SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hf0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 2hf0 BILE SALT HYDROLASE
(Bifidobacterium
longum) 		5 / 12 LEU A  75
VAL A 115
VAL A 125
LEU A 122
LEU A 127
 None
 1.11A 1mx1E-2hf0A:
undetectable		 1mx1E-2hf0A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hf0 BILE SALT HYDROLASE
(Bifidobacterium
longum) 		5 / 12 VAL A  41
ALA A  44
LEU A 127
SER A 129
TYR A  38
 None
 0.90A 1qzfA-2hf0A:
undetectable		 1qzfA-2hf0A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hf0 BILE SALT HYDROLASE
(Bifidobacterium
longum) 		5 / 12 VAL A  41
ALA A  44
LEU A 127
SER A 129
TYR A  38
 None
 0.90A 1qzfB-2hf0A:
undetectable		 1qzfB-2hf0A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hf0 BILE SALT HYDROLASE
(Bifidobacterium
longum) 		5 / 12 VAL A  41
ALA A  44
LEU A 127
SER A 129
TYR A  38
 None
 0.90A 1qzfC-2hf0A:
undetectable		 1qzfC-2hf0A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hf0 BILE SALT HYDROLASE
(Bifidobacterium
longum) 		5 / 12 VAL A  41
ALA A  44
LEU A 127
SER A 129
TYR A  38
 None
 0.90A 1qzfD-2hf0A:
undetectable		 1qzfD-2hf0A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hf0 BILE SALT HYDROLASE
(Bifidobacterium
longum) 		5 / 12 VAL A  41
ALA A  44
LEU A 127
SER A 129
TYR A  38
 None
 0.88A 1qzfE-2hf0A:
undetectable		 1qzfE-2hf0A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2hf0 BILE SALT HYDROLASE
(Bifidobacterium
longum) 		5 / 12 VAL A  41
ALA A  44
LEU A 127
SER A 129
TYR A  38
 None
 0.98A 2oipA-2hf0A:
undetectable		 2oipA-2hf0A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2hf0 BILE SALT HYDROLASE
(Bifidobacterium
longum) 		5 / 12 VAL A  41
ALA A  44
LEU A 127
SER A 129
TYR A  38
 None
 0.96A 2oipC-2hf0A:
undetectable		 2oipC-2hf0A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2hf0 BILE SALT HYDROLASE
(Bifidobacterium
longum) 		4 / 8 LEU A 183
ARG A 228
VAL A   4
GLY A   3
 None
 0.76A 2po5B-2hf0A:
undetectable		 2po5B-2hf0A:
20.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 2hf0 BILE SALT HYDROLASE
(Bifidobacterium
longum) 		3 / 3 ASN A  81
ASN A 172
ARG A 225
 None
 0.39A 2rlcA-2hf0A:
40.4		 2rlcA-2hf0A:
35.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2hf0 BILE SALT HYDROLASE
(Bifidobacterium
longum) 		5 / 12 ILE A  54
ASN A  71
GLY A  74
ASP A 146
TYR A 286
 None
 1.17A 2zw9A-2hf0A:
undetectable		 2zw9A-2hf0A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZV_A_AZMA263_1
(CARBONIC ANHYDRASE
13)		 2hf0 BILE SALT HYDROLASE
(Bifidobacterium
longum) 		5 / 12 VAL A 153
PHE A 104
VAL A 162
VAL A 115
VAL A 108
 None
 1.11A 3czvA-2hf0A:
undetectable
3czvB-2hf0A:
undetectable		 3czvA-2hf0A:
20.49
3czvB-2hf0A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2hf0 BILE SALT HYDROLASE
(Bifidobacterium
longum) 		5 / 12 VAL A  41
ALA A  44
LEU A 127
SER A 129
TYR A  38
 None
 0.95A 3hj3C-2hf0A:
undetectable		 3hj3C-2hf0A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2hf0 BILE SALT HYDROLASE
(Bifidobacterium
longum) 		5 / 12 VAL A  41
ALA A  44
LEU A 127
SER A 129
TYR A  38
 None
 0.97A 3hj3D-2hf0A:
undetectable		 3hj3D-2hf0A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 2hf0 BILE SALT HYDROLASE
(Bifidobacterium
longum) 		5 / 11 GLY A  74
SER A 114
