SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2he4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QD2_B_CHDB1_0 (FERROCHELATASE)	2he4	NA(+)/H(+) EXCHANGE REGULATORY COFACTOR NHE-RF2 (Homo sapiens)	5 / 10	LEU A 165 ARG A 195 SER A 188 VAL A 228 GLY A 229	None	1.27A	2qd2B-2he4A: undetectable	2qd2B-2he4A: 13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HCO_B_CHDB924_0 (FERROCHELATASE, MITOCHONDRIAL)	2he4	NA(+)/H(+) EXCHANGE REGULATORY COFACTOR NHE-RF2 (Homo sapiens)	5 / 10	LEU A 165 ARG A 195 SER A 188 VAL A 228 GLY A 229	None	1.24A	3hcoB-2he4A: 0.0	3hcoB-2he4A: 13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KLR_A_CHDA504_0 (FERROCHELATASE, MITOCHONDRIAL)	2he4	NA(+)/H(+) EXCHANGE REGULATORY COFACTOR NHE-RF2 (Homo sapiens)	4 / 7	LEU A 165 ARG A 195 SER A 188 VAL A 228	None	1.18A	4klrA-2he4A: undetectable	4klrA-2he4A: 13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MUG_A_VIVA301_0 (ALPHA-TOCOPHEROL TRANSFER PROTEIN)	2he4	NA(+)/H(+) EXCHANGE REGULATORY COFACTOR NHE-RF2 (Homo sapiens)	5 / 12	ILE A 176 VAL A 227 LEU A 196 VAL A 199 ILE A 216	None	1.00A	5mugA-2he4A: undetectable	5mugA-2he4A: 18.34

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2QD2_B_CHDB1_0","FERROCHELATASE","2he4","NA(+)\/H(+) EXCHANGE REGULATORY COFACTOR NHE-RF2","Homo sapiens",5,"LEU A 165;ARG A 195;SER A 188;VAL A 228;GLY A 229","None","1.27A","2qd2B-2he4A:undetectable","2qd2B-2he4A:13.93"],["3HCO_B_CHDB924_0","FERROCHELATASE, MITOCHONDRIAL","2he4","NA(+)\/H(+) EXCHANGE REGULATORY COFACTOR NHE-RF2","Homo sapiens",5,"LEU A 165;ARG A 195;SER A 188;VAL A 228;GLY A 229","None","1.24A","3hcoB-2he4A:0.0","3hcoB-2he4A:13.93"],["4KLR_A_CHDA504_0","FERROCHELATASE, MITOCHONDRIAL","2he4","NA(+)\/H(+) EXCHANGE REGULATORY COFACTOR NHE-RF2","Homo sapiens",4,"LEU A 165;ARG A 195;SER A 188;VAL A 228","None","1.18A","4klrA-2he4A:undetectable","4klrA-2he4A:13.90"],["5MUG_A_VIVA301_0","ALPHA-TOCOPHEROL TRANSFER PROTEIN","2he4","NA(+)\/H(+) EXCHANGE REGULATORY COFACTOR NHE-RF2","Homo sapiens",5,"ILE A 176;VAL A 227;LEU A 196;VAL A 199;ILE A 216","None","1.00A","5mugA-2he4A:undetectable","5mugA-2he4A:18.34"]]