SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hdi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 2hdi COLICIN I RECEPTOR
(Escherichia
coli) 		5 / 12 THR A  36
GLN A  42
ARG A 397
LEU A 143
TYR A 144
 None
 1.18A 1httC-2hdiA:
undetectable		 1httC-2hdiA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 2hdi COLICIN I RECEPTOR
(Escherichia
coli) 		5 / 12 THR A  36
GLN A  42
ARG A 397
LEU A 143
ALA A  47
 None
 1.27A 1httD-2hdiA:
undetectable		 1httD-2hdiA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 2hdi COLICIN I RECEPTOR
(Escherichia
coli) 		5 / 12 THR A  36
GLN A  42
ARG A 397
LEU A 143
TYR A 144
 None
 1.21A 1httD-2hdiA:
undetectable		 1httD-2hdiA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 2hdi COLICIN I RECEPTOR
(Escherichia
coli) 		3 / 3 ASP A 578
TYR A 590
GLU A  73
 None
 0.77A 1vm1A-2hdiA:
undetectable		 1vm1A-2hdiA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2hdi COLICIN I RECEPTOR
(Escherichia
coli) 		3 / 3 THR A 157
ASP A 258
SER A 234
 None
 0.85A 2nxeB-2hdiA:
undetectable		 2nxeB-2hdiA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 2hdi COLICIN I RECEPTOR
(Escherichia
coli) 		5 / 12 GLY A 138
SER A 452
SER A 146
SER A 395
HIS A 393
 None
 1.09A 3d91B-2hdiA:
undetectable		 3d91B-2hdiA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2hdi COLICIN I RECEPTOR
(Escherichia
coli) 		4 / 6 VAL A 108
ILE A 125
ILE A 101
LEU A 102
 None
 0.61A 3hegA-2hdiA:
undetectable		 3hegA-2hdiA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 2hdi COLICIN I RECEPTOR
(Escherichia
coli) 		3 / 3 ARG A 180
ASP A 182
ASP A 179
 None
 0.85A 3jayA-2hdiA:
undetectable		 3jayA-2hdiA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 2hdi COLICIN I RECEPTOR
(Escherichia
coli) 		3 / 3 ARG A 180
ASP A 182
ASP A 179
 None
 0.76A 3jb2A-2hdiA:
undetectable		 3jb2A-2hdiA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 2hdi COLICIN I RECEPTOR
(Escherichia
coli) 		3 / 3 ARG A 180
ASP A 182
ASP A 179
 None
 0.71A 3jb3A-2hdiA:
undetectable		 3jb3A-2hdiA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 2hdi COLICIN I RECEPTOR
(Escherichia
coli) 		3 / 3 THR A 576
SER A 592
ARG A  61
 None
 0.75A 3phnA-2hdiA:
undetectable		 3phnA-2hdiA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 2hdi COLICIN I RECEPTOR
(Escherichia
coli) 		4 / 7 LEU A  71
VAL A  89
VAL A 153
ASP A 121
 None
 0.81A 3rgfA-2hdiA:
undetectable		 3rgfA-2hdiA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 2hdi COLICIN I RECEPTOR
(Escherichia
coli) 		4 / 7 LEU A  94
VAL A 482
LEU A 568
ASP A 556
 None
 0.70A 3rgfA-2hdiA:
undetectable		 3rgfA-2hdiA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 2hdi COLICIN I RECEPTOR
(Escherichia
coli) 		4 / 6 SER A 546
HIS A 594
THR A 576
ARG A  61
 None
 1.08A 3thrB-2hdiA:
undetectable		 3thrB-2hdiA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 2hdi COLICIN I RECEPTOR
(Escherichia
coli) 		3 / 3 PHE A 120
VAL A 299
GLU A 297
 None
 0.82A 4fvqA-2hdiA:
undetectable		 4fvqA-2hdiA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2hdi COLICIN I RECEPTOR
(Escherichia
coli) 		4 / 8 SER A 110
ASP A 121
GLU A 297
THR A  99
 None
 1.13A 4lnwA-2hdiA:
undetectable		 4lnwA-2hdiA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 2hdi COLICIN I RECEPTOR
(Escherichia
coli) 		4 / 7 GLU A 450
TYR A  98
ASP A 556
ALA A 526
 None
 0.90A 4zz8A-2hdiA:
undetectable		 4zz8A-2hdiA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2hdi COLICIN I RECEPTOR
(Escherichia
coli) 		5 / 8 VAL A 114
VAL A 153
ILE A 133
ILE A 125
PHE A 120
 None
 1.08A 5hi2A-2hdiA:
undetectable		 5hi2A-2hdiA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2hdi COLICIN I RECEPTOR
COLICIN-IA
(Escherichia
coli) 		4 / 5 GLY A 352
THR A 353
GLY B 310
LEU A 424
 None
 0.92A 5jlcA-2hdiA:
undetectable		 5jlcA-2hdiA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 2hdi COLICIN I RECEPTOR
(Escherichia
coli) 		3 / 3 VAL A 135
GLU A 472
GLU A 534
 None
 0.68A 5jsdB-2hdiA:
1.0
5jsdC-2hdiA:
0.0		 5jsdB-2hdiA:
23.88
5jsdC-2hdiA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2hdi COLICIN I RECEPTOR
(Escherichia
coli) 		3 / 3 LYS A  68
LEU A  59
ILE A 155
 None
 0.73A 5kc0A-2hdiA:
undetectable		 5kc0A-2hdiA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 2hdi COLICIN I RECEPTOR
COLICIN-IA
(Escherichia
coli;
Escherichia
coli) 		4 / 8 GLY B 361
ARG B 313
GLN A 425
ASP B 311
 None
 0.87A 5vlmA-2hdiB:
undetectable		 5vlmA-2hdiB:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2hdi COLICIN I RECEPTOR
(Escherichia
coli) 		4 / 6 GLU A 650
TYR A 612
GLY A 611
GLY A 610
 None
 0.87A 5x7pB-2hdiA:
undetectable		 5x7pB-2hdiA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 2hdi COLICIN I RECEPTOR
(Escherichia
coli) 		3 / 3 TYR A 390
HIS A 393
MET A 384
 None
 1.17A 6af6A-2hdiA:
undetectable		 6af6A-2hdiA:
19.97