SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hcs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)
(West
Nile
virus) 		5 / 12 GLY A 507
HIS A 803
TYR A 610
LEU A 387
LEU A 517
 None
 1.29A 1fm6D-2hcsA:
0.0		 1fm6D-2hcsA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)
(West
Nile
virus) 		4 / 5 SER A 682
THR A 681
GLU A 627
GLY A 630
 None
 1.27A 1icrA-2hcsA:
undetectable
1icrB-2hcsA:
undetectable		 1icrA-2hcsA:
15.67
1icrB-2hcsA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)
(West
Nile
virus) 		4 / 5 GLU A 627
GLY A 630
SER A 682
THR A 681
 None
 1.27A 1icrA-2hcsA:
undetectable
1icrB-2hcsA:
undetectable		 1icrA-2hcsA:
15.67
1icrB-2hcsA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)
(West
Nile
virus) 		4 / 5 SER A 682
THR A 681
GLU A 627
GLY A 630
 None
 1.24A 1icvC-2hcsA:
undetectable
1icvD-2hcsA:
undetectable		 1icvC-2hcsA:
15.67
1icvD-2hcsA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)
(West
Nile
virus) 		4 / 5 GLU A 627
GLY A 630
SER A 682
THR A 681
 None
 1.25A 1icvC-2hcsA:
undetectable
1icvD-2hcsA:
undetectable		 1icvC-2hcsA:
15.67
1icvD-2hcsA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)
(West
Nile
virus) 		4 / 7 VAL A 620
LEU A 376
THR A 380
LEU A 383
 None
 0.76A 1jgsA-2hcsA:
2.0		 1jgsA-2hcsA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)
(West
Nile
virus) 		4 / 5 GLU A 627
GLY A 630
SER A 682
THR A 681
 None
 1.26A 1kqbA-2hcsA:
undetectable
1kqbB-2hcsA:
undetectable		 1kqbA-2hcsA:
16.44
1kqbB-2hcsA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)
(West
Nile
virus) 		3 / 3 PHE A 685
ARG A 543
ASN A 687
 None
 0.86A 1xzxX-2hcsA:
undetectable		 1xzxX-2hcsA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)
(West
Nile
virus) 		4 / 5 LEU A 521
GLY A 511
ALA A 664
ILE A 520
 None
 0.85A 2aohB-2hcsA:
undetectable		 2aohB-2hcsA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)
(West
Nile
virus) 		3 / 3 ARG A 328
VAL A 753
GLY A 880
 None
 0.62A 2avvE-2hcsA:
undetectable		 2avvE-2hcsA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)
(West
Nile
virus) 		3 / 3 PHE A 401
VAL A 428
TRP A 434
 None
 0.86A 2cc8A-2hcsA:
undetectable		 2cc8A-2hcsA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)
(West
Nile
virus) 		3 / 3 PHE A 485
VAL A 437
TRP A 434
 None
 0.80A 2cc8A-2hcsA:
undetectable		 2cc8A-2hcsA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)
(West
Nile
virus) 		3 / 3 PHE A 401
VAL A 428
TRP A 434
 None
 0.88A 2ccbA-2hcsA:
0.4		 2ccbA-2hcsA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)
(West
Nile
virus) 		3 / 3 PHE A 485
VAL A 437
TRP A 434
 None
 0.79A 2ccbA-2hcsA:
0.4		 2ccbA-2hcsA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)
(West
Nile
virus) 		3 / 3 PHE A 401
VAL A 428
TRP A 434
 None
 0.86A 2vx9A-2hcsA:
undetectable		 2vx9A-2hcsA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)
(West
Nile
virus) 		3 / 3 PHE A 485
VAL A 437
TRP A 434
 None
 0.79A 2vx9A-2hcsA:
undetectable		 2vx9A-2hcsA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)
(West
Nile
virus) 		5 / 9 ASP A 541
ASN A 613
GLY A 667
ASP A 668
ASP A 669
 None
 0.80A 3sfuA-2hcsA:
16.7		 3sfuA-2hcsA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		 2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)
(West
Nile
virus) 		5 / 9 ASP A 541
ASN A 613
GLY A 667
ASP A 668
ASP A 669
 None
 0.77A 3sfuB-2hcsA:
16.9		 3sfuB-2hcsA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)
(West
Nile
virus) 		4 / 8 ASP A 669
VAL A 509
PHE A 718
LEU A 514
 None
 1.02A 4f8hA-2hcsA:
undetectable
4f8hB-2hcsA:
undetectable		 4f8hA-2hcsA:
22.20
4f8hB-2hcsA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)
(West
Nile
virus) 		4 / 8 ASP A 669
VAL A 509
PHE A 718
LEU A 514
 None
 1.07A 4f8hB-2hcsA:
undetectable
4f8hC-2hcsA:
undetectable		 4f8hB-2hcsA:
22.20
4f8hC-2hcsA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)
(West
Nile
virus) 		4 / 4 TYR A 610
THR A 614
GLY A 508
LEU A 512
 None
 1.47A 4w5nA-2hcsA:
undetectable		 4w5nA-2hcsA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)
(West
Nile
virus) 		3 / 3 ASN A 782
SER A 890
SER A 889
 None
 0.76A 5gsnA-2hcsA:
undetectable		 5gsnA-2hcsA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)
(West
Nile
virus) 		5 / 12 ALA A 388
LEU A 387
PHE A 615
PHE A 493
LEU A 559
 None
 1.18A 5k9dA-2hcsA:
undetectable		 5k9dA-2hcsA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)
(West
Nile
virus) 		3 / 3 TYR A 771
ARG A 774
THR A 731
 None
 0.97A 5z84J-2hcsA:
undetectable		 5z84J-2hcsA:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)
(West
Nile
virus) 		5 / 12 ALA A 764
ALA A 781
ILE A 872
ALA A 760
LEU A 891
 None
 1.20A 6a5zD-2hcsA:
undetectable		 6a5zD-2hcsA:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)
(West
Nile
virus) 		4 / 7 HIS A 684
ASN A 687
TRP A 699
ARG A 624
 None
 1.25A 6b8kA-2hcsA:
undetectable		 6b8kA-2hcsA:
9.46