SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hcu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2hcu 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT
(Streptococcus
mutans) 		4 / 7 PHE A  29
TYR A  48
PRO A  26
GLU A  45
 None
 1.15A 1oniA-2hcuA:
undetectable
1oniB-2hcuA:
undetectable		 1oniA-2hcuA:
20.85
1oniB-2hcuA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2hcu 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT
(Streptococcus
mutans) 		4 / 7 TYR A  48
PRO A  26
GLU A  45
PHE A  29
 None
 1.08A 1oniG-2hcuA:
undetectable
1oniI-2hcuA:
undetectable		 1oniG-2hcuA:
20.85
1oniI-2hcuA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2hcu 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT
(Streptococcus
mutans) 		4 / 4 LEU A  91
MET A   1
ILE A 121
ASP A 106
 None
 1.34A 3hecA-2hcuA:
undetectable		 3hecA-2hcuA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 2hcu 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT
(Streptococcus
mutans) 		4 / 6 ARG A  47
ILE A  60
VAL A  12
LEU A  72
 None
 1.10A 4em2A-2hcuA:
undetectable		 4em2A-2hcuA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 2hcu 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT
(Streptococcus
mutans) 		5 / 12 LEU A  42
THR A  74
ILE A  99
ALA A  87
ILE A  19
 None
 0.96A 4rp8C-2hcuA:
undetectable		 4rp8C-2hcuA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 2hcu 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT
(Streptococcus
mutans) 		5 / 12 GLY A  79
GLY A  81
ILE A 107
PHE A  78
LEU A  25
 None
 0.91A 5fa8A-2hcuA:
undetectable		 5fa8A-2hcuA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2hcu 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT
(Streptococcus
mutans) 		4 / 7 GLY A  75
LYS A 124
ASP A 128
ASN A  18
 None
 0.96A 5mvsA-2hcuA:
undetectable		 5mvsA-2hcuA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2hcu 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT
(Streptococcus
mutans) 		4 / 7 GLY A 102
LYS A 124
ASP A 128
ASN A  77
 None
 0.99A 5mvsA-2hcuA:
undetectable		 5mvsA-2hcuA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_1
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 2hcu 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT
(Streptococcus
mutans) 		5 / 12 GLY A 105
PHE A 104
LEU A  42
PHE A  78
THR A  74
 None
 1.26A 5nknA-2hcuA:
0.0		 5nknA-2hcuA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2hcu 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT
(Streptococcus
mutans) 		5 / 12 LEU A  91
PHE A   4
VAL A 141
THR A  74
LEU A  14
 None
 1.17A 6djzB-2hcuA:
undetectable		 6djzB-2hcuA:
20.00