SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hen'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 VAL A 643
ALA A 659
GLU A 678
MET A 682
THR A 707
PHE A 709
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.8A)
 0.89A 1iepA-2henA:
26.2		 1iepA-2henA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 VAL A 643
ALA A 659
GLU A 678
MET A 682
THR A 707
PHE A 709
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.8A)
 0.90A 1iepB-2henA:
26.3		 1iepB-2henA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 VAL A 643
ALA A 659
GLU A 678
MET A 682
THR A 707
PHE A 709
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.8A)
 0.88A 1opjB-2henA:
31.3		 1opjB-2henA:
39.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		3 / 3 ARG A 833
ILE A 822
TRP A 800
 None
 1.14A 1qomA-2henA:
undetectable		 1qomA-2henA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		4 / 7 ASN A 759
HIS A 752
PHE A 773
ILE A 738
 MG  A 404 (-4.5A)
None
None
None
 1.27A 1tdnA-2henA:
undetectable		 1tdnA-2henA:
21.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		4 / 6 VAL A 823
ILE A 884
ILE A 738
ASP A 816
 None
 0.83A 1uwhB-2henA:
28.3		 1uwhB-2henA:
32.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 12 VAL A 643
ALA A 659
GLU A 678
THR A 707
LEU A 745
HIS A 752
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
ADP  A 400 (-4.7A)
None
None
 0.92A 1uwjA-2henA:
27.8		 1uwjA-2henA:
32.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 12 ILE A 635
VAL A 643
ALA A 659
GLU A 678
THR A 707
LEU A 745
 ADP  A 400 (-4.9A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
ADP  A 400 (-4.7A)
None
 0.99A 1uwjB-2henA:
7.5		 1uwjB-2henA:
32.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 12 VAL A 643
ALA A 659
GLU A 678
THR A 707
LEU A 745
HIS A 752
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
ADP  A 400 (-4.7A)
None
None
 0.92A 1uwjB-2henA:
7.5		 1uwjB-2henA:
32.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		8 / 12 ALA A 659
GLU A 678
MET A 682
ILE A 705
THR A 707
PHE A 709
GLY A 713
LEU A 761
 ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 0.66A 2gqgA-2henA:
32.6		 2gqgA-2henA:
38.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 12 VAL A 643
ALA A 659
GLU A 678
MET A 682
PHE A 709
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
None
ADP  A 400 ( 4.8A)
 0.81A 2hyyA-2henA:
26.2		 2hyyA-2henA:
39.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 12 VAL A 643
ALA A 659
MET A 682
THR A 707
PHE A 709
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.8A)
 0.81A 2hyyA-2henA:
26.2		 2hyyA-2henA:
39.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 12 VAL A 643
ALA A 659
THR A 707
PHE A 709
LEU A 761
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.85A 2hyyA-2henA:
26.2		 2hyyA-2henA:
39.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 12 VAL A 643
ALA A 659
GLU A 678
MET A 682
PHE A 709
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
None
ADP  A 400 ( 4.8A)
 0.79A 2hyyB-2henA:
26.3		 2hyyB-2henA:
39.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 12 VAL A 643
ALA A 659
MET A 682
THR A 707
PHE A 709
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.8A)
 0.80A 2hyyB-2henA:
26.3		 2hyyB-2henA:
39.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 12 VAL A 643
ALA A 659
THR A 707
PHE A 709
LEU A 761
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.81A 2hyyB-2henA:
26.3		 2hyyB-2henA:
39.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		8 / 12 VAL A 643
ALA A 659
GLU A 678
MET A 682
ILE A 705
THR A 707
PHE A 709
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.8A)
 0.91A 2hyyD-2henA:
26.2		 2hyyD-2henA:
39.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 VAL A 643
ALA A 659
ILE A 681
ILE A 705
THR A 707
LEU A 761
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 1.32A 2hyyD-2henA:
26.2		 2hyyD-2henA:
39.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 VAL A 643
ALA A 659
ILE A 705
THR A 707
PHE A 709
LEU A 761
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.76A 2hyyD-2henA:
26.2		 2hyyD-2henA:
