SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hf7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RMT_A_ADNA1501_1
(CLASS B ACID
PHOSPHATASE)		 2hf7 CLASS B ACID
PHOSPHATASE
(Escherichia
coli) 		10 / 10 ASP A  46
PHE A  56
TYR A  70
LEU A  71
TRP A  77
THR A 112
GLY A 113
ARG A 114
THR A 192
TYR A 193
 AF3  A 800 ( 3.7A)
None
None
None
None
AF3  A 800 (-3.6A)
AF3  A 800 (-3.5A)
None
None
None
 0.31A 1rmtA-2hf7A:
33.9		 1rmtA-2hf7A:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 2hf7 CLASS B ACID
PHOSPHATASE
(Escherichia
coli) 		7 / 7 PHE A  56
GLU A  68
TYR A  70
LEU A  71
THR A 192
TYR A 193
LYS A 194
 None
 0.41A 1rmtB-2hf7A:
34.1		 1rmtB-2hf7A:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 2hf7 CLASS B ACID
PHOSPHATASE
(Escherichia
coli) 		8 / 8 ASP A  46
PHE A  56
TYR A  70
LEU A  71
TRP A  77
GLY A 113
ASP A 145
TYR A 193
 AF3  A 800 ( 3.7A)
None
None
None
None
AF3  A 800 (-3.5A)
None
None
 0.26A 1rmtC-2hf7A:
36.8		 1rmtC-2hf7A:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 2hf7 CLASS B ACID
PHOSPHATASE
(Escherichia
coli) 		5 / 8 TYR A  70
LEU A  71
TRP A  77
GLY A 144
ASP A 145
 None
 1.17A 1rmtC-2hf7A:
36.8		 1rmtC-2hf7A:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 2hf7 CLASS B ACID
PHOSPHATASE
(Escherichia
coli) 		8 / 8 ASP A  46
PHE A  56
TYR A  70
LEU A  71
TRP A  77
ASP A 145
THR A 192
TYR A 193
 AF3  A 800 ( 3.7A)
None
None
None
None
None
None
None
 0.44A 1rmtD-2hf7A:
36.7		 1rmtD-2hf7A:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2B82_A_ADNA1001_1
(CLASS B ACID
PHOSPHATASE)		 2hf7 CLASS B ACID
PHOSPHATASE
(Escherichia
coli) 		7 / 10 LYS A  60
GLU A  68
TYR A  70
LEU A  71
TRP A  77
GLY A 144
ASP A 145
 None
 1.04A 2b82A-2hf7A:
36.6		 2b82A-2hf7A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2B82_A_ADNA1001_1
(CLASS B ACID
PHOSPHATASE)		 2hf7 CLASS B ACID
PHOSPHATASE
(Escherichia
coli) 		10 / 10 PHE A  56
LYS A  60
GLU A  68
TYR A  70
LEU A  71
TRP A  77
GLY A 113
ASP A 145
THR A 192
TYR A 193
 None
None
None
None
None
None
AF3  A 800 (-3.5A)
None
None
None
 0.66A 2b82A-2hf7A:
36.6		 2b82A-2hf7A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2B82_B_ADNB1002_1
(CLASS B ACID
PHOSPHATASE)		 2hf7 CLASS B ACID
PHOSPHATASE
(Escherichia
coli) 		6 / 9 LYS A  60
GLU A  68
TYR A  70
LEU A  71
TRP A  77
GLY A 144
 None
 1.06A 2b82B-2hf7A:
37.1		 2b82B-2hf7A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2B82_B_ADNB1002_1
(CLASS B ACID
PHOSPHATASE)		 2hf7 CLASS B ACID
PHOSPHATASE
(Escherichia
coli) 		9 / 9 PHE A  56
LYS A  60
GLU A  68
TYR A  70
LEU A  71
TRP A  77
GLY A 113
THR A 192
TYR A 193
 None
None
None
None
None
None
AF3  A 800 (-3.5A)
None
None
