SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hey'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2hey TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER 4
(Mus
musculus) 		5 / 12 ILE F 168
GLY F  65
SER F  78
LEU F 154
LEU F 106
 None
 1.11A 1rjdA-2heyF:
undetectable		 1rjdA-2heyF:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2hey TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER 4
(Mus
musculus) 		5 / 12 ILE F 168
GLY F  65
SER F  78
LEU F 154
LEU F 106
 None
 1.09A 1rjdB-2heyF:
undetectable		 1rjdB-2heyF:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2hey TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER 4
(Mus
musculus) 		5 / 12 ILE F 168
GLY F  65
SER F  78
LEU F 154
LEU F 106
 None
 1.06A 1rjdC-2heyF:
undetectable		 1rjdC-2heyF:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2hey TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER 4
(Mus
musculus) 		4 / 7 PHE F 110
VAL F 156
VAL F  67
ILE F 168
 None
 0.99A 1t87B-2heyF:
undetectable		 1t87B-2heyF:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 2hey TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER 4
(Mus
musculus) 		4 / 8 PHE F 110
VAL F 156
VAL F  67
ILE F 168
 None
 0.98A 2qbmA-2heyF:
undetectable		 2qbmA-2heyF:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 2hey TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER 4
(Mus
musculus) 		4 / 7 LEU F 154
LEU F 118
PRO F 130
ILE F 129
 None
 0.85A 3s56B-2heyF:
undetectable		 3s56B-2heyF:
19.01