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Chlorobaculum
tepidum) 		3 / 3 ARG A  98
PHE A 217
LEU A  93
 None
 0.88A 5x1bC-2hcfA:
undetectable		 5x1bC-2hcfA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2hcf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Chlorobaculum
tepidum) 		4 / 5 LEU A 114
PHE A   8
PHE A 136
LEU A 127
 None
 1.13A 5x1bP-2hcfA:
undetectable		 5x1bP-2hcfA:
21.83