 0.56A 2b82B-2hf7A:
37.1		 2b82B-2hf7A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2B8J_A_SPMA653_1
(CLASS B ACID
PHOSPHATASE)		 2hf7 CLASS B ACID
PHOSPHATASE
(Escherichia
coli) 		9 / 9 ASP A  46
PHE A  56
TRP A  57
LYS A  60
TYR A  70
GLY A 113
ASP A 145
THR A 192
TYR A 193
 AF3  A 800 ( 3.7A)
None
None
None
None
AF3  A 800 (-3.5A)
None
None
None
 0.46A 2b8jA-2hf7A:
37.0		 2b8jA-2hf7A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2B8J_B_ADNB331_1
(CLASS B ACID
PHOSPHATASE)		 2hf7 CLASS B ACID
PHOSPHATASE
(Escherichia
coli) 		10 / 10 ASP A  46
SER A  53
PHE A  56
TYR A  70
LEU A  71
TRP A  77
GLY A 113
ARG A 114
THR A 192
TYR A 193
 AF3  A 800 ( 3.7A)
None
None
None
None
None
AF3  A 800 (-3.5A)
None
None
None
 0.23A 2b8jB-2hf7A:
34.4		 2b8jB-2hf7A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2hf7 CLASS B ACID
PHOSPHATASE
(Escherichia
coli) 		4 / 8 GLY A 166
THR A 173
ALA A 174
ALA A 175
 None
 0.56A 2ej3C-2hf7A:
1.2		 2ej3C-2hf7A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2hf7 CLASS B ACID
PHOSPHATASE
(Escherichia
coli) 		5 / 12 LEU A 156
ASP A 171
GLY A  42
LEU A  97
ILE A  29
 None
MG  A 700 ( 4.5A)
None
None
None
 0.91A 3ku1C-2hf7A:
2.2		 3ku1C-2hf7A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 2hf7 CLASS B ACID
PHOSPHATASE
(Escherichia
coli) 		3 / 3 ASP A  44
TRP A  77
SER A  52
 MG  A 700 ( 2.5A)
None
None
 0.91A 4lrhB-2hf7A:
undetectable		 4lrhB-2hf7A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 2hf7 CLASS B ACID
PHOSPHATASE
(Escherichia
coli) 		3 / 3 ASP A  44
TRP A  77
SER A  52
 MG  A 700 ( 2.5A)
None
None
 0.90A 4lrhF-2hf7A:
undetectable		 4lrhF-2hf7A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_C_CLQC1079_0
(SAPOSIN-B)		 2hf7 CLASS B ACID
PHOSPHATASE
(Escherichia
coli) 		4 / 5 ARG A 181
MET A 100
GLU A  30
LEU A  33
 None
 1.39A 4v2oA-2hf7A:
0.0
4v2oC-2hf7A:
0.0		 4v2oA-2hf7A:
15.69
4v2oC-2hf7A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2hf7 CLASS B ACID
PHOSPHATASE
(Escherichia
coli) 		3 / 3 VAL A  93
LEU A  97
VAL A  26
 None
 0.57A 4wq4A-2hf7A:
undetectable		 4wq4A-2hf7A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 2hf7 CLASS B ACID
PHOSPHATASE
(Escherichia
coli) 		3 / 3 ASN A 150
ASP A  44
GLY A 166
 None
MG  A 700 ( 2.5A)
None
 0.61A 5fctB-2hf7A:
undetectable		 5fctB-2hf7A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_F_FK5F201_1
(FK506-BINDING
PROTEIN 1)		 2hf7 CLASS B ACID
PHOSPHATASE
(Escherichia
coli) 		5 / 12 ASP A 171
VAL A 140
ILE A 141
ILE A 161
ILE A 185
 MG  A 700 ( 4.5A)
None
None
None
None
 1.11A 5hw8B-2hf7A:
undetectable
5hw8F-2hf7A:
undetectable
5hw8G-2hf7A:
undetectable		 5hw8B-2hf7A:
23.50
5hw8F-2hf7A:
23.50
5hw8G-2hf7A:
23.50