39.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		3 / 3 ALA A 659
GLY A 713
SER A 771
 ADP  A 400 (-3.2A)
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.8A)
 0.41A 2ivuA-2henA:
24.1		 2ivuA-2henA:
33.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 VAL A 643
ALA A 659
GLU A 678
MET A 682
ILE A 705
THR A 707
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.8A)
 0.69A 2oiqA-2henA:
27.2		 2oiqA-2henA:
42.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 VAL A 643
ALA A 659
GLU A 678
MET A 682
ILE A 705
THR A 707
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.8A)
 0.83A 2pl0A-2henA:
25.5		 2pl0A-2henA:
40.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		9 / 12 ILE A 635
ALA A 659
GLU A 678
MET A 682
ILE A 705
THR A 707
GLY A 713
LEU A 761
SER A 771
 ADP  A 400 (-4.9A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.85A 2y6oA-2henA:
38.8		 2y6oA-2henA:
81.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		8 / 12 ILE A 635
ALA A 659
LYS A 661
GLU A 678
MET A 682
ILE A 705
THR A 707
SER A 771
 ADP  A 400 (-4.9A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
ADP  A 400 ( 4.9A)
None
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.8A)
 0.87A 2y6oA-2henA:
38.8		 2y6oA-2henA:
81.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 ILE A 635
VAL A 643
ALA A 659
ILE A 691
MET A 710
GLY A 713
LEU A 761
 ADP  A 400 (-4.9A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 0.74A 2y7jA-2henA:
20.3		 2y7jA-2henA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 10 ILE A 635
VAL A 643
ALA A 659
ILE A 691
MET A 710
GLY A 713
LEU A 761
 ADP  A 400 (-4.9A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 0.64A 2y7jB-2henA:
13.4		 2y7jB-2henA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 10 ILE A 635
VAL A 643
ALA A 659
ILE A 691
MET A 710
GLY A 713
LEU A 761
 ADP  A 400 (-4.9A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 0.69A 2y7jC-2henA:
20.3		 2y7jC-2henA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 10 ILE A 635
VAL A 643
ALA A 659
ILE A 691
MET A 710
GLY A 713
LEU A 761
 ADP  A 400 (-4.9A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 0.60A 2y7jD-2henA:
19.9		 2y7jD-2henA:
20.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		4 / 8 ALA A 659
MET A 710
GLY A 713
LEU A 761
 ADP  A 400 (-3.2A)
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 0.18A 2yfxA-2henA:
33.1		 2yfxA-2henA:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		4 / 8 MET A 710
GLY A 713
LEU A 761
ASP A 772
 None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.60A 2yfxA-2henA:
33.1		 2yfxA-2henA:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		8 / 12 ALA A 659
GLU A 678
MET A 682
ILE A 705
THR A 707
MET A 710
GLY A 713
LEU A 761
 ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 0.67A 2zvaA-2henA:
26.4		 2zvaA-2henA:
40.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		8 / 12 ALA A 659
LYS A 661
GLU A 678
MET A 682
ILE A 705
THR A 707
MET A 710
LEU A 761
 ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
ADP  A 400 ( 4.9A)
None
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.7A)
 0.67A 2zvaA-2henA:
26.4		 2zvaA-2henA:
40.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		5 / 10 VAL A 643
ILE A 705
PHE A 709
VAL A 770
ASP A 772
 ADP  A 400 ( 4.4A)
None
None
None
ADP  A 400 ( 4.8A)
 0.52A 3cs9A-2henA:
26.3		 3cs9A-2henA:
39.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 ALA A 659
GLU A 678
MET A 682
THR A 707
PHE A 709
HIS A 752
ASP A 772
 ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
None
None
ADP  A 400 ( 4.8A)
 1.14A 3cs9C-2henA:
31.6		 3cs9C-2henA:
39.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		5 / 12 ALA A 659
GLU A 678
MET A 682
THR A 707
PHE A 709
 ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
None
 0.61A 3cs9D-2henA:
26.5		 3cs9D-2henA:
39.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 12 VAL A 643
ALA A 659
ILE A 691
THR A 707
HIS A 752
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.8A)
 1.25A 3gcsA-2henA:
13.5		 3gcsA-2henA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 12 ALA A 659
GLU A 678
ILE A 691
THR A 707
HIS A 752
