SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hes'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 2hes YDR267CP
(Saccharomyces
cerevisiae) 		4 / 7 SER X  19
HIS X 158
SER X 203
LEU X 214
 None
 1.16A 1ibgL-2hesX:
undetectable		 1ibgL-2hesX:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_B_KANB501_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 2hes YDR267CP
(Saccharomyces
cerevisiae) 		5 / 9 ASP X  53
ASP X  33
GLY X  30
SER X  77
SER X  83
 None
 1.24A 1m4iB-2hesX:
0.0		 1m4iB-2hesX:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 2hes YDR267CP
(Saccharomyces
cerevisiae) 		5 / 10 ALA X 313
THR X 314
VAL X 300
HIS X 249
ALA X 257
 None
 1.18A 1r55A-2hesX:
undetectable		 1r55A-2hesX:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 2hes YDR267CP
(Saccharomyces
cerevisiae) 		5 / 11 LEU X  27
ALA X 313
VAL X  39
LEU X  48
LEU X  10
 None
 1.05A 1rlbF-2hesX:
undetectable		 1rlbF-2hesX:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 2hes YDR267CP
(Saccharomyces
cerevisiae) 		4 / 8 PHE X 323
ALA X 313
LEU X  27
ASP X 318
 None
 1.06A 2bxkA-2hesX:
undetectable		 2bxkA-2hesX:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 2hes YDR267CP
(Saccharomyces
cerevisiae) 		5 / 12 GLY X 217
SER X 221
GLY X 198
LEU X 245
CYH X 215
 None
CA  X 400 (-2.4A)
None
None
None
 1.46A 3r24A-2hesX:
undetectable		 3r24A-2hesX:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2hes YDR267CP
(Saccharomyces
cerevisiae) 		4 / 4 GLY X  76
GLY X 112
THR X 124
LEU X 122
 None
 0.74A 3si7C-2hesX:
undetectable
3si7D-2hesX:
undetectable		 3si7C-2hesX:
20.30
3si7D-2hesX:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2hes YDR267CP
(Saccharomyces
cerevisiae) 		4 / 5 LEU X 122
GLY X  76
GLY X 112
THR X 124
 None
 0.75A 3si7C-2hesX:
undetectable
3si7D-2hesX:
undetectable		 3si7C-2hesX:
20.30
3si7D-2hesX:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2hes YDR267CP
(Saccharomyces
cerevisiae) 		3 / 3 ASN X 322
TRP X 324
ASP X 318
 None
 1.26A 4a7tA-2hesX:
undetectable
4a7tF-2hesX:
undetectable		 4a7tA-2hesX:
17.42
4a7tF-2hesX:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 2hes YDR267CP
(Saccharomyces
cerevisiae) 		4 / 5 LEU X  27
SER X  40
LEU X  10
LEU X 304
 None
 1.33A 4n09D-2hesX:
undetectable		 4n09D-2hesX:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2hes YDR267CP
(Saccharomyces
cerevisiae) 		5 / 12 ALA X  28
LEU X  27
ALA X 114
ASN X 255
GLY X  30
 None
 0.90A 4r3aB-2hesX:
undetectable		 4r3aB-2hesX:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 2hes YDR267CP
(Saccharomyces
cerevisiae) 		4 / 6 GLY X  76
SER X 126
THR X 124
VAL X  82
 None
 1.08A 5ysiA-2hesX:
undetectable		 5ysiA-2hesX:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 2hes YDR267CP
(Saccharomyces
cerevisiae) 		4 / 6 GLY X 315
SER X  31
THR X  29
VAL X 321
 None
 1.02A 5ysiA-2hesX:
undetectable		 5ysiA-2hesX:
17.80