SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hck'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
ALA A 293
THR A 338
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.87A 1iepA-2hckA:
29.9		 1iepA-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
THR A 338
PHE A 340
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.94A 1iepA-2hckA:
29.9		 1iepA-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		4 / 6 LYS A 295
VAL A 323
ILE A 336
MET A 341
 None
 0.89A 1iepA-2hckA:
29.9		 1iepA-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 LEU A 273
ALA A 293
THR A 338
PHE A 340
GLY A 344
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 ( 4.5A)
 0.94A 1iepB-2hckA:
29.9		 1iepB-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 LEU A 273
VAL A 281
ALA A 293
THR A 338
PHE A 340
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 ( 4.5A)
 0.91A 1iepB-2hckA:
29.9		 1iepB-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		4 / 7 LYS A 295
VAL A 323
ILE A 336
MET A 341
 None
 0.64A 1iepB-2hckA:
29.9		 1iepB-2hckA:
30.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
ALA A 293
LYS A 295
THR A 338
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.70A 1m17A-2hckA:
28.3		 1m17A-2hckA:
27.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
THR A 338
PHE A 340
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
 0.67A 1opjA-2hckA:
29.4		 1opjA-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 293
VAL A 323
THR A 338
PHE A 340
GLY A 344
ALA A 403
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 ( 4.5A)
 0.83A 1opjB-2hckA:
29.2		 1opjB-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		4 / 6 LEU A 273
LYS A 295
ILE A 336
MET A 341
 QUE  A   1 (-3.9A)
None
None
None
 0.85A 1opjB-2hckA:
29.2		 1opjB-2hckA:
30.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		4 / 8 GLU A 372
ARG A 175
GLU A 159
ASP A 365
 None
PTR  A 527 ( 3.3A)
None
None
 1.17A 1s3zA-2hckA:
undetectable
1s3zB-2hckA:
undetectable		 1s3zA-2hckA:
15.38
1s3zB-2hckA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 9 LEU A 273
VAL A 281
ALA A 293
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.56A 1xbbA-2hckA:
30.2		 1xbbA-2hckA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 ALA A 293
THR A 338
GLY A 344
LEU A 347
ASP A 348
LEU A 393
ASP A 404
 QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
None
QUE  A   1 ( 4.1A)
QUE  A   1 (-4.4A)
None
 0.76A 1xkkA-2hckA:
31.3		 1xkkA-2hckA:
27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 MET A 314
THR A 338
GLY A 344
LEU A 347
ASP A 348
ASP A 404
 None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
None
QUE  A   1 ( 4.1A)
None
 0.97A 1xkkA-2hckA:
31.3		 1xkkA-2hckA:
27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 9 LEU A 273
VAL A 281
LYS A 295
LEU A 325
MET A 341
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
None
None
None
 0.62A 1xkkA-2hckA:
31.3		 1xkkA-2hckA:
27.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		10 / 12 LEU A 273
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.76A 2gqgA-2hckA:
30.7		 2gqgA-2hckA:
30.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
ILE A 336
THR A 338
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.60A 2gqgB-2hckA:
31.0		 2gqgB-2hckA:
30.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
THR A 338
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.65A 2gqgB-2hckA:
31.0		 2gqgB-2hckA:
30.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 293
THR A 338
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.61A 2hyyA-2hckA:
30.1		 2hyyA-2hckA:
30.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		4 / 6 LEU A 273
LYS A 295
VAL A 323
ILE A 336
 QUE  A   1 (-3.9A)
None
None
None
 0.90A 2hyyA-2hckA:
30.1		 2hyyA-2hckA:
30.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 293
THR A 338
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.56A 2hyyB-2hckA:
30.3		 2hyyB-2hckA:
30.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 6 LEU A 273
LYS A 295
VAL A 323
ILE A 336
MET A 341
 QUE  A   1 (-3.9A)
None
None
None
None
 0.92A 2hyyB-2hckA:
30.3		 2hyyB-2hckA:
30.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 ALA A 293
VAL A 323
THR A 338
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.63A 2hyyC-2hckA:
30.4		 2hyyC-2hckA:
30.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
VAL A 323
THR A 338
PHE A 340
LEU A 393
ALA A 403
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.83A 2hyyC-2hckA:
30.4		 2hyyC-2hckA:
30.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		4 / 6 LEU A 273
LYS A 295
ILE A 336
MET A 341
 QUE  A   1 (-3.9A)
None
None
None
 0.91A 2hyyC-2hckA:
30.4		 2hyyC-2hckA:
30.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
ILE A 336
THR A 338
PHE A 340
LEU A 393
ALA A 403
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.91A 2hyyD-2hckA:
30.2		 2hyyD-2hckA:
30.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		4 / 4 LEU A 273
LYS A 295
VAL A 323
MET A 341
 QUE  A   1 (-3.9A)
None
None
None
 0.87A 2hyyD-2hckA:
