SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hd3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TW4_A_CHDA130_0 (FATTY ACID-BINDING PROTEIN)	2hd3	ETHANOLAMINE UTILIZATION PROTEIN EUTN (Escherichia coli)	5 / 12	LEU A 25 LEU A 24 ALA A 49 ILE A 81 LEU A 76	None	1.13A	1tw4A-2hd3A: undetectable	1tw4A-2hd3A: 18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YC2_E_NCAE507_0 (NAD-DEPENDENT DEACETYLASE 2)	2hd3	ETHANOLAMINE UTILIZATION PROTEIN EUTN (Escherichia coli)	4 / 7	ILE A 44 LEU A 57 ASN A 46 ASP A 22	None	0.91A	1yc2E-2hd3A: undetectable	1yc2E-2hd3A: 17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2KOT_B_ANWB99_0 (PROTEIN S100-A13)	2hd3	ETHANOLAMINE UTILIZATION PROTEIN EUTN (Escherichia coli)	4 / 8	VAL A 6 THR A 51 LYS A 23 ASP A 45	None	1.09A	2kotB-2hd3A: undetectable	2kotB-2hd3A: 17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4I41_A_MIXA501_1 (SERINE/THREONINE-PRO TEIN KINASE PIM-1)	2hd3	ETHANOLAMINE UTILIZATION PROTEIN EUTN (Escherichia coli)	5 / 12	ILE A 47 VAL A 74 ASP A 45 ASP A 22 ILE A 44	None	1.32A	4i41A-2hd3A: undetectable	4i41A-2hd3A: 16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RMJ_A_NCAA402_0 (NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2)	2hd3	ETHANOLAMINE UTILIZATION PROTEIN EUTN (Escherichia coli)	4 / 7	ILE A 44 LEU A 57 LEU A 25 ASN A 46	None	0.83A	4rmjA-2hd3A: undetectable	4rmjA-2hd3A: 14.00

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1TW4_A_CHDA130_0","FATTY ACID-BINDING PROTEIN","2hd3","ETHANOLAMINE UTILIZATION PROTEIN EUTN","Escherichia coli",5,"LEU A  25;LEU A  24;ALA A  49;ILE A  81;LEU A  76","None","1.13A","1tw4A-2hd3A:undetectable","1tw4A-2hd3A:18.46"],["1YC2_E_NCAE507_0","NAD-DEPENDENT DEACETYLASE 2","2hd3","ETHANOLAMINE UTILIZATION PROTEIN EUTN","Escherichia coli",4,"ILE A  44;LEU A  57;ASN A  46;ASP A  22","None","0.91A","1yc2E-2hd3A:undetectable","1yc2E-2hd3A:17.72"],["2KOT_B_ANWB99_0","PROTEIN S100-A13","2hd3","ETHANOLAMINE UTILIZATION PROTEIN EUTN","Escherichia coli",4,"VAL A   6;THR A  51;LYS A  23;ASP A  45","None","1.09A","2kotB-2hd3A:undetectable","2kotB-2hd3A:17.95"],["4I41_A_MIXA501_1","SERINE\/THREONINE-PROTEIN KINASE PIM-1","2hd3","ETHANOLAMINE UTILIZATION PROTEIN EUTN","Escherichia coli",5,"ILE A  47;VAL A  74;ASP A  45;ASP A  22;ILE A  44","None","1.32A","4i41A-2hd3A:undetectable","4i41A-2hd3A:16.43"],["4RMJ_A_NCAA402_0","NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2","2hd3","ETHANOLAMINE UTILIZATION PROTEIN EUTN","Escherichia coli",4,"ILE A  44;LEU A  57;LEU A  25;ASN A  46","None","0.83A","4rmjA-2hd3A:undetectable","4rmjA-2hd3A:14.00"]]