SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2he3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 2he3 GLUTATHIONE
PEROXIDASE 2
(Homo
sapiens) 		4 / 8 LEU A 185
LEU A 186
LEU A  61
ALA A  30
 None
 0.65A 1e7cA-2he3A:
undetectable		 1e7cA-2he3A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 2he3 GLUTATHIONE
PEROXIDASE 2
(Homo
sapiens) 		4 / 7 PHE A  66
THR A 100
VAL A  21
VAL A  31
 None
 0.90A 1p7rA-2he3A:
undetectable		 1p7rA-2he3A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 2he3 GLUTATHIONE
PEROXIDASE 2
(Homo
sapiens) 		3 / 3 ALA A 117
VAL A 107
TRP A 142
 None
 0.95A 1tkqA-2he3A:
undetectable		 1tkqA-2he3A:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2he3 GLUTATHIONE
PEROXIDASE 2
(Homo
sapiens) 		3 / 3 ILE A  14
ASP A  22
PHE A  23
 None
 0.52A 1uwjB-2he3A:
undetectable		 1uwjB-2he3A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2he3 GLUTATHIONE
PEROXIDASE 2
(Homo
sapiens) 		5 / 12 TYR A 118
PRO A 114
PRO A 165
VAL A 102
ILE A  33
 None
 1.16A 1z9hA-2he3A:
2.9		 1z9hA-2he3A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2he3 GLUTATHIONE
PEROXIDASE 2
(Homo
sapiens) 		5 / 12 TYR A 118
PRO A 114
PRO A 165
VAL A 102
ILE A  33
 None
 1.16A 1z9hB-2he3A:
2.9		 1z9hB-2he3A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2he3 GLUTATHIONE
PEROXIDASE 2
(Homo
sapiens) 		5 / 12 TYR A 118
PRO A 114
PRO A 165
VAL A 102
ILE A  33
 None
 1.16A 1z9hC-2he3A:
3.3		 1z9hC-2he3A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 2he3 GLUTATHIONE
PEROXIDASE 2
(Homo
sapiens) 		3 / 3 ARG A  29
GLY A  28
SER A   7
 None
 0.63A 2xctB-2he3A:
undetectable		 2xctB-2he3A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2he3 GLUTATHIONE
PEROXIDASE 2
(Homo
sapiens) 		5 / 12 LEU A  64
VAL A  21
ILE A  14
LEU A  86
TYR A  95
 None
 1.13A 3g9eA-2he3A:
undetectable		 3g9eA-2he3A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 2he3 GLUTATHIONE
PEROXIDASE 2
(Homo
sapiens) 		3 / 3 PRO A  67
SER A  38
ASN A  69
 None
 0.82A 3lslG-2he3A:
undetectable		 3lslG-2he3A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_B_GLYB509_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2he3 GLUTATHIONE
PEROXIDASE 2
(Homo
sapiens) 		4 / 4 PHE A  47
THR A  43
LEU A  86
TYR A  95
 None
 1.31A 3pgyB-2he3A:
undetectable		 3pgyB-2he3A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2he3 GLUTATHIONE
PEROXIDASE 2
(Homo
sapiens) 		3 / 3 PHE A  66
CYH A 105
HIS A 113
 None
 1.35A 3u9fL-2he3A:
undetectable		 3u9fL-2he3A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2he3 GLUTATHIONE
PEROXIDASE 2
(Homo
sapiens) 		3 / 3 PHE A  66
CYH A 105
HIS A 113
 None
 1.26A 3u9fS-2he3A:
undetectable		 3u9fS-2he3A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 2he3 GLUTATHIONE
PEROXIDASE 2
(Homo
sapiens) 		3 / 3 GLU A 155
TRP A 152
ASN A 108
 None
 1.02A 5dv4A-2he3A:
undetectable		 5dv4A-2he3A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 2he3 GLUTATHIONE
PEROXIDASE 2
(Homo
sapiens) 		5 / 10 LEU A 119
VAL A  31
LEU A  32
PHE A  66
GLU A  34
 None
 1.47A 5tixB-2he3A:
undetectable		 5tixB-2he3A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 2he3 GLUTATHIONE
PEROXIDASE 2
(Homo
sapiens) 		4 / 6 ARG A 168
ARG A 167
PHE A 166
ILE A 182
 None
 0.88A 5vceA-2he3A:
undetectable		 5vceA-2he3A:
18.82