ASP A 772
 ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.8A)
 1.10A 3gp0A-2henA:
21.8		 3gp0A-2henA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 12 VAL A 643
ALA A 659
GLU A 678
ILE A 691
THR A 707
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.8A)
 0.85A 3gp0A-2henA:
21.8		 3gp0A-2henA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 12 ALA A 659
LYS A 661
GLU A 678
ILE A 691
THR A 707
ASP A 772
 ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.8A)
 1.39A 3hegA-2henA:
21.0		 3hegA-2henA:
25.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		8 / 12 ALA A 659
LYS A 661
GLU A 678
MET A 682
ILE A 705
THR A 707
LEU A 761
SER A 771
 ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
ADP  A 400 ( 4.9A)
None
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.80A 3k54A-2henA:
32.6		 3k54A-2henA:
37.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		8 / 12 ALA A 659
LYS A 661
MET A 682
ILE A 705
THR A 707
GLY A 713
LEU A 761
SER A 771
 ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
None
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.74A 3k54A-2henA:
32.6		 3k54A-2henA:
37.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 VAL A 643
ALA A 659
GLU A 678
MET A 682
THR A 707
PHE A 709
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.8A)
 0.85A 3k5vA-2henA:
31.3		 3k5vA-2henA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 VAL A 643
ALA A 659
GLU A 678
MET A 682
THR A 707
PHE A 709
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.8A)
 0.86A 3k5vB-2henA:
31.2		 3k5vB-2henA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 12 VAL A 643
ALA A 659
THR A 707
PHE A 709
LEU A 761
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.78A 3k5vB-2henA:
31.2		 3k5vB-2henA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		8 / 11 ILE A 635
ALA A 659
LYS A 661
PHE A 709
MET A 710
GLY A 713
LEU A 761
SER A 771
 ADP  A 400 (-4.9A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
None
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.68A 3miyA-2henA:
31.1		 3miyA-2henA:
37.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		8 / 9 ILE A 635
ALA A 659
LYS A 661
PHE A 709
MET A 710
GLY A 713
LEU A 761
SER A 771
 ADP  A 400 (-4.9A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
None
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.59A 3miyB-2henA:
34.3		 3miyB-2henA:
37.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 VAL A 643
ALA A 659
GLU A 678
MET A 682
THR A 707
PHE A 709
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.8A)
 0.87A 3ms9A-2henA:
26.2		 3ms9A-2henA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 12 VAL A 643
ALA A 659
THR A 707
PHE A 709
LEU A 761
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.79A 3ms9A-2henA:
26.2		 3ms9A-2henA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 VAL A 643
ALA A 659
GLU A 678
MET A 682
THR A 707
PHE A 709
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.8A)
 0.89A 3ms9B-2henA:
26.3		 3ms9B-2henA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 VAL A 643
ALA A 659
GLU A 678
MET A 682
THR A 707
PHE A 709
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.8A)
 0.89A 3mssA-2henA:
26.3		 3mssA-2henA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 12 VAL A 643
ALA A 659
THR A 707
PHE A 709
LEU A 761
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.81A 3mssA-2henA:
26.3		 3mssA-2henA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 12 VAL A 643
ALA A 659
GLU A 678
MET A 682
PHE A 709
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
None
ADP  A 400 ( 4.8A)
 0.81A 3mssC-2henA:
26.2		 3mssC-2henA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 12 VAL A 643
ALA A 659
MET A 682
THR A 707
PHE A 709
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.8A)
 0.82A 3mssC-2henA:
26.2		 3mssC-2henA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 12 VAL A 643
ALA A 659
THR A 707
PHE A 709
LEU A 761
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.82A 3mssC-2henA:
26.2		 3mssC-2henA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 12 ALA A 659
GLU A 678