30.2		 2hyyD-2hckA:
30.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 293
LYS A 295
THR A 338
GLY A 344
ASP A 348
LEU A 393
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 ( 4.1A)
QUE  A   1 (-4.4A)
 0.71A 2itoA-2hckA:
28.4		 2itoA-2hckA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 LEU A 273
ALA A 293
LYS A 295
THR A 338
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.70A 2itoA-2hckA:
28.4		 2itoA-2hckA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		3 / 3 LEU A 226
TYR A 230
GLY A 233
 None
 0.65A 2ocuA-2hckA:
undetectable		 2ocuA-2hckA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PK4_A_ACAA100_1
(HUMAN PLASMINOGEN
KRINGLE 4)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		4 / 7 LYS A 231
ASP A 228
PHE A 172
TRP A 148
 None
 1.25A 2pk4A-2hckA:
undetectable		 2pk4A-2hckA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 9 LEU A 273
VAL A 281
ALA A 293
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.60A 2xp2A-2hckA:
29.4		 2xp2A-2hckA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 10 VAL A 281
ALA A 293
MET A 341
GLY A 344
ASP A 348
LEU A 393
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
QUE  A   1 ( 4.1A)
QUE  A   1 (-4.4A)
 0.51A 2y7jD-2hckA:
24.2		 2y7jD-2hckA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 8 LEU A 273
ALA A 293
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.53A 2yfxA-2hckA:
28.8		 2yfxA-2hckA:
26.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		10 / 12 LEU A 273
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
MET A 341
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-3.3A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.81A 2zvaA-2hckA:
33.8		 2zvaA-2hckA:
60.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 10 LEU A 273
ALA A 293
VAL A 323
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.62A 3aoxA-2hckA:
28.2		 3aoxA-2hckA:
29.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		9 / 12 VAL A 281
ALA A 293
MET A 314
LEU A 325
THR A 338
GLY A 344
LEU A 393
ASP A 404
PHE A 405
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
None
 0.83A 3bbtB-2hckA:
31.7		 3bbtB-2hckA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 VAL A 281
MET A 314
THR A 338
GLY A 344
LEU A 393
ASP A 404
PHE A 405
LEU A 407
 QUE  A   1 ( 4.8A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
None
None
 1.09A 3bbtB-2hckA:
31.7		 3bbtB-2hckA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 VAL A 281
ALA A 293
LYS A 295
MET A 314
GLY A 344
LEU A 393
ASP A 404
PHE A 405
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
None
 0.82A 3bbtD-2hckA:
32.2		 3bbtD-2hckA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 VAL A 281
ALA A 293
LYS A 295
MET A 314
THR A 338
GLY A 344
LEU A 393
ASP A 404
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
 0.70A 3bbtD-2hckA:
32.2		 3bbtD-2hckA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 VAL A 281
LYS A 295
MET A 314
GLY A 344
LEU A 393
ASP A 404
PHE A 405
LEU A 407
 QUE  A   1 ( 4.8A)
None
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
None
None
 1.13A 3bbtD-2hckA:
32.2		 3bbtD-2hckA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 VAL A 281
LYS A 295
MET A 314
THR A 338
GLY A 344
LEU A 393
ASP A 404
LEU A 407
 QUE  A   1 ( 4.8A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
None
 0.99A 3bbtD-2hckA:
32.2		 3bbtD-2hckA:
25.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
GLY A 274
ALA A 293
LYS A 295
PHE A 340
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.94A 3c7qA-2hckA:
27.5		 3c7qA-2hckA:
34.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
GLY A 274
ALA A 293
VAL A 323
PHE A 340
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.76A 3c7qA-2hckA:
27.5		 3c7qA-2hckA:
34.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 10 LEU A 273
VAL A 281
LYS A 295
VAL A 323
ILE A 336
PHE A 340
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
None
None
None
QUE  A   1 (-4.2A)
 0.71A 3cs9A-2hckA:
30.2		 3cs9A-2hckA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 293
LEU A 322
GLY A 344
HIS A 384
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.45A 3cs9A-2hckA:
30.2		 3cs9A-2hckA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 293
LEU A 322
THR A 338
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.58A 3cs9A-2hckA:
30.2		 3cs9A-2hckA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 12 ALA A 293
LEU A 322
GLY A 344
HIS A 384
ALA A 403
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
None
QUE  A   1 ( 4.5A)
 0.42A 3cs9B-2hckA:
30.5		 3cs9B-2hckA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 9 LEU A 273
VAL A 281
LYS A 295
VAL A 323
ILE A 336
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
None
None
None
 0.68A 3cs9B-2hckA:
30.5		 3cs9B-2hckA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 9 LEU A 273
VAL A 281
VAL A 323
ILE A 336
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
None
None
QUE  A   1 (-4.4A)
 0.82A 3cs9B-2hckA:
30.5		 3cs9B-2hckA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 293
