SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hdn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 2hdn ELONGATION FACTOR
EF-TU
(Escherichia
coli) 		5 / 12 ILE B 356
LEU B 343
TYR B 326
ILE B 341
PHE B 323
 None
 1.08A 1fmlB-2hdnB:
undetectable		 1fmlB-2hdnB:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 2hdn ELONGATION FACTOR
EF-TU
(Escherichia
coli) 		4 / 8 ASP B 369
ILE B 298
PRO B 213
LEU B 211
 None
 0.90A 1hmyA-2hdnB:
undetectable		 1hmyA-2hdnB:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 2hdn ELONGATION FACTOR
EF-TU
(Escherichia
coli) 		5 / 9 GLY B 316
ASP B 314
GLY B 353
ILE B 310
ILE B  60
 None
 1.09A 1hxwA-2hdnB:
undetectable		 1hxwA-2hdnB:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2hdn ELONGATION FACTOR
EF-TU
(Escherichia
coli) 		3 / 3 ILE B 363
LEU B 362
VAL B 360
 None
 0.44A 1mz9B-2hdnB:
undetectable		 1mz9B-2hdnB:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 2hdn ELONGATION FACTOR
EF-TU
(Escherichia
coli) 		4 / 7 VAL B 308
GLY B 386
ILE B 341
VAL B 360
 None
 0.78A 1p2yA-2hdnB:
undetectable		 1p2yA-2hdnB:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2hdn ELONGATION FACTOR
EF-TU
(Escherichia
coli) 		4 / 8 GLY B 386
VAL B 308
GLU B 307
ILE B 376
 None
 0.85A 1pk7B-2hdnB:
4.4		 1pk7B-2hdnB:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_2
(PROTEASE)		 2hdn ELONGATION FACTOR
EF-TU
(Escherichia
coli) 		5 / 9 GLY B 316
ASP B 314
GLY B 353
ILE B 310
ILE B  60
 None
 0.85A 2idwB-2hdnB:
undetectable		 2idwB-2hdnB:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 2hdn ELONGATION FACTOR
EF-TU
(Escherichia
coli) 		3 / 3 ARG B 123
VAL B 132
THR B 167
 None
 0.74A 3cyxA-2hdnB:
undetectable		 3cyxA-2hdnB:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_PNTB901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 2hdn ELONGATION FACTOR
EF-TU
(Escherichia
coli) 		5 / 12 ASP B  80
GLY B 100
VAL B 127
TYR B  87
ASN B  90
 TAC  B1888 (-3.5A)
None
None
None
None
 1.48A 3hiiB-2hdnB:
0.0		 3hiiB-2hdnB:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 2hdn ELONGATION FACTOR
EF-TU
(Escherichia
coli) 		5 / 11 LEU B 103
ASP B 161
GLY B 126
VAL B 125
ILE B 130
 None
 0.95A 3oxxD-2hdnB:
undetectable		 3oxxD-2hdnB:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 2hdn ELONGATION FACTOR
EF-TU
(Escherichia
coli) 		5 / 10 PHE B 322
VAL B 308
PHE B 374
PHE B 304
GLY B 339
 None
 1.44A 3r6wA-2hdnB:
5.3
3r6wB-2hdnB:
undetectable		 3r6wA-2hdnB:
21.92
3r6wB-2hdnB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_2
(ASPARTYL PROTEASE)		 2hdn ELONGATION FACTOR
EF-TU
(Escherichia
coli) 		5 / 10 GLY B 316
ASP B 314
GLY B 353
ILE B 310
ILE B  60
 None
 0.89A 4dqfB-2hdnB:
2.2		 4dqfB-2hdnB:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 2hdn ELONGATION FACTOR
EF-TU
(Escherichia
coli) 		4 / 8 ILE B 214
LEU B 292
ILE B 281
GLY B 257
 None
 0.85A 4hb8A-2hdnB:
undetectable		 4hb8A-2hdnB:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2hdn ELONGATION FACTOR
EF-TU
(Escherichia
coli) 		4 / 7 LEU B 311
THR B 382
THR B  93
GLY B 386
 None
 0.96A 4l39B-2hdnB:
1.4		 4l39B-2hdnB:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8W_I_MTXI301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 2hdn ELONGATION FACTOR
EF-TU
(Escherichia
coli) 		5 / 9 PHE B 374
GLY B 317
GLY B 384
LEU B 311
GLU B 315
 None
 1.22A 4l8wI-2hdnB:
1.4		 4l8wI-2hdnB:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 2hdn ELONGATION FACTOR
EF-TU
(Escherichia
coli) 		5 / 12 PHE B 322
LEU B 311
GLY B 339
THR B 382
MET B 358
 None
 1.25A 4mubA-2hdnB:
undetectable		 4mubA-2hdnB:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)		 2hdn ELONGATION FACTOR
EF-TU
(Escherichia
coli) 		6 / 11 GLY B 316
ASP B 314
GLY B 353
ILE B 310
THR B  93
ILE B  60
 None
 1.23A 4njvB-2hdnB:
undetectable		 4njvB-2hdnB:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2hdn ELONGATION FACTOR
EF-TU
(Escherichia
coli) 		4 / 5 GLY B  83
ASP B  86
GLU B 117
VAL B 125
 None
 1.08A 4nkvD-2hdnB:
undetectable		 4nkvD-2hdnB:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 2hdn ELONGATION FACTOR
EF-TU
(Escherichia
coli) 		5 / 12 LEU B 121
LEU B 157
VAL B 132
VAL B 127
PHE B 162
 None
 1.17A 4wnwA-2hdnB:
undetectable		 4wnwA-2hdnB:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 2hdn ELONGATION FACTOR
EF-TU
(Escherichia
coli) 		3 / 3 GLU B 232
ILE B 366
ALA B 293
 None
 0.63A 4wnwB-2hdnB:
undetectable		 4wnwB-2hdnB:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 2hdn ELONGATION FACTOR
EF-TU
(Escherichia
coli) 		5 / 9 LEU B 134
PRO B 111
VAL B 132
SER B 158
LEU B 156
 None
 1.33A 6fdyU-2hdnB:
undetectable		 6fdyU-2hdnB:
20.49