MET A 682
THR A 707
PHE A 709
ASP A 772
 ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.8A)
 0.87A 3mssD-2henA:
26.5		 3mssD-2henA:
39.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		3 / 3 ARG A 833
ILE A 822
TRP A 800
 None
 1.00A 3nw2A-2henA:
undetectable		 3nw2A-2henA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		3 / 3 ARG A 833
ILE A 822
TRP A 800
 None
 1.09A 3nw2B-2henA:
undetectable		 3nw2B-2henA:
19.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 VAL A 643
ALA A 659
MET A 682
ILE A 705
THR A 707
LEU A 761
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.88A 3oezB-2henA:
27.6		 3oezB-2henA:
42.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 12 ILE A 635
VAL A 643
ALA A 659
LYS A 661
THR A 707
PHE A 773
 ADP  A 400 (-4.9A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
ADP  A 400 (-4.7A)
None
 1.11A 3og7A-2henA:
27.8		 3og7A-2henA:
31.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 12 GLY A 636
VAL A 643
ALA A 659
ILE A 691
THR A 707
LEU A 761
 ADP  A 400 ( 3.9A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.7A)
 0.96A 3ohtA-2henA:
17.1		 3ohtA-2henA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 12 GLY A 636
VAL A 643
ALA A 659
LYS A 661
ILE A 691
THR A 707
 ADP  A 400 ( 3.9A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
None
ADP  A 400 (-4.7A)
 0.86A 3ohtA-2henA:
17.1		 3ohtA-2henA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 12 GLY A 636
VAL A 643
ALA A 659
ILE A 691
THR A 707
LEU A 761
 ADP  A 400 ( 3.9A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.7A)
 0.94A 3ohtB-2henA:
17.4		 3ohtB-2henA:
23.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 12 VAL A 643
ALA A 659
GLU A 678
MET A 682
PHE A 709
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
None
ADP  A 400 ( 4.8A)
 0.80A 3pyyA-2henA:
26.3		 3pyyA-2henA:
39.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 12 VAL A 643
ALA A 659
MET A 682
THR A 707
PHE A 709
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.8A)
 0.79A 3pyyA-2henA:
26.3		 3pyyA-2henA:
39.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 VAL A 643
ALA A 659
MET A 682
ILE A 705
THR A 707
GLY A 713
LEU A 761
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 0.66A 3sxrA-2henA:
31.6		 3sxrA-2henA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 VAL A 643
ALA A 659
MET A 682
THR A 707
GLY A 713
LEU A 761
SER A 771
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.82A 3sxrB-2henA:
31.1		 3sxrB-2henA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 ALA A 659
ILE A 705
THR A 707
PHE A 709
MET A 710
GLY A 713
LEU A 761
 ADP  A 400 (-3.2A)
None
ADP  A 400 (-4.7A)
None
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 0.55A 3ue4A-2henA:
28.3		 3ue4A-2henA:
39.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		8 / 12 VAL A 643
ALA A 659
MET A 682
ILE A 705
THR A 707
PHE A 709
GLY A 713
LEU A 761
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 0.88A 3ue4B-2henA:
26.3		 3ue4B-2henA:
39.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 ALA A 659
ILE A 681
MET A 682
ILE A 691
THR A 707
LEU A 761
ASP A 772
 ADP  A 400 (-3.2A)
None
None
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 1.01A 4bkjA-2henA:
29.8		 4bkjA-2henA:
37.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 VAL A 643
ALA A 659
MET A 682
ILE A 691
THR A 707
LEU A 761
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 1.15A 4bkjA-2henA:
29.8		 4bkjA-2henA:
37.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 ALA A 659
ILE A 681
MET A 682
ILE A 691
THR A 707
LEU A 761
ASP A 772
 ADP  A 400 (-3.2A)
None
None
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 1.08A 4bkjB-2henA:
29.8		 4bkjB-2henA:
37.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 12 VAL A 643
ALA A 659
GLU A 678
MET A 682
ILE A 691
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
None
ADP  A 400 ( 4.8A)
 1.00A 4bkjB-2henA:
29.8		 4bkjB-2henA:
37.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 VAL A 643
ALA A 659
MET A 682
ILE A 691
THR A 707
LEU A 761
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 1.23A 4bkjB-2henA:
29.8		 4bkjB-2henA:
37.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 ALA A 659
LYS A 661
GLU A 678
ILE A 705
THR A 707
HIS A 752
ASP A 772
 ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.8A)
 0.93A 4c8bA-2henA:
27.4		 4c8bA-2henA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		3 / 3 LEU A 676
GLU A 678
SER A 680
 None
ADP  A 400 ( 4.9A)
None
 0.84A 4ccqA-2henA:
undetectable		 4ccqA-2henA:
22.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 11 GLY A 636
GLY A 638
VAL A 643
ALA A 659
GLY A 713
SER A 714
LEU A 761
 ADP  A 400 ( 3.9A)
ADP  A 400 ( 4.0A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.2A)
ADP  A 400 (-3.1A)
ADP  A 400 ( 4.7A)
 0.88A 4ckiA-2henA:
26.8		 4ckiA-2henA:
34.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 VAL A 643
ALA A 659
GLU A 678
ILE A 681
MET A 682
THR A 707
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.8A)
 0.78A 4csvA-2henA:
27.4		 4csvA-2henA:
43.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 VAL A 643
ALA A 659
LYS A 661
THR A 707
MET A 710
GLY A 713
LEU A 761
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 0.74A 4hjoA-2henA:
30.1		 4hjoA-2henA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 10 ILE A 635
ALA A 659
PHE A 709
GLY A 713
LEU A 761
SER A 771
 ADP  A 400 (-4.9A)
ADP  A 400 (-3.2A)
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.59A 4ks8A-2henA:
24.6		 4ks8A-2henA:
29.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		5 / 8 VAL A 643
ALA A 659
LYS A 661
MET A 710
LEU A 761
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
None
ADP  A 400 ( 4.7A)
 0.93A 4l9iB-2henA:
21.4		 4l9iB-2henA:
19.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 VAL A 643
ALA A 659
GLU A 678
MET A 682
ILE A 705
THR A 707
GLY A 713
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.2A)
 0.56A 4mxoA-2henA:
27.2		 4mxoA-2henA:
41.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		4 / 6 VAL A 643
ALA A 659
LYS A 661
LEU A 761
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
ADP  A 400 ( 4.7A)
 0.70A 4o0uA-2henA:
8.2		 4o0uA-2henA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		5 / 8 ILE A 635
GLY A 638
VAL A 643
ALA A 659
LEU A 761
 ADP  A 400 (-4.9A)
ADP  A 400 ( 4.0A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.7A)
 0.59A 4ogrA-2henA:
17.1		 4ogrA-2henA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 VAL A 643
ALA A 659
LYS A 661
GLU A 678
MET A 682
THR A 707
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.8A)
 0.90A 4r7iA-2henA:
31.2		 4r7iA-2henA:
29.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		5 / 10 ILE A 635
ALA A 659
LYS A 661
ILE A 691
THR A 707
 ADP  A 400 (-4.9A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
None
ADP  A 400 (-4.7A)
 0.72A 4rz7A-2henA:
7.5		 4rz7A-2henA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		4 / 6 ASN A 749
TYR A 744
LEU A 745
PHE A 685
 None
 1.16A 4twdI-2henA:
undetectable
4twdJ-2henA:
undetectable		 4twdI-2henA:
19.49
4twdJ-2henA:
19.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 9 VAL A 643
ALA A 659
MET A 710
GLY A 713
LEU A 761
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.52A 4u5jB-2henA:
27.0		 4u5jB-2henA:
42.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 12 ALA A 659
GLU A 678
MET A 682
LEU A 745
HIS A 752
ASP A 772
 ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
None
None
ADP  A 400 ( 4.8A)
 1.12A 4v01A-2henA:
24.5		 4v01A-2henA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 12 ALA A 659
GLU A 678
MET A 682
LEU A 745
HIS A 752
ASP A 772
 ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
None
None
ADP  A 400 ( 4.8A)
 1.08A 4v01B-2henA:
24.2		 4v01B-2henA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 11 ALA A 659
THR A 707
MET A 710
GLY A 713
ASN A 759
LEU A 761
 ADP  A 400 (-3.2A)
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.2A)
MG  A 404 (-4.5A)
ADP  A 400 ( 4.7A)
 0.59A 4wa9A-2henA:
28.4		 4wa9A-2henA:
39.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 VAL A 643
ALA A 659
THR A 707
MET A 710
GLY A 713
ASN A 759
LEU A 761
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.2A)