LEU A 322
THR A 338
PHE A 340
HIS A 384
ALA A 403
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
None
QUE  A   1 ( 4.5A)
 0.74A 3cs9C-2hckA:
30.1		 3cs9C-2hckA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 9 LEU A 273
VAL A 281
LYS A 295
VAL A 323
ILE A 336
MET A 341
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
None
None
None
None
 0.79A 3cs9C-2hckA:
30.1		 3cs9C-2hckA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 293
LEU A 322
PHE A 340
GLY A 344
HIS A 384
ALA A 403
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
None
QUE  A   1 ( 4.5A)
 0.38A 3cs9D-2hckA:
29.0		 3cs9D-2hckA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 293
LEU A 322
THR A 338
PHE A 340
GLY A 344
HIS A 384
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
None
 0.51A 3cs9D-2hckA:
29.0		 3cs9D-2hckA:
30.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		10 / 12 LEU A 273
GLY A 274
GLY A 276
GLY A 279
VAL A 281
ALA A 293
LYS A 295
SER A 345
ASN A 391
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
None
None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 ( 4.7A)
None
QUE  A   1 (-4.4A)
 0.90A 3eygA-2hckA:
28.1		 3eygA-2hckA:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
GLY A 274
GLY A 276
GLY A 279
VAL A 281
ALA A 293
LYS A 295
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
None
None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.4A)
 0.76A 3fupA-2hckA:
28.7		 3fupA-2hckA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
GLY A 274
GLY A 276
GLY A 279
VAL A 281
ALA A 293
SER A 345
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
None
None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 ( 4.7A)
QUE  A   1 (-4.4A)
 0.73A 3fupA-2hckA:
28.7		 3fupA-2hckA:
26.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
ILE A 336
THR A 338
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.56A 3g5dA-2hckA:
32.4		 3g5dA-2hckA:
50.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
THR A 338
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.64A 3g5dA-2hckA:
32.4		 3g5dA-2hckA:
50.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
THR A 338
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.78A 3g5dB-2hckA:
32.6		 3g5dB-2hckA:
50.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
THR A 338
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.82A 3gvuA-2hckA:
30.5		 3gvuA-2hckA:
31.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 293
LEU A 322
VAL A 323
HIS A 384
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.57A 3ik3A-2hckA:
30.0		 3ik3A-2hckA:
31.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 293
LEU A 322
VAL A 323
HIS A 384
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.64A 3ik3B-2hckA:
29.8		 3ik3B-2hckA:
31.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		4 / 7 LEU A 273
LYS A 295
ILE A 336
MET A 341
 QUE  A   1 (-3.9A)
None
None
None
 0.85A 3ik3B-2hckA:
29.8		 3ik3B-2hckA:
31.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.78A 3k54A-2hckA:
30.3		 3k54A-2hckA:
28.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 293
THR A 338
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.63A 3k5vA-2hckA:
29.4		 3k5vA-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 6 LEU A 273
LYS A 295
VAL A 323
ILE A 336
MET A 341
 QUE  A   1 (-3.9A)
None
None
None
None
 0.86A 3k5vA-2hckA:
29.4		 3k5vA-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 293
THR A 338
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.59A 3k5vB-2hckA:
29.5		 3k5vB-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		4 / 6 LEU A 273
LYS A 295
VAL A 323
ILE A 336
 QUE  A   1 (-3.9A)
None
None
None
 0.86A 3k5vB-2hckA:
29.5		 3k5vB-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		4 / 6 LEU A 273
VAL A 323
ILE A 336
MET A 341
 QUE  A   1 (-3.9A)
None
None
None
 0.69A 3k5vB-2hckA:
29.5		 3k5vB-2hckA:
30.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
GLY A 274
GLY A 276
VAL A 281
ALA A 293
SER A 345
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 ( 4.7A)
QUE  A   1 (-4.4A)
 0.69A 3lxnA-2hckA:
27.9		 3lxnA-2hckA:
27.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 11 ALA A 293
VAL A 323
PHE A 340
MET A 341
GLY A 344
LEU A 393
ASP A 404
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.2A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
 0.55A 3miyA-2hckA:
31.4		 3miyA-2hckA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 9 ALA A 293
PHE A 340
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.5A)
QUE  A   1 (-4.2A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.35A 3miyB-2hckA:
31.4		 3miyB-2hckA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
THR A 338
PHE A 340
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.88A 3ms9A-2hckA:
29.7		 3ms9A-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		4 / 6 LYS A 295
VAL A 323
ILE A 336
MET A 341
 None
 0.86A 3ms9A-2hckA:
29.7		 3ms9A-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
ALA A 293
THR A 338
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.83A 3ms9B-2hckA:
