SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hev'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2hev TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER 4
(Homo
sapiens) 		5 / 9 LEU F 151
VAL F 135
VAL F 165
GLY F 107
LEU F 117
 None
 1.50A 1lwfA-2hevF:
undetectable		 1lwfA-2hevF:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2hev TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER 4
TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER 4
(Homo
sapiens;
Homo
sapiens) 		3 / 3 LYS R  79
ASP F  90
ASP F 147
 None
 0.97A 2br4D-2hevR:
undetectable		 2br4D-2hevR:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 2hev TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER 4
(Homo
sapiens) 		4 / 8 VAL F 165
VAL F 135
VAL F  64
GLY F 168
 None
 0.84A 3hjoB-2hevF:
undetectable		 3hjoB-2hevF:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 2hev TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER 4
(Homo
sapiens) 		4 / 8 ARG R  65
GLY R  70
ASP R 104
PRO R  80
 None
 0.87A 4eyrB-2hevR:
undetectable		 4eyrB-2hevR:
16.44