MG  A 404 (-4.5A)
ADP  A 400 ( 4.7A)
 0.92A 4wa9B-2henA:
31.4		 4wa9B-2henA:
39.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 VAL A 643
ALA A 659
THR A 707
PHE A 709
MET A 710
GLY A 713
LEU A 761
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-4.7A)
None
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 0.72A 4wa9B-2henA:
31.4		 4wa9B-2henA:
39.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		8 / 12 VAL A 643
ALA A 659
LYS A 661
ILE A 705
THR A 707
PHE A 709
GLY A 713
LEU A 761
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 0.74A 4xeyA-2henA:
32.3		 4xeyA-2henA:
30.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		8 / 12 VAL A 643
ALA A 659
LYS A 661
MET A 682
THR A 707
PHE A 709
GLY A 713
LEU A 761
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 1.00A 4xeyA-2henA:
32.3		 4xeyA-2henA:
30.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 VAL A 643
ALA A 659
ILE A 705
THR A 707
PHE A 709
GLY A 713
LEU A 761
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 0.53A 4xeyB-2henA:
26.3		 4xeyB-2henA:
30.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		5 / 8 GLY A 636
VAL A 643
ALA A 659
MET A 710
GLY A 713
 ADP  A 400 ( 3.9A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
ADP  A 400 ( 4.2A)
 0.80A 4zauA-2henA:
32.1		 4zauA-2henA:
33.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		4 / 10 ALA A 659
PHE A 709
GLY A 713
LEU A 761
 ADP  A 400 (-3.2A)
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 0.29A 5ajqB-2henA:
20.0		 5ajqB-2henA:
26.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 12 VAL A 643
ALA A 659
LYS A 661
THR A 707
GLY A 713
LEU A 761
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 0.61A 5h2uA-2henA:
26.4		 5h2uA-2henA:
37.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 VAL A 643
ALA A 659
LYS A 661
ILE A 705
THR A 707
GLY A 713
LEU A 761
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 0.69A 5h2uB-2henA:
26.5		 5h2uB-2henA:
37.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		5 / 12 ALA A 659
LYS A 661
THR A 707
GLY A 713
LEU A 761
 ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 0.59A 5h2uC-2henA:
26.3		 5h2uC-2henA:
37.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		5 / 12 VAL A 643
ALA A 659
ILE A 691
ILE A 705
THR A 707
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
None
ADP  A 400 (-4.7A)
 0.41A 5hesA-2henA:
11.0		 5hesA-2henA:
31.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 12 VAL A 643
ALA A 659
LYS A 661
ILE A 705
THR A 707
GLY A 774
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
None
ADP  A 400 (-4.7A)
None
 0.90A 5hesB-2henA:
27.0		 5hesB-2henA:
31.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		5 / 12 VAL A 643
ALA A 659
LYS A 661
ILE A 705
THR A 707
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
None
ADP  A 400 (-4.7A)
 0.61A 5hieA-2henA:
26.3		 5hieA-2henA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		5 / 12 GLY A 638
VAL A 643
ALA A 659
ILE A 705
THR A 707
 ADP  A 400 ( 4.0A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
ADP  A 400 (-4.7A)
 0.84A 5hieB-2henA:
26.2		 5hieB-2henA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		5 / 12 VAL A 643
ALA A 659
LYS A 661
ILE A 705
THR A 707
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
None
ADP  A 400 (-4.7A)
 0.63A 5hieB-2henA:
26.2		 5hieB-2henA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		5 / 12 GLY A 638
VAL A 643
ALA A 659
ILE A 705
THR A 707
 ADP  A 400 ( 4.0A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
ADP  A 400 (-4.7A)
 0.83A 5hieD-2henA:
26.2		 5hieD-2henA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		5 / 12 VAL A 643
ALA A 659
LYS A 661
ILE A 705
THR A 707
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
None
ADP  A 400 (-4.7A)
 0.61A 5hieD-2henA:
26.2		 5hieD-2henA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		8 / 12 ILE A 635
ALA A 659
GLU A 678
ILE A 691
ILE A 705
THR A 707
GLY A 713
LEU A 761
 ADP  A 400 (-4.9A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 0.59A 5i9xA-2henA:
37.4		 5i9xA-2henA:
67.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		8 / 12 ILE A 635