29.9		 3ms9B-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
THR A 338
PHE A 340
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.90A 3ms9B-2hckA:
29.9		 3ms9B-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
THR A 338
PHE A 340
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.92A 3mssA-2hckA:
29.9		 3mssA-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		4 / 6 LYS A 295
VAL A 323
ILE A 336
MET A 341
 None
 0.87A 3mssA-2hckA:
29.9		 3mssA-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 293
THR A 338
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.59A 3mssB-2hckA:
30.1		 3mssB-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		4 / 7 LYS A 295
VAL A 323
ILE A 336
MET A 341
 None
 0.95A 3mssB-2hckA:
30.1		 3mssB-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
THR A 338
PHE A 340
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.91A 3mssC-2hckA:
29.8		 3mssC-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		4 / 6 LYS A 295
VAL A 323
ILE A 336
MET A 341
 None
 0.89A 3mssC-2hckA:
29.8		 3mssC-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
ALA A 293
THR A 338
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.87A 3mssD-2hckA:
30.1		 3mssD-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 6 VAL A 281
LYS A 295
VAL A 323
ILE A 336
MET A 341
 QUE  A   1 ( 4.8A)
None
None
None
None
 0.90A 3mssD-2hckA:
30.1		 3mssD-2hckA:
30.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
THR A 338
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.74A 3octA-2hckA:
29.8		 3octA-2hckA:
26.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
LYS A 295
ILE A 336
THR A 338
LEU A 393
ALA A 403
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.74A 3oezB-2hckA:
32.7		 3oezB-2hckA:
50.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 ALA A 293
LEU A 322
VAL A 323
THR A 338
GLY A 344
HIS A 384
ALA A 403
 QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
None
QUE  A   1 ( 4.5A)
 0.65A 3oxzA-2hckA:
30.2		 3oxzA-2hckA:
32.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 9 LEU A 273
LYS A 295
ILE A 336
MET A 341
LEU A 393
 QUE  A   1 (-3.9A)
None
None
None
QUE  A   1 (-4.4A)
 0.76A 3oxzA-2hckA:
30.1		 3oxzA-2hckA:
32.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
THR A 338
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.89A 3pyyB-2hckA:
30.1		 3pyyB-2hckA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
THR A 338
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.87A 3qlgA-2hckA:
32.8		 3qlgA-2hckA:
50.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
THR A 338
GLY A 344
LEU A 393
ALA A 403
ASP A 404
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
None
 0.74A 3qlgB-2hckA:
32.6		 3qlgB-2hckA:
50.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		4 / 4 LYS A 295
ILE A 336
MET A 341
LYS A 343
 None
 1.09A 3qlgB-2hckA:
32.6		 3qlgB-2hckA:
50.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
ILE A 336
THR A 338
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.61A 3sxrA-2hckA:
30.6		 3sxrA-2hckA:
32.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
THR A 338
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.64A 3sxrB-2hckA:
30.2		 3sxrB-2hckA:
32.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		10 / 12 LEU A 273
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
PHE A 340
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.60A 3ue4A-2hckA:
31.1		 3ue4A-2hckA:
33.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
ILE A 336
THR A 338
PHE A 340
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.62A 3ue4B-2hckA:
30.7		 3ue4B-2hckA:
33.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.82A 3ug2A-2hckA:
27.9		 3ug2A-2hckA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 GLY A 276
GLY A 279
VAL A 281
ALA A 293
VAL A 323
LEU A 393
ASP A 404
 None
None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.4A)
None
 1.02A 3v5wA-2hckA:
8.6		 3v5wA-2hckA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		4 / 8 TYR A 479
TRP A 499
ARG A 483
MET A 495
 None
 1.27A 3wipB-2hckA:
undetectable
3wipC-2hckA:
undetectable		 3wipB-2hckA:
20.18
3wipC-2hckA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_C_ACHC301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		4 / 8 TYR A 479
TRP A 499
ARG A 483
MET A 495
 None
 1.36A 3wipC-2hckA:
undetectable
3wipD-2hckA:
undetectable		 3wipC-2hckA:
20.18
3wipD-2hckA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_E_ACHE301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		4 / 8 TRP A 499
ARG A 483
MET A 495
TYR A 479
 None
 1.29A 3wipA-2hckA:
undetectable
3wipE-2hckA:
undetectable		 3wipA-2hckA:
20.18
3wipE-2hckA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 12 LEU A 273
ALA A 293
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.51A 3zbfA-2hckA:
29.1		 3zbfA-2hckA:
28.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
PHE A 340
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.76A 4ag8A-2hckA:
28.7		 4ag8A-2hckA:
