SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hda'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 2hda PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE YES
(Homo
sapiens) 		4 / 8 GLY A 140
ALA A 131
THR A 124
ILE A 142
 None
 0.83A 2dtjA-2hdaA:
undetectable
2dtjB-2hdaA:
undetectable		 2dtjA-2hdaA:
18.40
2dtjB-2hdaA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 2hda PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE YES
(Homo
sapiens) 		4 / 8 GLY A 140
GLU A 130
ALA A 131
ILE A 142
 None
 0.80A 2dtjA-2hdaA:
undetectable
2dtjB-2hdaA:
undetectable		 2dtjA-2hdaA:
18.40
2dtjB-2hdaA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 2hda PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE YES
(Homo
sapiens) 		5 / 9 ILE A 142
ILE A 121
GLY A 140
ALA A 131
THR A 124
 None
 1.06A 2dtjA-2hdaA:
undetectable
2dtjB-2hdaA:
undetectable		 2dtjA-2hdaA:
18.40
2dtjB-2hdaA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 2hda PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE YES
(Homo
sapiens) 		5 / 9 ILE A 142
ILE A 121
GLY A 140
GLU A 130
ALA A 131
 None
 1.04A 2dtjA-2hdaA:
undetectable
2dtjB-2hdaA:
undetectable		 2dtjA-2hdaA:
18.40
2dtjB-2hdaA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 2hda PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE YES
(Homo
sapiens) 		4 / 4 ALA A 131
VAL A  93
PHE A  96
THR A 124
 None
 1.35A 2pkkA-2hdaA:
undetectable		 2pkkA-2hdaA:
10.82