ALA A 659
GLU A 678
ILE A 691
THR A 707
GLY A 713
LEU A 761
SER A 771
 ADP  A 400 (-4.9A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.74A 5i9xA-2henA:
37.4		 5i9xA-2henA:
67.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		8 / 12 ILE A 635
ALA A 659
GLU A 678
MET A 682
THR A 707
GLY A 713
LEU A 761
SER A 771
 ADP  A 400 (-4.9A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.72A 5i9yA-2henA:
37.5		 5i9yA-2henA:
67.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		8 / 12 ILE A 635
ALA A 659
LYS A 661
GLU A 678
MET A 682
THR A 707
LEU A 761
SER A 771
 ADP  A 400 (-4.9A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.75A 5i9yA-2henA:
37.5		 5i9yA-2henA:
67.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		3 / 3 ILE A 691
ILE A 705
MET A 710
 None
 0.19A 5i9yA-2henA:
37.5		 5i9yA-2henA:
67.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		4 / 5 ILE A 624
ILE A 656
HIS A 647
VAL A 658
 None
 1.01A 5jmnA-2henA:
undetectable		 5jmnA-2henA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 9 ILE A 635
GLY A 636
VAL A 643
ALA A 659
ILE A 691
LEU A 761
 ADP  A 400 (-4.9A)
ADP  A 400 ( 3.9A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
ADP  A 400 ( 4.7A)
 1.30A 5lw1B-2henA:
14.7		 5lw1B-2henA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		6 / 9 ILE A 635
GLY A 636
VAL A 643
ALA A 659
ILE A 691
MET A 710
 ADP  A 400 (-4.9A)
ADP  A 400 ( 3.9A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
None
 0.62A 5lw1B-2henA:
14.7		 5lw1B-2henA:
13.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 GLY A 638
VAL A 643
ALA A 659
LYS A 661
ILE A 705
THR A 707
SER A 771
 ADP  A 400 ( 4.0A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.8A)
 0.79A 5p9iA-2henA:
27.2		 5p9iA-2henA:
37.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		8 / 12 VAL A 643
ALA A 659
LYS A 661
ILE A 705
THR A 707
GLY A 713
LEU A 761
SER A 771
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.52A 5p9iA-2henA:
27.2		 5p9iA-2henA:
37.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		8 / 12 VAL A 643
ALA A 659
MET A 682
ILE A 691
THR A 707
MET A 710
GLY A 713
LEU A 761
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 0.98A 6bsdA-2henA:
30.6		 6bsdA-2henA:
14.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		11 / 12 ILE A 635
VAL A 643
ALA A 659
LYS A 661
GLU A 678
MET A 682
ILE A 705
THR A 707
MET A 710
GLY A 713
LEU A 761
 ADP  A 400 (-4.9A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
ADP  A 400 ( 4.9A)
None
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 0.59A 6fnmA-2henA:
39.9		 6fnmA-2henA:
79.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		10 / 12 ILE A 635
VAL A 643
ALA A 659
LYS A 661
GLU A 678
THR A 707
MET A 710
GLY A 713
LEU A 761
SER A 771
 ADP  A 400 (-4.9A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
ADP  A 400 ( 4.9A)
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.58A 6fnmA-2henA:
39.9		 6fnmA-2henA:
79.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H3D_A_DHIA601_0
(DUF2338
DOMAIN-CONTAINING
PROTEIN)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		4 / 5 TYR A 744
ASN A 749
TYR A 750
PHE A 685
 None
 1.40A 6h3dA-2henA:
undetectable		 6h3dA-2henA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 VAL A 643
ALA A 659
GLU A 678
ILE A 705
THR A 707
PHE A 709
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.8A)
 0.68A 6hd6A-2henA:
31.2		 6hd6A-2henA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 VAL A 643
ALA A 659
GLU A 678
MET A 682
THR A 707
PHE A 709
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.8A)
 0.85A 6hd6A-2henA:
31.2		 6hd6A-2henA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 VAL A 643
ALA A 659
ILE A 705
THR A 707
PHE A 709
LEU A 761
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.76A 6hd6A-2henA:
31.2		 6hd6A-2henA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2hen EPHRIN TYPE-B
RECEPTOR 2
(Mus
musculus) 		7 / 12 VAL A 643
ALA A 659
GLU A 678
MET A 682
THR A 707
PHE A 709
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.8A)
 0.90A 6hd6B-2henA:
31.2		 6hd6B-2henA:
12.36