28.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 11 LEU A 273
ALA A 293
VAL A 323
PHE A 340
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.58A 4agdA-2hckA:
27.8		 4agdA-2hckA:
30.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LYS A 295
LEU A 325
ILE A 336
ASP A 386
ASN A 391
ASP A 404
GLY A 406
 None
 1.02A 4an2A-2hckA:
26.3		 4an2A-2hckA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 9 LEU A 273
VAL A 281
ALA A 293
MET A 341
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.78A 4anqA-2hckA:
29.0		 4anqA-2hckA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 9 LEU A 273
VAL A 281
ALA A 293
MET A 341
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.79A 4ansA-2hckA:
28.9		 4ansA-2hckA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 ALA A 293
LYS A 295
ILE A 336
THR A 338
HIS A 384
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.91A 4c8bA-2hckA:
25.6		 4c8bA-2hckA:
22.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 11 LEU A 273
GLY A 274
GLY A 276
VAL A 281
ALA A 293
GLY A 344
SER A 345
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.0A)
QUE  A   1 ( 4.7A)
 0.73A 4ckiA-2hckA:
30.1		 4ckiA-2hckA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 11 LEU A 273
GLY A 274
VAL A 281
ALA A 293
GLY A 344
SER A 345
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.0A)
QUE  A   1 ( 4.7A)
QUE  A   1 (-4.4A)
 0.46A 4ckiA-2hckA:
30.1		 4ckiA-2hckA:
33.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
THR A 338
MET A 341
GLY A 344
LEU A 393
ASP A 404
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
 0.60A 4hjoA-2hckA:
32.7		 4hjoA-2hckA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
GLY A 274
VAL A 281
ALA A 293
LYS A 295
ASP A 348
LEU A 393
ASP A 404
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 ( 4.1A)
QUE  A   1 (-4.4A)
None
 0.69A 4i22A-2hckA:
30.8		 4i22A-2hckA:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
GLY A 274
VAL A 281
ALA A 293
LYS A 295
GLY A 344
ASP A 348
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
QUE  A   1 ( 4.1A)
QUE  A   1 (-4.4A)
 0.52A 4i22A-2hckA:
30.8		 4i22A-2hckA:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 10 ALA A 293
VAL A 323
PHE A 340
GLY A 344
LEU A 393
ASP A 404
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
 0.68A 4ks8A-2hckA:
19.7		 4ks8A-2hckA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 8 GLY A 276
VAL A 281
ALA A 293
MET A 341
LEU A 393
 None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.4A)
 0.85A 4l9iB-2hckA:
20.7		 4l9iB-2hckA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LYS A 295
LEU A 325
ILE A 336
ASN A 391
ASP A 404
PHE A 405
GLY A 406
 None
 0.95A 4lmnA-2hckA:
25.0		 4lmnA-2hckA:
22.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
GLY A 344
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
 0.66A 4mxoA-2hckA:
32.5		 4mxoA-2hckA:
51.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.63A 4mxoB-2hckA:
32.5		 4mxoB-2hckA:
51.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.64A 4mxxA-2hckA:
32.5		 4mxxA-2hckA:
50.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
THR A 338
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.60A 4mxxB-2hckA:
32.5		 4mxxB-2hckA:
50.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.76A 4mxyB-2hckA:
32.8		 4mxyB-2hckA:
50.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.76A 4mxzB-2hckA:
32.8		 4mxzB-2hckA:
50.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 11 LEU A 273
GLY A 274
VAL A 281
ALA A 293
ASN A 391
LEU A 393
ASP A 404
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.4A)
None
 0.95A 4o0sA-2hckA:
25.2		 4o0sA-2hckA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
GLY A 276
GLY A 279
VAL A 281
ALA A 293
VAL A 323
ALA A 403
ASP A 404
 QUE  A   1 (-3.9A)
None
None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 ( 4.5A)
None
 0.84A 4otiA-2hckA:
20.2		 4otiA-2hckA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
GLY A 276
GLY A 279
VAL A 281
ALA A 293
VAL A 323
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
None
None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.82A 4otiA-2hckA:
20.2		 4otiA-2hckA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
VAL A 281
LYS A 295
VAL A 323
THR A 338
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.71A 4otwA-2hckA:
31.0		 4otwA-2hckA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 12 LEU A 516
VAL A 456
LEU A 360
ILE A 455
CYH A 487
 None
 1.05A 4p65F-2hckA:
undetectable
4p65H-2hckA:
undetectable
4p65K-2hckA:
undetectable
4p65L-2hckA:
undetectable		 4p65F-2hckA:
5.84
4p65H-2hckA:
5.84
4p65K-2hckA:
4.39
4p65L-2hckA:
5.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		4 / 8 LEU A 273
VAL A 281
HIS A 384
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
None
QUE  A   1 (-4.4A)
 0.61A 4qrcA-2hckA:
29.6		 4qrcA-2hckA:
30.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 12 ALA A 293
ILE A 336
THR A 338
SER A 345
PHE A 405
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 ( 4.7A)
None
 0.75A 4rzvA-2hckA:
