SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hf8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A  91
ALA A  72
ILE A  63
LEU A 117
LEU A  97
 None
 1.13A 1eiiA-2hf8A:
undetectable		 1eiiA-2hf8A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  57
HIS A  82
ILE A  50
PHE A  38
ILE A 213
 None
 1.44A 1ot7B-2hf8A:
undetectable		 1ot7B-2hf8A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB
(Methanocaldococc
us
jannaschii) 		4 / 5 VAL A 165
ASN A 167
VAL A 209
ILE A 139
 None
GSP  A 300 (-3.2A)
None
None
 1.07A 1z2bC-2hf8A:
undetectable		 1z2bC-2hf8A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB
(Methanocaldococc
us
jannaschii) 		5 / 8 GLU A  51
LEU A 200
LEU A 198
VAL A 165
ILE A 142
 None
GSP  A 300 (-4.2A)
None
None
None
 1.45A 2uxpA-2hf8A:
undetectable		 2uxpA-2hf8A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB
(Methanocaldococc
us
jannaschii) 		4 / 5 PHE A  36
PHE A  38
LEU A  49
PHE A 206
 None
 1.34A 2y69P-2hf8A:
undetectable
2y69W-2hf8A:
undetectable		 2y69P-2hf8A:
19.93
2y69W-2hf8A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  28
ASN A  29
LEU A  27
LEU A 109
LEU A 116
 None
 1.11A 3d90B-2hf8A:
undetectable		 3d90B-2hf8A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB
(Methanocaldococc
us
jannaschii) 		3 / 3 GLY A  43
GLY A  45
THR A  47
 GSP  A 300 (-3.1A)
GSP  A 300 (-3.2A)
MG  A 301 ( 3.1A)
 0.43A 3si7B-2hf8A:
3.1		 3si7B-2hf8A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB
(Methanocaldococc
us
jannaschii) 		5 / 9 LEU A  27
LYS A  26
VAL A  33
GLY A  32
LEU A 106
 None
 1.48A 4b3oA-2hf8A:
undetectable		 4b3oA-2hf8A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB
(Methanocaldococc
us
jannaschii) 		4 / 7 LEU A  28
THR A 135
ILE A 119
GLY A 103
 None
 0.76A 4eq4A-2hf8A:
1.7		 4eq4A-2hf8A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB
(Methanocaldococc
us
jannaschii) 		4 / 8 LEU A  28
THR A 135
ILE A 119
GLY A 103
 None
 0.69A 4eq4B-2hf8A:
1.7		 4eq4B-2hf8A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB
(Methanocaldococc
us
jannaschii) 		4 / 7 LEU A  28
THR A 135
ILE A 119
GLY A 103
 None
 0.72A 4eqlA-2hf8A:
undetectable		 4eqlA-2hf8A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB
(Methanocaldococc
us
jannaschii) 		4 / 7 LEU A  28
THR A 135
ILE A 119
GLY A 103
 None
 0.74A 4eqlB-2hf8A:
1.6		 4eqlB-2hf8A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB
(Methanocaldococc
us
jannaschii) 		4 / 7 ALA A 161
ASP A 162
VAL A 165
ILE A 119
 None
 0.62A 4eyrA-2hf8A:
undetectable		 4eyrA-2hf8A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB
(Methanocaldococc
us
jannaschii) 		4 / 7 LEU A  28
THR A 135
ILE A 119
GLY A 103
 None
 0.72A 4l39B-2hf8A:
1.9		 4l39B-2hf8A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB
(Methanocaldococc
us
jannaschii) 		4 / 6 LEU A 210
LEU A 163
PHE A 206
LEU A  49
 None
 0.94A 5gs4A-2hf8A:
undetectable		 5gs4A-2hf8A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB
(Methanocaldococc
us
jannaschii) 		4 / 5 LEU A 210
LEU A 163
PHE A 206
LEU A  49
 None
 0.92A 5gtrA-2hf8A:
undetectable		 5gtrA-2hf8A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB
(Methanocaldococc
us
jannaschii) 		4 / 5 LEU A  48
GLY A  45
ASP A 170
ILE A 169
 GSP  A 300 (-4.3A)
GSP  A 300 (-3.2A)
GSP  A 300 (-2.9A)
None
 0.89A 5ik1A-2hf8A:
undetectable		 5ik1A-2hf8A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB
(Methanocaldococc
us
jannaschii) 		4 / 7 ASN A 110
ALA A  35
VAL A 102
LEU A 106
 None
 0.76A 6dwnB-2hf8A:
undetectable		 6dwnB-2hf8A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		 2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB
(Methanocaldococc
us
jannaschii) 		5 / 10 GLY A  32
LEU A  28
HIS A 136
PHE A 118
VAL A 220
 None
 1.29A 6gnfC-2hf8A:
2.4		 6gnfC-2hf8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  66
ASN A 121
ASP A  98
LEU A 101
ASN A  24
 None
 1.19A 6r2eA-2hf8A:
undetectable		 6r2eA-2hf8A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A  66
ASN A 121
ASP A  98
LEU A 101
ASN A  24
 None
 1.18A 6r2eB-2hf8A:
undetectable		 6r2eB-2hf8A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A  66
ASN A 121
ASP A  98
LEU A 101
ASN A  24
 None
 1.20A 6r2eC-2hf8A:
undetectable		 6r2eC-2hf8A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A  66
ASN A 121
ASP A  98
LEU A 101
ASN A  24
 None
 1.23A 6r2eD-2hf8A:
undetectable		 6r2eD-2hf8A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A  66
ASN A 121
ASP A  98
LEU A 101
ASN A  24
 None
 1.21A 6r2eF-2hf8A:
undetectable		 6r2eF-2hf8A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A  66
ASN A 121
ASP A  98
LEU A 101
ASN A  24
 None
 1.26A 6r2eG-2hf8A:
undetectable		 6r2eG-2hf8A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  66
ASN A 121
ASP A  98
LEU A 101
ASN A  24
 None
 1.20A 6r2eH-2hf8A:
undetectable		 6r2eH-2hf8A:
22.29