SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hcm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2hcm DUAL SPECIFICITY
PROTEIN PHOSPHATASE
(Mus
musculus) 		4 / 6 ASN A  97
ASN A  22
ILE A  20
GLY A  21
 None
 1.08A 1oniA-2hcmA:
undetectable
1oniB-2hcmA:
undetectable		 1oniA-2hcmA:
21.56
1oniB-2hcmA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2hcm DUAL SPECIFICITY
PROTEIN PHOSPHATASE
(Mus
musculus) 		4 / 6 ASN A  97
ASN A  22
ILE A  20
GLY A  21
 None
 1.11A 1oniD-2hcmA:
undetectable
1oniF-2hcmA:
undetectable		 1oniD-2hcmA:
21.56
1oniF-2hcmA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 2hcm DUAL SPECIFICITY
PROTEIN PHOSPHATASE
(Mus
musculus) 		4 / 5 ALA A 104
GLY A  98
CYH A  95
LYS A  96
 None
None
None
ZN  A 368 (-4.0A)
 1.25A 2ylgA-2hcmA:
undetectable		 2ylgA-2hcmA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 2hcm DUAL SPECIFICITY
PROTEIN PHOSPHATASE
(Mus
musculus) 		4 / 4 LEU A 142
ALA A 103
PHE A 122
ASN A 135
 None
None
GOL  A 369 (-4.0A)
None
 1.50A 3vaqA-2hcmA:
undetectable		 3vaqA-2hcmA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 2hcm DUAL SPECIFICITY
PROTEIN PHOSPHATASE
(Mus
musculus) 		4 / 5 ALA A 104
GLY A  98
CYH A  95
LYS A  96
 None
None
None
ZN  A 368 (-4.0A)
 1.28A 5jliA-2hcmA:
undetectable		 5jliA-2hcmA:
23.90