11.3		 4rzvA-2hckA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 12 VAL A 281
ALA A 293
THR A 338
SER A 345
PHE A 405
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 ( 4.7A)
None
 0.78A 4rzvB-2hckA:
28.1		 4rzvB-2hckA:
23.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
ALA A 293
PHE A 340
MET A 341
GLY A 344
ASN A 391
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
QUE  A   1 (-4.2A)
None
QUE  A   1 (-3.0A)
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.63A 4twpA-2hckA:
30.7		 4twpA-2hckA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
PHE A 340
MET A 341
ASN A 391
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-4.2A)
None
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.77A 4twpA-2hckA:
30.7		 4twpA-2hckA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
PHE A 340
MET A 341
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.2A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.97A 4twpB-2hckA:
30.8		 4twpB-2hckA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
PHE A 340
MET A 341
GLY A 344
ASN A 391
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-4.2A)
None
QUE  A   1 (-3.0A)
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.75A 4twpB-2hckA:
30.8		 4twpB-2hckA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		9 / 11 LEU A 273
GLY A 276
VAL A 281
ALA A 293
MET A 341
GLY A 344
ASN A 391
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.64A 4u5jA-2hckA:
33.6		 4u5jA-2hckA:
51.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		9 / 11 LEU A 273
GLY A 279
VAL A 281
ALA A 293
MET A 341
GLY A 344
ASN A 391
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 1.16A 4u5jA-2hckA:
33.6		 4u5jA-2hckA:
51.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 9 LEU A 273
VAL A 281
ALA A 293
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.52A 4u5jB-2hckA:
33.1		 4u5jB-2hckA:
51.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 12 LEU A 273
ALA A 293
HIS A 384
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.50A 4uxqA-2hckA:
29.7		 4uxqA-2hckA:
35.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 10 LEU A 273
VAL A 281
LYS A 295
LEU A 393
ILE A 402
LEU A 407
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
None
QUE  A   1 (-4.4A)
None
None
 1.05A 4v04B-2hckA:
29.1		 4v04B-2hckA:
28.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 11 ALA A 293
THR A 338
MET A 341
GLY A 344
ASN A 391
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
None
QUE  A   1 (-3.0A)
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.51A 4wa9A-2hckA:
28.2		 4wa9A-2hckA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 11 LEU A 273
ALA A 293
LYS A 295
THR A 338
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.71A 4wa9A-2hckA:
28.2		 4wa9A-2hckA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 11 LEU A 273
ALA A 293
THR A 338
MET A 341
GLY A 344
ASN A 391
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
None
QUE  A   1 (-3.0A)
None
QUE  A   1 (-4.4A)
 0.65A 4wa9A-2hckA:
28.2		 4wa9A-2hckA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 ALA A 293
THR A 338
PHE A 340
MET A 341
GLY A 344
ASN A 391
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
None
QUE  A   1 (-3.0A)
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.58A 4wa9B-2hckA:
30.4		 4wa9B-2hckA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 VAL A 281
ALA A 293
LYS A 295
THR A 338
PHE A 340
MET A 341
LEU A 393
ALA A 403
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 1.17A 4wa9B-2hckA:
30.4		 4wa9B-2hckA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 VAL A 281
ALA A 293
THR A 338
PHE A 340
MET A 341
ASN A 391
LEU A 393
ALA A 403
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
None
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.85A 4wa9B-2hckA:
30.4		 4wa9B-2hckA:
33.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		4 / 6 LEU A 273
ALA A 293
MET A 341
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.4A)
 0.71A 4wboC-2hckA:
20.6		 4wboC-2hckA:
25.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		11 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.69A 4xeyA-2hckA:
30.9		 4xeyA-2hckA:
40.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		10 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
ILE A 336
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.67A 4xeyB-2hckA:
30.5		 4xeyB-2hckA:
40.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		10 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
PHE A 340
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.57A 4xeyB-2hckA:
30.5		 4xeyB-2hckA:
40.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 273
ALA A 293
LYS A 295
VAL A 323
THR A 338
MET A 341
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.73A 4xliA-2hckA:
30.7		 4xliA-2hckA:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 273
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.83A 4xliB-2hckA:
30.6		 4xliB-2hckA:
33.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 8 LEU A 273
