SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hdw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 2hdw HYPOTHETICAL PROTEIN
PA2218
(Pseudomonas
aeruginosa) 		4 / 8 ARG A 358
LEU A 337
GLY A 177
ILE A 176
 None
 0.80A 1d4sB-2hdwA:
undetectable		 1d4sB-2hdwA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2hdw HYPOTHETICAL PROTEIN
PA2218
(Pseudomonas
aeruginosa) 		4 / 6 ILE A 173
GLU A 167
LEU A  87
LEU A 128
 None
 1.03A 1mt1B-2hdwA:
undetectable
1mt1C-2hdwA:
undetectable		 1mt1B-2hdwA:
15.47
1mt1C-2hdwA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2hdw HYPOTHETICAL PROTEIN
PA2218
(Pseudomonas
aeruginosa) 		4 / 7 ARG A 123
ALA A 360
ILE A 354
ILE A 176
 None
 0.98A 1oniD-2hdwA:
1.0
1oniF-2hdwA:
undetectable		 1oniD-2hdwA:
17.98
1oniF-2hdwA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 2hdw HYPOTHETICAL PROTEIN
PA2218
(Pseudomonas
aeruginosa) 		4 / 4 HIS A 274
VAL A 108
THR A  53
LEU A  50
 None
 1.46A 1oq5A-2hdwA:
undetectable		 1oq5A-2hdwA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 2hdw HYPOTHETICAL PROTEIN
PA2218
(Pseudomonas
aeruginosa) 		5 / 8 ALA A 188
GLY A 182
GLY A 177
ILE A 176
ALA A 158
 None
 1.23A 1sguA-2hdwA:
undetectable		 1sguA-2hdwA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 2hdw HYPOTHETICAL PROTEIN
PA2218
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 262
TYR A 263
TYR A 204
HIS A 318
 None
 1.08A 2bteA-2hdwA:
undetectable		 2bteA-2hdwA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 2hdw HYPOTHETICAL PROTEIN
PA2218
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 262
TYR A 263
TYR A 204
HIS A 318
 None
 0.94A 2bteD-2hdwA:
undetectable		 2bteD-2hdwA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_A_LEUA1301_0
(LEUCYL-TRNA
SYNTHETASE)		 2hdw HYPOTHETICAL PROTEIN
PA2218
(Pseudomonas
aeruginosa) 		4 / 7 ASP A 262
TYR A 263
TYR A 204
HIS A 318
 None
 1.09A 2bytA-2hdwA:
undetectable		 2bytA-2hdwA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_D_LEUD1601_0
(LEUCYL-TRNA
SYNTHETASE)		 2hdw HYPOTHETICAL PROTEIN
PA2218
(Pseudomonas
aeruginosa) 		4 / 7 ASP A 262
TYR A 263
TYR A 204
HIS A 318
 None
 1.08A 2bytD-2hdwA:
undetectable		 2bytD-2hdwA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 2hdw HYPOTHETICAL PROTEIN
PA2218
(Pseudomonas
aeruginosa) 		3 / 3 THR A 202
PRO A 104
TYR A 348
 None
 0.97A 2dxrA-2hdwA:
undetectable		 2dxrA-2hdwA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_2
(YAEB-LIKE PROTEIN
RPA0152)		 2hdw HYPOTHETICAL PROTEIN
PA2218
(Pseudomonas
aeruginosa) 		4 / 5 HIS A 264
ARG A 353
ASP A 349
THR A 269
 None
 1.38A 3okxB-2hdwA:
0.0		 3okxB-2hdwA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 2hdw HYPOTHETICAL PROTEIN
PA2218
(Pseudomonas
aeruginosa) 		4 / 7 ARG A 358
LEU A 337
GLY A 177
ILE A 176
 None
 0.79A 3spkB-2hdwA:
undetectable		 3spkB-2hdwA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2hdw HYPOTHETICAL PROTEIN
PA2218
(Pseudomonas
aeruginosa) 		3 / 3 ASP A  84
ARG A 276
LYS A 109
 None
 1.12A 3wipG-2hdwA:
undetectable		 3wipG-2hdwA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 2hdw HYPOTHETICAL PROTEIN
PA2218
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 136
GLY A 139
GLY A 140
ASP A 131
VAL A 278
 None
 1.03A 4b17A-2hdwA:
undetectable		 4b17A-2hdwA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 2hdw HYPOTHETICAL PROTEIN
PA2218
(Pseudomonas
aeruginosa) 		5 / 12 SER A 112
GLY A 182
CYH A 179
PRO A 104
GLY A 103
 None
 1.04A 4b17A-2hdwA:
undetectable		 4b17A-2hdwA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM7_A_29JA603_1
(TRANSPORTER)		 2hdw HYPOTHETICAL PROTEIN
PA2218
(Pseudomonas
aeruginosa) 		5 / 10 TYR A 116
ASP A 349
TYR A 263
SER A 112
GLY A 103
 None
 1.49A 4mm7A-2hdwA:
undetectable		 4mm7A-2hdwA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 2hdw HYPOTHETICAL PROTEIN
PA2218
(Pseudomonas
aeruginosa) 		4 / 6 ALA A 158
SER A 113
ASP A 131
PRO A 132
 None
 1.12A 5c6pA-2hdwA:
undetectable		 5c6pA-2hdwA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2hdw HYPOTHETICAL PROTEIN
PA2218
(Pseudomonas
aeruginosa) 		5 / 11 ILE A 101
ILE A  99
PHE A 125
ILE A 359
ALA A 360
 None
 1.02A 5lg3A-2hdwA:
undetectable		 5lg3A-2hdwA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2hdw HYPOTHETICAL PROTEIN
PA2218
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 101
ILE A  99
PHE A 125
ILE A 359
ALA A 360
 None
 1.03A 5lg3E-2hdwA:
undetectable		 5lg3E-2hdwA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 2hdw HYPOTHETICAL PROTEIN
PA2218
(Pseudomonas
aeruginosa) 		4 / 5 HIS A 344
SER A 319
TYR A 321
TYR A 214
 None
 1.49A 5yodH-2hdwA:
undetectable		 5yodH-2hdwA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 2hdw HYPOTHETICAL PROTEIN
PA2218
(Pseudomonas
aeruginosa) 		3 / 3 PHE A 130
ASP A  84
LYS A 109
 None
 0.69A 6awtD-2hdwA:
undetectable		 6awtD-2hdwA:
19.20