ASP A 113
ASP A 116
ASN A  12
 None
 0.97A 3v8vB-2hf0A:
undetectable		 3v8vB-2hf0A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hf0 BILE SALT HYDROLASE
(Bifidobacterium
longum) 		5 / 11 VAL A 256
ASP A  20
SER A 222
VAL A 229
THR A 273
 None
 1.38A 4eilA-2hf0A:
undetectable		 4eilA-2hf0A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hf0 BILE SALT HYDROLASE
(Bifidobacterium
longum) 		5 / 11 VAL A 256
ASP A  20
SER A 222
VAL A 229
THR A 273
 None
 1.38A 4eilC-2hf0A:
undetectable		 4eilC-2hf0A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hf0 BILE SALT HYDROLASE
(Bifidobacterium
longum) 		5 / 11 VAL A 256
ASP A  20
SER A 221
VAL A 229
THR A 273
 None
 1.47A 4eilE-2hf0A:
undetectable		 4eilE-2hf0A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hf0 BILE SALT HYDROLASE
(Bifidobacterium
longum) 		5 / 11 VAL A 256
ASP A  20
SER A 222
VAL A 229
THR A 273
 None
 1.36A 4eilE-2hf0A:
undetectable		 4eilE-2hf0A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hf0 BILE SALT HYDROLASE
(Bifidobacterium
longum) 		5 / 11 VAL A 256
ASP A  20
SER A 222
VAL A 229
THR A 273
 None
 1.42A 4kyaA-2hf0A:
undetectable		 4kyaA-2hf0A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2hf0 BILE SALT HYDROLASE
(Bifidobacterium
longum) 		3 / 3 SER A 129
ALA A 100
VAL A  99
 None
 0.57A 4o2bA-2hf0A:
undetectable		 4o2bA-2hf0A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2hf0 BILE SALT HYDROLASE
(Bifidobacterium
longum) 		3 / 3 SER A 129
ALA A 100
VAL A  99
 None
 0.64A 4o2bC-2hf0A:
undetectable		 4o2bC-2hf0A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hf0 BILE SALT HYDROLASE
(Bifidobacterium
longum) 		5 / 12 VAL A  41
ALA A  44
LEU A 127
SER A 129
TYR A  38
 None
 0.94A 4q0dA-2hf0A:
undetectable		 4q0dA-2hf0A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hf0 BILE SALT HYDROLASE
(Bifidobacterium
longum) 		5 / 12 VAL A  41
ALA A  44
LEU A 127
SER A 129
TYR A  38
 None
 0.94A 4q0dB-2hf0A:
undetectable		 4q0dB-2hf0A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hf0 BILE SALT HYDROLASE
(Bifidobacterium
longum) 		5 / 12 VAL A  41
ALA A  44
LEU A 127
SER A 129
TYR A  38
 None
 0.94A 4q0dE-2hf0A:
undetectable		 4q0dE-2hf0A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 2hf0 BILE SALT HYDROLASE
(Bifidobacterium
longum) 		5 / 12 GLY A   3
LEU A 170
SER A 150
VAL A 152
PHE A 226
 None
 1.08A 4wnwB-2hf0A:
undetectable		 4wnwB-2hf0A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 2hf0 BILE SALT HYDROLASE
(Bifidobacterium
longum) 		5 / 12 TYR A  14
GLN A 239
ALA A 243
ALA A 244
TYR A 287
 None
 1.49A 5cxvA-2hf0A:
undetectable		 5cxvA-2hf0A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2hf0 BILE SALT HYDROLASE
(Bifidobacterium
longum) 		5 / 12 ALA A 230
ILE A  29
PHE A 275
GLY A  57
THR A 171
 None
 1.32A 5jlcA-2hf0A:
undetectable		 5jlcA-2hf0A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2hf0 BILE SALT HYDROLASE
(Bifidobacterium
longum) 		5 / 9 LEU A 170
SER A 150
GLY A 145
PHE A  15
PHE A 226
 None
 1.35A 6ebpA-2hf0A:
undetectable		 6ebpA-2hf0A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 2hf0 BILE SALT HYDROLASE
(Bifidobacterium
longum) 		4 / 5 TYR A  36
GLY A  35
HIS A  37
ASP A  39
 None
 0.81A 6gh9A-2hf0A:
undetectable		 6gh9A-2hf0A:
12.11