GLY A 274
VAL A 281
ALA A 293
MET A 341
GLY A 344
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
 0.64A 4zauA-2hckA:
28.6		 4zauA-2hckA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 9 LEU A 273
VAL A 281
ALA A 293
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.58A 5aaaA-2hckA:
29.5		 5aaaA-2hckA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 10 LEU A 273
VAL A 281
ALA A 293
LYS A 295
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.64A 5aabA-2hckA:
29.2		 5aabA-2hckA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 10 LEU A 273
VAL A 281
ALA A 293
LYS A 295
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.61A 5aacA-2hckA:
29.0		 5aacA-2hckA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
ALA A 293
LYS A 295
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.85A 5ajqA-2hckA:
24.3		 5ajqA-2hckA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
GLY A 274
ALA A 293
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
QUE  A   1 (-3.5A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.85A 5ajqA-2hckA:
24.3		 5ajqA-2hckA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 10 ALA A 293
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.40A 5ajqB-2hckA:
23.6		 5ajqB-2hckA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 LEU A 273
VAL A 281
ALA A 293
THR A 338
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.57A 5h2uA-2hckA:
33.8		 5h2uA-2hckA:
29.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		3 / 3 ILE A 336
MET A 341
ASP A 404
 None
 0.66A 5h2uA-2hckA:
33.8		 5h2uA-2hckA:
29.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
ILE A 336
THR A 338
GLY A 344
LEU A 393
ASP A 404
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
 0.71A 5h2uB-2hckA:
33.7		 5h2uB-2hckA:
29.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 LEU A 273
ALA A 293
ILE A 336
GLY A 344
LEU A 393
ASP A 404
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
 0.69A 5h2uC-2hckA:
28.3		 5h2uC-2hckA:
29.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 LEU A 273
ALA A 293
THR A 338
GLY A 344
LEU A 393
ASP A 404
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
 0.67A 5h2uC-2hckA:
28.3		 5h2uC-2hckA:
29.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 LEU A 273
VAL A 281
ALA A 293
ILE A 336
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.53A 5h2uD-2hckA:
33.8		 5h2uD-2hckA:
29.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 LEU A 273
VAL A 281
ALA A 293
THR A 338
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.59A 5h2uD-2hckA:
33.8		 5h2uD-2hckA:
29.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 VAL A 281
ALA A 293
ILE A 336
THR A 338
ASP A 348
PHE A 405
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 ( 4.1A)
None
 0.84A 5hesA-2hckA:
10.7		 5hesA-2hckA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 GLY A 276
VAL A 281
ALA A 293
LYS A 295
ILE A 336
THR A 338
 None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
 0.91A 5hieA-2hckA:
27.0		 5hieA-2hckA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 GLY A 276
VAL A 281
ALA A 293
LYS A 295
ILE A 336
THR A 338
 None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
 0.90A 5hieB-2hckA:
27.0		 5hieB-2hckA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 GLY A 274
GLY A 276
VAL A 281
ALA A 293
LYS A 295
THR A 338
 QUE  A   1 ( 4.2A)
None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
 0.94A 5hieC-2hckA:
26.8		 5hieC-2hckA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 GLY A 276
VAL A 281
ALA A 293
LYS A 295
ILE A 336
THR A 338
 None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
 0.90A 5hieD-2hckA:
26.6		 5hieD-2hckA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 12 ILE A 392
ILE A 370
PHE A 448
ASP A 365
ILE A 455
 None
 1.09A 5lg3E-2hckA:
undetectable		 5lg3E-2hckA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 10 ILE A 392
ILE A 370
PHE A 448
ASP A 365
ILE A 455
 None
 1.08A 5lg3G-2hckA:
undetectable		 5lg3G-2hckA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 12 ILE A 392
ILE A 370
PHE A 448
ASP A 365
ILE A 455
 None
 1.08A 5lg3J-2hckA:
undetectable		 5lg3J-2hckA:
20.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 10 LEU A 273
VAL A 281
LYS A 295
ILE A 336
PHE A 340
MET A 341
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
None
None
QUE  A   1 (-4.2A)
None
 0.84A 5mo4A-2hckA:
37.5		 5mo4A-2hckA:
38.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 293
LEU A 322
VAL A 323
HIS A 384
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.53A 5mo4A-2hckA:
37.5		 5mo4A-2hckA:
38.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 VAL A 281
ALA A 293
LYS A 295
MET A 314
ILE A 336
THR A 338
GLY A 344
PHE A 405
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
None
 0.90A 5p9iA-2hckA:
33.4		 5p9iA-2hckA:
26.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 VAL A 281
ALA A 293
MET A 314
ILE A 336
THR A 338
GLY A 344
LEU A 393
PHE A 405
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
 0.74A 5p9iA-2hckA:
33.4		 5p9iA-2hckA:
