SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hdx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 2hdx SH2-B PH DOMAIN
CONTAINING SIGNALING
MEDIATOR 1 GAMMA
ISOFORM
(Mus
musculus) 		3 / 3 LEU A 577
LEU A 581
PHE A 604
 None
 0.71A 2pgrA-2hdxA:
undetectable		 2pgrA-2hdxA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 2hdx SH2-B PH DOMAIN
CONTAINING SIGNALING
MEDIATOR 1 GAMMA
ISOFORM
(Mus
musculus) 		4 / 8 GLY A 524
CYH A 587
MET A 600
PHE A 552
 None
 1.02A 3ko0D-2hdxA:
undetectable
3ko0E-2hdxA:
undetectable		 3ko0D-2hdxA:
21.57
3ko0E-2hdxA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 2hdx SH2-B PH DOMAIN
CONTAINING SIGNALING
MEDIATOR 1 GAMMA
ISOFORM
(Mus
musculus) 		4 / 8 GLY A 530
CYH A 587
MET A 600
PHE A 552
 None
 1.04A 3ko0D-2hdxA:
undetectable
3ko0E-2hdxA:
undetectable		 3ko0D-2hdxA:
21.57
3ko0E-2hdxA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 2hdx SH2-B PH DOMAIN
CONTAINING SIGNALING
MEDIATOR 1 GAMMA
ISOFORM
(Mus
musculus) 		4 / 8 PHE A 552
GLY A 530
CYH A 587
MET A 600
 None
 0.97A 3ko0B-2hdxA:
undetectable
3ko0J-2hdxA:
undetectable		 3ko0B-2hdxA:
21.57
3ko0J-2hdxA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 2hdx SH2-B PH DOMAIN
CONTAINING SIGNALING
MEDIATOR 1 GAMMA
ISOFORM
(Mus
musculus) 		5 / 9 PHE A 568
ALA A 537
LEU A 535
LEU A 566
VAL A 565
 None
 1.17A 4or0A-2hdxA:
undetectable		 4or0A-2hdxA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 2hdx SH2-B PH DOMAIN
CONTAINING SIGNALING
MEDIATOR 1 GAMMA
ISOFORM
(Mus
musculus) 		3 / 3 ASN A 582
LEU A 522
PHE A 594
 None
 0.76A 5dsgA-2hdxA:
undetectable		 5dsgA-2hdxA:
13.91