26.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 12 ALA A 433
GLY A 437
SER A 438
LEU A 475
TRP A 446
 None
 1.02A 5w7pA-2hckA:
undetectable		 5w7pA-2hckA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 12 LEU A 273
GLY A 274
VAL A 281
ALA A 293
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 ( 4.5A)
 0.63A 5xv7A-2hckA:
20.3		 5xv7A-2hckA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 12 LEU A 273
GLY A 274
VAL A 281
GLY A 344
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.0A)
QUE  A   1 ( 4.5A)
 0.76A 5xv7A-2hckA:
20.3		 5xv7A-2hckA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
GLY A 274
VAL A 281
ALA A 293
LYS A 295
MET A 314
LEU A 393
ASP A 404
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-4.4A)
None
 0.86A 5yu9A-2hckA:
30.9		 5yu9A-2hckA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 GLY A 274
VAL A 281
ALA A 293
LYS A 295
MET A 314
ASP A 348
LEU A 393
ASP A 404
 QUE  A   1 ( 4.2A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 ( 4.1A)
QUE  A   1 (-4.4A)
None
 0.92A 5yu9B-2hckA:
30.9		 5yu9B-2hckA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
LYS A 295
MET A 314
GLY A 344
ASP A 348
ASP A 404
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.0A)
QUE  A   1 ( 4.1A)
None
 0.98A 5yu9C-2hckA:
30.2		 5yu9C-2hckA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 293
LYS A 295
MET A 314
GLY A 344
ASP A 348
ASP A 404
 QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.0A)
QUE  A   1 ( 4.1A)
None
 1.07A 5yu9D-2hckA:
30.6		 5yu9D-2hckA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 293
MET A 314
GLY A 344
ASP A 348
LEU A 393
ASP A 404
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
QUE  A   1 ( 4.1A)
QUE  A   1 (-4.4A)
None
 0.81A 5yu9D-2hckA:
30.6		 5yu9D-2hckA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 VAL A 281
ALA A 293
LYS A 295
MET A 314
GLY A 344
ASP A 404
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.0A)
None
 0.98A 5yu9D-2hckA:
30.6		 5yu9D-2hckA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 VAL A 281
ALA A 293
MET A 314
GLY A 344
LEU A 393
ASP A 404
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
 0.74A 5yu9D-2hckA:
30.6		 5yu9D-2hckA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		4 / 6 SER A 266
TYR A 286
GLU A 255
THR A 290
 None
 1.40A 6djzA-2hckA:
undetectable		 6djzA-2hckA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_1
(GLUCOAMYLASE P)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 12 ALA A 474
TYR A 479
TRP A 499
GLY A 449
ARG A 460
 None
 1.26A 6fhwA-2hckA:
undetectable		 6fhwA-2hckA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_B_ACRB801_1
(GLUCOAMYLASE P)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 12 ALA A 474
TYR A 479
TRP A 499
GLY A 449
ARG A 460
 None
 1.26A 6fhwB-2hckA:
undetectable		 6fhwB-2hckA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNM_A_1N1A1001_1
(-)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
ILE A 336
THR A 338
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.51A 6fnmA-2hckA:
30.4		 6fnmA-2hckA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNM_A_1N1A1001_1
(-)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
LYS A 295
ILE A 336
THR A 338
GLY A 344
LEU A 393
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.76A 6fnmA-2hckA:
30.4		 6fnmA-2hckA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
ALA A 403
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-3.3A)
QUE  A   1 ( 4.5A)
 0.95A 6hd4A-2hckA:
29.2		 6hd4A-2hckA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
VAL A 323
ILE A 336
THR A 338
LEU A 393
ALA A 403
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.95A 6hd4A-2hckA:
29.2		 6hd4A-2hckA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
VAL A 323
ILE A 336
THR A 338
LEU A 393
ALA A 403
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.93A 6hd4B-2hckA:
29.4		 6hd4B-2hckA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		4 / 6 LEU A 273
PHE A 340
MET A 341
GLY A 344
 QUE  A   1 (-3.9A)
QUE  A   1 (-4.2A)
None
QUE  A   1 (-3.0A)
 0.75A 6hd4B-2hckA:
29.4		 6hd4B-2hckA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
PHE A 340
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
 0.67A 6hd6A-2hckA:
29.3		 6hd6A-2hckA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
LYS A 295
VAL A 323
THR A 338
PHE A 340
ALA A 403
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 ( 4.5A)
 0.92A 6hd6A-2hckA:
29.3		 6hd6A-2hckA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
VAL A 323
ILE A 336
THR A 338
PHE A 340
LEU A 393
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-4.4A)
 0.81A 6hd6A-2hckA:
29.3		 6hd6A-2hckA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
VAL A 323
THR A 338
PHE A 340
LEU A 393
ALA A 403
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.90A 6hd6A-2hckA:
29.3		 6hd6A-2hckA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
THR A 338
PHE A 340
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
 0.76A 6hd6B-2hckA:
29.4		 6hd6B-2hckA:
13.06